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Visualizing genetic similarity at the symptom level: The example of learning disabilities

Published online by Cambridge University Press:  29 June 2010

Oliver S. P. Davis  and
Robert Plomin
Oliver S. P. Davis
Affiliation:
MRC Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King's College London, London SE5 8AF, United Kingdom. [email protected]://www.iop.kcl.ac.uk/staff/profile/[email protected]://www.iop.kcl.ac.uk/staff/profile/?go=10628
Robert Plomin
Affiliation:
MRC Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King's College London, London SE5 8AF, United Kingdom. [email protected]://www.iop.kcl.ac.uk/staff/profile/[email protected]://www.iop.kcl.ac.uk/staff/profile/?go=10628
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Abstract

Psychological traits and disorders are often interrelated through shared genetic influences. A combination of maximum-likelihood structural equation modelling and multidimensional scaling enables us to open a window onto the genetic architecture at the symptom level, rather than at the level of latent genetic factors. We illustrate this approach using a study of cognitive abilities involving over 5,000 pairs of twins.

Type
Open Peer Commentary
Information
Behavioral and Brain Sciences , Volume 33 , Issue 2-3 , June 2010 , pp. 155 - 157
Copyright
Copyright © Cambridge University Press 2010

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