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What exactly is central to the role of central neuroplasticity in persistent pain?

Published online by Cambridge University Press:  01 September 1997

Terence J. Coderre  and
Joel Katz
Terence J. Coderre
Affiliation:
Pain Mechanisms Laboratory, Clinical Research Institute of Montreal Centre de recherche en sciences neurologiques et departement demédecine, Université de Montréal Department of Psychology, McGill University, Montreal, Quebec H2W 1R7, [email protected] www.ircm.umontreal.ca/
Joel Katz
Affiliation:
Department of Psychology and Acute Pain Research Unit, The Toronto Hospital Departments of Behavioral Science and Anaesthesia, University of Toronto, Toronto, Ontario M5S 2C4 [email protected] www.utoronto.ca/
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Abstract

The commentaries on our target article have raised important issues about central neuroplasticity and its role in persistent pain states. Some suggest that central neuroplasticity plays nothing more than a minor role in persistent pain, while others argue that persistent pain depends critically on peripheral inputs for its maintenance. Some stress that persistent pain relies to a large extent on changes in the brain and on centrifugal inputs from brain to spinal cord, whereas others argue that it depends on alterations in inhibitory as well as excitatory systems. We attempt to address each of the commentators' points, while defending our position that central neuroplasticity is critical to pathological persistent pain states.

Type
Author's Response
Information
Behavioral and Brain Sciences , Volume 20 , Issue 3 , September 1997 , pp. 483 - 486
Copyright
© 1997 Cambridge University Press

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