Hostname: page-component-cd9895bd7-7cvxr Total loading time: 0 Render date: 2024-12-25T08:00:40.541Z Has data issue: false hasContentIssue false

Benzodiazepines and Behavioural Treatment of Phobic Anxiety

Published online by Cambridge University Press:  16 June 2009

Gudrun Sartory
Affiliation:
Department of Psychology, Institute of Psychiatry, De Crespigny Park

Extract

The use of benzodiazepines during behavioural treatment is frequently encouraged. However, this review of clinical studies failed to find any beneficial effect of the drugs on therapy outcome. An examination of drug effects on different response variables revealed conflicting results concerning behaviour, i.e. approach. Whilst the anxiolytic nature of the drugs is well established in results on autonomic measures in the absence of the phobic object, they had no effect during its presence. Verbal report data again favour administration of benzodiazepines but studies on cognitive effects of long-term use are still to come. It is recommended that the use of this group of drugs as an adjunct to behaviour therapy should be discouraged.

Type
Research Article
Copyright
Copyright © British Association for Behavioural and Cognitive Psychotherapies 1983

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Bernadt, M. W., Silverstone, T. and Singleton, W. (1980). Behavioural and subjective effects of beta-adrenergic blockade in phobic subjects. British Journal of Psychiatry 137, 452457.Google Scholar
Besser, G. M. (1967). Time course of action of diazepam. Nature 214, 428.Google Scholar
Bond, A. J. and Lader, M. H. (1972). Residual effects of hypnotics. Psychopharmacologia 25, 117132.Google Scholar
Bond, A. J. and Lader, M. H. (1973). The residual effects of flurazepam. Psychopharmacologia 32, 223235.Google Scholar
Bond, A. J. and Lader, M. H. (1975). Residual effects of flunitrazepam. British Journal of Clinical Pharmacology 2, 143150.Google Scholar
Bond, A. J. and Lader, M. H. (1981). Comparative effects of diazepam and buspirone on subjective feelings, psychological tests and the E.E.G. International Pharmacopsychiatry 16, 212220.CrossRefGoogle Scholar
Goodman, L. S. and Gilman, A. (Eds) (1980). The Pharmacological Basis of Therapeutics, 6th Edit.New York: Macmillan.Google Scholar
Gorman, J. E., Dyak, J. D. and Reid, L. D. (1979). Methods of deconditioning persistent avoidance: diazepam as an adjunct to response prevention. Bulletin of the Psychonomic Society 14, 4648.Google Scholar
Gray, A. J., Davis, N., Feldon, J., Owen, S. and Boardia, M. (1981a). Stress tolerance: possible neural mechanisms. In Foundations of Psychosomatics Christie, M. J. and Mellett, P. G. (Eds), London: Wiley.Google Scholar
Grey, S. J., Rachman, S. and Sartory, G. (1981b). Return of fear: the role of inhibition. Behaviour Research and Therapy 19, 135143.Google Scholar
Hafner, J. and Marks, I. (1976). Exposure in vivo of agoraphobics: contributions of diazepam, group exposure and anxiety evocation. Psychological Medicine 6, 7188.Google Scholar
Hafner, J. and Milton, F. (1977). The influence of propranolol on the exposure in vivo of agoraphobics. Psychological Medicine 7, 419425.Google Scholar
Johnston, D. and Gath, D. (1973). Arousal levels and attribution effects in diazepam assisted flooding. British Journal of Psychiatry 123, 463466.Google Scholar
Johnstone, E. C., Bourne, R. C., Crow, T. J., Frith, C. D., Gamble, S., Lofthourse, R., Owen, F., Owens, D. G. C., Robinson, J. and Stevens, M. (1981). The relationship between clinical response, psychophysiological variables and plasma levels of amytryptyline and diazepam in neurotic outpatients. Psychopharmacology 72, 233240.Google Scholar
Kendall, P. C., Williams, L., Pechacek, T. F., Graham, L. E., Shisslak, C. and Herzoff, N. (1979). Cognitive-behavioural and patient education interventions in cardiac catheterization procedures: the Palo Alto medical psychology project. Journal of Consulting and Clinical Psychology 47, 4958.Google Scholar
Lacey, J. T. (1967). Somatic response patterning and stress: some revisions of activation theory. In Psychological Stress: Issues in Research, Appley, M. H. and Trumbull, R., (Eds.), New York: Appleton-Century-Crofts, pp. 1437.Google Scholar
Lader, M. H. and Mathews, A. M. (1968). A physiological model of phobic anxiety and desensitization. Behaviour Research and Therapy 6, 411421.Google Scholar
Lader, M. H. and Wing, L. (1966). Physiological Measures of Sedative drugs, and Morbid anxiety. London: Oxford University Press.Google Scholar
Marks, I. M., Vistranathan, R., Lipsedge, M. S. and Garner, R. (1972). Enanced relief of phobics by flooding during waning diazepam effect. British Journal of Psychiatry 121, 493505.Google Scholar
Marks, I. M., Stern, R. S., Mawson, D., Cobb, J. and McDonald, R. (1980). Clomipramine and exposure for obsessive-compulsive rituals: I. British Journal of Psychiatry 136, 125.Google Scholar
Mathews, A. (1977). Recent developments in the treatment of agoraphobia. Behaviour Analysis and Modification 2, 6475.Google Scholar
Mathews, A., Gelder, M. G. and Johnston, D. (1981). Agoraphobia. London: Tavistock Publications.Google Scholar
Nisbett, R. E. and Schachter, S. (1966). Cognitive manipulation of pain. Journal of Experimental and Social Psychology 2, 227236.Google Scholar
Nisbett, R. E. and Wilson, T. D. (1977). Telling more than we can know: verbal reports on mental processes. Psychological Review 84, 231259.Google Scholar
Oishi, H., Iwahara, S., Yang, K. and Yogi, A. (1972). Effects of chlordiazepoxide on passive avoidance responses in rats. Psychopharmacologia 23, 373385.Google Scholar
Overton, D. A. (1966). State-dependent learning produced by depressant and atropine-like drugs. Psychopharmacologia 10, 631.Google Scholar
Patel, J. B., Ciofalo, V. B., Iorio, L. C. (1979). Benzodiazepine blockade of passive-avoidance task in mice: a state-dependent phenomenon. Psychopharmacologia 61, 2528.Google Scholar
Rachman, S. J. (1978). Fear and Courage. San Francisco: Freeman & Company.Google Scholar
Rachman, S. and Hodgson, R. (1974). Synchrony and desynchrony in fear and avoidance. Behaviour Research and Therapy 12, 311318.Google Scholar
Rachman, S., Cobb, J., Grey, S., McDonald, B., Mawson, D., Sartory, G. and Stern, R. (1979). The behavioural treatment of obsessional-compulsive disorders with and without clomipramine. Behaviour Research and Therapy 17, 467478.Google Scholar
Rimm, E., Brinddell, D., Zimmerman, M. and Caddy, G. (1981). The effects of alcohol and the expectancy of alcohol on snake fear. Addictive Behaviours 6, 4751.Google Scholar
Sherman, A. R. (1967). Therapy of maladaptive fear-motivated behaviour in the rat by the systematic gradual withdrawal of a fear-reducing drug. Behaviour Research and Therapy 5, 121129.Google Scholar
Strian, F. and Klicpera, C. (1977). Anxiety, arousal and autonomic habituation. Archiv für Psychiatrie und Nervenkrankheiten 224, 341350.CrossRefGoogle ScholarPubMed
Taub, J., Taylor, P., Smith, M., Kelley, K., Becker, B. and Reid, L. (1977). Methods of deconditioning persistent avoidance: drugs as adjuncts to persistent response prevention. Physiological Psychology 5, 6772.CrossRefGoogle Scholar
Whitehead, W. E., Robinson, A., Blackwell, B. and Stulz, R. M. (1978a). Flooding treatment of phobics: does chronic diazepam increase effectiveness? Journal of Behaviour Therapy and Experimental Psychiatry 9, 219225.Google Scholar
Whitehead, W. E., Blackwell, B. and Robinson, A. (1978b). Effects of diazepam on phobic avoidance behaviour and phobic anxiety. Biological Psychiatry 13, 5964.Google Scholar
Submit a response

Comments

No Comments have been published for this article.