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Reevaluation of the protein requirement in Chinese elderly adults without sarcopenia with the indicator amino acid oxidation technique

Published online by Cambridge University Press:  11 December 2023

Wenxuan Wu Open the ORCID record for Wenxuan Wu [Opens in a new window] ,
Yanhong Zhang ,
Hui Ma ,
Jiaxi Lu ,
Fengge Chen ,
Haisong Zhou ,
Shuhui Nie ,
Yunqi Yang ,
Rui Wang  and
Weixiao Yue
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Wenxuan Wu
Affiliation:
Key Laboratory of Trace Element Nutrition, National Health Commission, National Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention, Beijing, People’s Republic of China
Yanhong Zhang
Affiliation:
Zhengding County Center for Disease Control and Prevention, Zhengding, Hebei, People’s Republic of China
Hui Ma
Affiliation:
Shijiazhuang Center for Disease Control and Prevention, Shijiazhuang, Hebei, People’s Republic of China
Jiaxi Lu
Affiliation:
Key Laboratory of Trace Element Nutrition, National Health Commission, National Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention, Beijing, People’s Republic of China
Fengge Chen
Affiliation:
Shijiazhuang Center for Disease Control and Prevention, Shijiazhuang, Hebei, People’s Republic of China
Haisong Zhou
Affiliation:
Zhengding County Center for Disease Control and Prevention, Zhengding, Hebei, People’s Republic of China
Shuhui Nie
Affiliation:
Key Laboratory of Trace Element Nutrition, National Health Commission, National Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention, Beijing, People’s Republic of China
Yunqi Yang
Affiliation:
Key Laboratory of Trace Element Nutrition, National Health Commission, National Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention, Beijing, People’s Republic of China
Rui Wang
Affiliation:
Key Laboratory of Trace Element Nutrition, National Health Commission, National Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention, Beijing, People’s Republic of China
Weixiao Yue
Affiliation:
Key Laboratory of Trace Element Nutrition, National Health Commission, National Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention, Beijing, People’s Republic of China
Min Li*
Affiliation:
Key Laboratory of Trace Element Nutrition, National Health Commission, National Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention, Beijing, People’s Republic of China
Lichen Yang*
Affiliation:
Key Laboratory of Trace Element Nutrition, National Health Commission, National Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention, Beijing, People’s Republic of China
*
*Corresponding authors: Min Li, email [email protected]; Lichen Yang, email [email protected]
*Corresponding authors: Min Li, email [email protected]; Lichen Yang, email [email protected]
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Abstract

It is now generally believed that elderly may have slightly higher dietary protein requirements than those of the young-middle-aged adults. We have previously conducted related studies by the indicator amino acid oxidation (IAAO) technique, but more research data are needed to revise the protein requirements of the elderly. The main objective was to reevaluate the dietary protein requirements of healthy Chinese adults (65–80 years) without sarcopenia by using the IAAO technique. Nine healthy adult men and seven healthy adult women participated in the study, with protein intakes ranging from 0·1 to 1·8 g/(kg·d). Diets that delivered energy at a 1·5 resting energy expenditure were isocaloric. The amounts of phenylalanine and tyrosine needed to remain constant for each protein dosage. By applying a nonlinear mixed-effects model analysis on the F13CO2 data, which revealed a breakpoint in F13CO2 in response to graded protein intakes, the mean protein requirement was calculated. The mean estimated average requirement (EAR) for healthy elderly Chinese adults without sarcopenia was determined to be 0·94 g/(kg·d). The protein recommended nutrient intake (RNI) determined using various derivation approaches ranged from 1·13 to 1·36 g/(kg·d). The EAR for Chinese adults without sarcopenia aged 65–80 years in this study is 6·8 % higher than the current recommended EAR (0·88 g/(kg·d)). The RNI derived using various derivation approaches are all greater than the current RNI (0·98 g/(kg·d)). This trial was registered with the Chinese clinical trial registry as ChiCTR2200061382.

Keywords

Protein requirementOlder adultsIndicator amino acid oxidationStable isotopePhenylalanine flux
Type
Research Article
Information
British Journal of Nutrition , Volume 131 , Issue 8 , 28 April 2024 , pp. 1377 - 1383
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Copyright
© The Author(s), 2023. Published by Cambridge University Press on behalf of The Nutrition Society

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Footnotes

†

These authors contributed equally to this work.

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