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Absorption of dietary alkylresorcinols in ileal-cannulated pigs and rats

Published online by Cambridge University Press:  09 March 2007

Alastair B. Ross ,
Martin J. Shepherd ,
Knud Erik Bach Knudsen ,
L. Vibe Glitsø ,
Elizabeth Bowey ,
John Phillips ,
Ian Rowland ,
Zhao-Xia Guo ,
D. J. R. Massy  and
Per Åman
...Show all authors
Alastair B. Ross*
Affiliation:
Department of Food Science, Swedish University of Agricultural Sciences (SLU), Box 7051, SE-750 07 Uppsala, Sweden
Martin J. Shepherd
Affiliation:
CSL Food Science Laboratory, Norwich Research Park, Norwich NR4 7UQ and Institute of Food Research, Norwich NR4 7UA, UK
Knud Erik Bach Knudsen
Affiliation:
Department of Animal Nutrition and Physiology, Danish Institute of Agricultural Sciences, PO Box 50, Research Centre Foulum, 8830 Tjele, Denmark
L. Vibe Glitsø
Affiliation:
Department of Animal Nutrition and Physiology, Danish Institute of Agricultural Sciences, PO Box 50, Research Centre Foulum, 8830 Tjele, Denmark
Elizabeth Bowey
Affiliation:
BIBRA International, Carshalton, Surrey, UK
John Phillips
Affiliation:
BIBRA International, Carshalton, Surrey, UK
Ian Rowland
Affiliation:
BIBRA International, Carshalton, Surrey, UK
Zhao-Xia Guo
Affiliation:
School of Chemical Sciences, University of East Anglia, Norwich NR4 7TJ, UK
D. J. R. Massy
Affiliation:
Morello Close, Norwich NR4 7NF, UK
Per Åman
Affiliation:
Department of Food Science, Swedish University of Agricultural Sciences (SLU), Box 7051, SE-750 07 Uppsala, Sweden
Afaf Kamal-Eldin
Affiliation:
Department of Food Science, Swedish University of Agricultural Sciences (SLU), Box 7051, SE-750 07 Uppsala, Sweden
*
*Corresponding author: Mr Alastair Ross, fax +46 18 67 2995, email [email protected]
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Abstract

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Alkylresorcinols (AR) are amphiphilic 1,3-dihydroxy-5-alkyl phenolic lipids. AR in food are only found in the outer layers of wheat and rye grains, and in whole grains are present at concentrations of 500–1000 μg/g. In wheat and rye, there are five main homologues, differing in the length of the odd-numbered alkyl chain (from seventeen to twenty-five C atoms long). Because AR may be bioactive, and might serve as biomarkers for these cereals, their absorption was investigated in model experiments with pigs and rats. Pigs with a cannula in the terminal ileum were fed four diets containing rye fractions with different levels of AR and the ileal effluents were analysed. The ileal recovery of AR was found to vary between 21 and 40 %, with no major difference between different chain-length homologues. The absorption of AR by rats was investigated by feeding 14C-labelled heneicosylresorcinol (C21:0). Of the total activity, about 34% was recovered in the urine, showing that the labelled AR was absorbed and metabolised by rats. AR were mostly cleared from rats by 60h. It is concluded that AR are absorbed in the small intestine of single-stomached animals and excreted in metabolised form in the urine, and might contribute to the nutritional qualities of wholegrain wheat and rye diets.

Keywords

AlkylresorcinolsIleal absorptionWholegrain rye
Type
Research Article
Information
British Journal of Nutrition , Volume 90 , Issue 4 , October 2003 , pp. 787 - 794
Copyright
Copyright © The Nutrition Society 2003

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