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Changing Brains: The Emergence of the Field of Adult Neurogenesis

Published online by Cambridge University Press:  22 December 2009

Beatrix P. Rubin*
Affiliation:
Collegium Helveticum, Semper-Sternwarte, Schmelzbergstr. 25, CH 8092 Zürich, Switzerland E-mail: [email protected]
*
*The author is also affiliated with Programm für Wissenschaftsforschung, Universität Basel.
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Abstract

The increasing appreciation of structural plasticity, namely the capacity of the nervous system to alter not only its function but also its constitution in response to changing conditions, indicates a profound transformation in the scientific comprehension of the human brain. The research on adult neurogenesis, i.e. on the de novo formation of neurons in the mature brain, has been chosen as a circumscribed field to study the controversies that accompany the transition from the concept of a stable to that of a structurally plastic mammalian brain. Building on the concepts of thought style and thought collective developed by Ludwik Fleck, this article investigates the ways in which neurogenesis in the adult brain has changed from being negated to being accepted and highly valued, and consequently has become the focus of a novel research field. This analysis covers a period from the second half of the twentieth century up to the present. The development of research on adult neurogenesis has been shaped by two opposing views: the understanding of a particularly immutable and thus specifically human brain on the one hand, and a plastic brain which remains malleable during the entire adult life, on the other hand. This plastic human brain has created new space for the articulation of the ‘therapeutic promise’, since it lends itself much more readily to therapeutic intervention than a stable brain: the article argues this to be decisive in promoting the transformation of thought style within the neurosciences.

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Articles
Copyright
Copyright © London School of Economics and Political Science 2009

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References

Altman, J. (1962). Are New Neurons Formed in the Brains of Adult Mammals? Science, 11271128.CrossRefGoogle ScholarPubMed
Altman, J. (1963). Autoradiographic investigation of cell proliferation in the brains of rats and cats. Anat Rec, 145, 573591.CrossRefGoogle Scholar
Altman, J. (1969). Autoradiographic and histological studies of postnatal neurogenesis, IV. Cell proliferation and migration in the anterior forebrain, with special reference to persisting neurogenesis in the olfactory bulb. Journal of Comparative Neurology, 137, 433457.CrossRefGoogle ScholarPubMed
Altman, J., & Das, G.D. (1965a). Autoradiographic and histological evidence of postnatal hippocampal neurogenesis in rats. Journal of Comparative Neurology, 124: 319335.CrossRefGoogle ScholarPubMed
Altman, J., & Das, G.D. (1965b). Post-natal origin of microneurones in the rat brain. Nature, 207, 953956.CrossRefGoogle ScholarPubMed
Altman, J., & Das, G.D. (1967). Postnatal neurogenesis in the guinea-pig. Nature, 214, 10981101.CrossRefGoogle ScholarPubMed
Barinaga, M. (1998). No-new-neurons dogma loses ground. Science, 279, 20412042.CrossRefGoogle ScholarPubMed
Bayer, S.A., Yackel, J.W., & Puri, P.S. (1982). Neurons in the rat dentate gyrus granular layer substantially increase during juvenile and adult life. Science, 216, 890892.CrossRefGoogle ScholarPubMed
Bayer, S.A. (1985). Neuron production in the hippocampus and olfactory bulb of the adult rat brain: addition or replacement?. Annals of the New York Academy of Sciences, 457, 163172.CrossRefGoogle ScholarPubMed
Berlucchi, G., & Buchtel, H.A. (2009). Neuronal plasticity: Historical roots and evolution of meaning. Experimental Brain Research, 192, 307319.CrossRefGoogle ScholarPubMed
Blakeslee, S. (2000). A decade of discovery yields a shock about the brain. New York Times, 4 January.Google Scholar
Bradbury, J. (2005). Molecular insights into human brain evolution. PLoS Biology, 3(3), e50.CrossRefGoogle ScholarPubMed
Cajal, R.Y. (1928). Degeneration and regeneration of the nervous system. New York: Haffner Publishing Co.Google Scholar
Cameron, H.A., Woolley, B.S., McEwen, B.S., & Gould, E. (1993). Differentiation of newly born neurons and glia in the dentate gyrus of the adult rat. Neuroscience, 56, 337344.CrossRefGoogle ScholarPubMed
Doidge, N. (2007). The brain that changes itself: Stories of personal triumph from the frontiers of brain science. New York: Penguin Books.Google Scholar
Eriksson, P.S., Perfilieva, E., Björk-Eriksson, T., Alborn, A.M., Nordborg, C., Peterson, D.A., et al. (1998). Neurogenesis in the adult human hippocampus. Nature Medicine, 4, 13131317.CrossRefGoogle ScholarPubMed
Fleck, L. (1979). Genesis and development of a scientific fact. Chicago: U Chicago Press.Google Scholar
Gage, F.H., Kempermann, G., & Song, H. (Eds) (2008). Adult neurogenesis. New York: Cold Spring Harbor Laboratory Press.Google Scholar
Gazzaniga, M.S. (2007). Are human brains unique? Edge: The Third Culture, 4 October, URL (accessed October 2009): http://www.edge.org/3rd_culture/gazzaniga08/gazzaniga08_index.htmlGoogle Scholar
Goldman, S.A., & Nottebohm, F. (1983). Neuronal production, migration, and differentiation in a vocal control nucleus of the adult female canary brain. Proceedings of the National Academy of Science of the USA, 80, 23902394.CrossRefGoogle Scholar
Gould, E. (2007). How widespread is adultneurogenesis in mammals? Nature Reviews Neuroscience, 8, 481488.CrossRefGoogle Scholar
Gould, E., Cameron, H.A., Daniels, D.C., Woolley, C.S., & McEwen, B.S. (1992). Adrenal hormones suppress cell division in the adult rat dentate gyrus. Journal of Neuroscience, 12, 36423650.CrossRefGoogle ScholarPubMed
Gould, E., McEwen, B.S., Tanapat, P., Galea, L.A., & Fuchs, E. (1997) Neurogenesis in the dentate gyrus of the adult tree shrew is regulated by psychosocial stress and NMDA receptor activation. Journal of Neuroscience, 17, 24922498.CrossRefGoogle ScholarPubMed
Gould, E., Tanapat, P., McEwen, B.S., Flügge, G., & Fuchs, E. (1998). Proliferation of granule cell precursors in the dentate gyrus of adult monkeys is diminished by stress. Proceedings of the National Academy of Science of the USA, 95, 31683171.CrossRefGoogle ScholarPubMed
Gould, E., Reeves, A.J., Graziano, M.S., & Gross, C.G. (1999). Neurogenesis in the neocortex of adult primates. Science, 286, 548552.CrossRefGoogle ScholarPubMed
Gross, C.G. (1998). Brain, vision, memory: Tales in the history of neuroscience. Cambridge, MA: MIT Press.CrossRefGoogle Scholar
Gross, C.G. (2000). Neurogenesis in the adult brain: Death of a dogma. Nature Reviews Neuroscience, 1, 6773.CrossRefGoogle ScholarPubMed
Grote, H.E., & Hannan, A.J. (2007). Regulators of adult neurogenesis in the healthy and diseased brain. Clinical and Experimental Pharmacology and Physiology, 34, 533545.CrossRefGoogle ScholarPubMed
Hughes, W.L., Bond, V.P., Brecher, G., Cronkite, E.P., Painter, R.B., Quastler, H. et al. (1958). Cellular proliferation in the mouse as revealed by autoradiography with tritiated thymidine. Proceedings of the National Academy of Science of the USA, 44, 476483.CrossRefGoogle ScholarPubMed
Ihrie, R.A., & Alvarez-Buylla, A. (2008). Cells in the astroglial lineage are neural stem cells. Cell and Tissue Research, 331,179191.CrossRefGoogle ScholarPubMed
Kandel, E.R., Schwartz, J.H., & Jessell, T.M. (2000). Principles of Neural Science, 4th edn. New York: McGraw-Hill.Google Scholar
Kaplan, M.S. (1981). Neurogenesis in the 3-month-old rat visual cortex. Journal of Comparative Neurology, 195, 323338.CrossRefGoogle ScholarPubMed
Kaplan, M.S. (2001). Environment complexity stimulates visual cortex neurogenesis: Death of a dogma and a research career. Trends in Neurosciences, 24, 617620.CrossRefGoogle Scholar
Kaplan, M.S., & Hinds, J.W. (1977). Neurogenesis in the adult rat: Electron microscopic analysis of light radioautographs. Science, 197, 10921094.CrossRefGoogle ScholarPubMed
Kaplan, M.S., & Hinds, J.W. (1980). Gliogenesis of astrocytes and oligodendrocytes in the neocortical grey and white matter of the adult rat: Electron microscopic analysis of light radioautographs. Journal of Comparative Neurology, 193, 711727.CrossRefGoogle ScholarPubMed
Kaplan, M.S., McNelly, N.A., & Hinds, J.W. (1985). Population dynamics of adult-formed granule neurons of the rat olfactory bulb. Journal of Comparative Neurology, 239, 117125.CrossRefGoogle ScholarPubMed
Kempermann, G. (2006). Adult neurogenesis: Stem cells and neuronal development in the adult brain. Oxford: Oxford UP.Google Scholar
Kolata, G. (1984). New neurons form in adulthood. Science, 224, 13251326.CrossRefGoogle ScholarPubMed
Kornack, D.R., & Rakic, P. (2001). Cell proliferation without neurogenesis in adult primate neocortex. Science, 294, 21272130.CrossRefGoogle ScholarPubMed
Lehrer, J. (2006). The reinvention of the self: A mind-altering idea reveals how life affects the brain. Seedmagazine.com, URL (accessed August 2009): http://seedmagazine.com/news/2006/02/the_reinvention_of_the_self.php?page=all&p=yGoogle Scholar
Maasen, S. (2007). Selves in turmoil: The neurocognitive and societal challenges of the self. In J.S. Jordan, & D.M. McBride (Eds), The concepts of consciousness: Integrating an emerging science, Special Issue of Journal of Consciousness, 14, 252–270.Google Scholar
Maasen, S., & Weingart, P. (2000). Metaphors and the dynamics of knowledge. London: Routledge.Google Scholar
Martin, E. (1995). Flexible bodies: Tracking immunity in American culture from the days of polio to the age of AIDS. Boston, MA: Beacon Press.Google Scholar
Martin, E. (2007). Bipolar expeditions: Mania and depression in American culture. Princeton, NJ: Princeton UP.CrossRefGoogle Scholar
Ming, G., & Song, H. (2005). Adult neurogenesis in the mammalian central nervous system. Annual Review of Neuroscience, 28, 223250.CrossRefGoogle ScholarPubMed
Nottebohm, F. (1981). A brain for all seasons: Cyclical anatomical changes in song control nuclei of the canary brain. Science, 214, 13681370.CrossRefGoogle Scholar
Nottebohm, F., (Ed.) (1984). Hope for a new neurology. New York: Annals of the New York Academy of Sciences.Google Scholar
Nottebohm, F. (2004). The road we travelled: Discovery, choreography, and significance of brain replaceable neurons. Annals of the New York Academy of Sciences, 1016, 628658.CrossRefGoogle ScholarPubMed
Nowakowski, R.S. (2006). Stable neuron numbers from cradle to grave. Proceedings of the National Academy of Sciences of the USA, 103, 1221912220.CrossRefGoogle ScholarPubMed
Rakic, P. (1985a). DNA synthesis and cell division in the adult primate brain. In Nottebohm, F. (Ed.), Hope for a new neurology, 193–211. New York: Annals of the New York Academy of Sciences.Google Scholar
Rakic, P. (1985b). Limits of neurogenesis in primates. Science, 227, 10541056.CrossRefGoogle ScholarPubMed
Reynolds, B.A., & Weiss, S. (1992). Generation of neurons and astrocytes from isolated cells of the adult mammalian central nervous system. Science, 255, 17071710.CrossRefGoogle ScholarPubMed
Richards, L.J., Kilpatrick, T.J., & Bartlett, P.F. (1992). De novo generation of neuronal cells from the adult mouse brain. Proceedings of the National Academy of Sciences of the USA, 89, 85918595.CrossRefGoogle ScholarPubMed
Rose, N. (2007). The politics of life itself: Biomedicine, power, and subjectivity in the twenty-first century. Princeton, NJ: Princeton UP.CrossRefGoogle Scholar
Rubin, B.P. (2008). Therapeutic promise in the discourse of human embryonic stem cell research. Science as Culture, 17, 1327.CrossRefGoogle Scholar
Specter, M. (2001). Rethinking the brain: How the songs of canaries upset a fundamental principle of science. New Yorker, 23 July, 4253.Google Scholar
Society for Neuroscience (2007). Adult neurogenesis. Brain Briefings, June, URL (accessed August 2009): http://www.sfn.org/index.aspx?pagename=brainBriefings_adult_neurogenesisGoogle Scholar
Wade, N. (1999). Brain may grow new cells daily. New York Times, 15 October.Google Scholar
Will, B., Dalrymple-Alford, J., Wolff, M., & Cassel, J. C. (2008a). The concept of brain plasticity—Paillard’s systemic analysis and emphasis on structure and function (followed by the translation of a seminal paper by Paillard on plasticity). Behavioral Brain Research, 192, 27.CrossRefGoogle ScholarPubMed
Will, B., Dalrymple-Alford, J., Wolff, M., & Cassel, J. C. (2008b). Reflections on the use of the concept of plasticity in neurobiology. Translation and adaptation by B. Will, J. Dalrymple-Alford, M. Wolff, & J. C. Cassel from J. Paillard (1976). Journal of Psychology, 1: 33–47, in Behavioral Brain Research, 192, 711.CrossRefGoogle ScholarPubMed