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Underconstrained thalamic activation + underconstrained top-down modulation of cortical input processing = underconstrained perceptions

Published online by Cambridge University Press:  15 June 2005

Martin Sarter  and
Gary G. Berntson
Martin Sarter*
Affiliation:
Department of Psychology, University of Michigan, Ann Arbor, MI48109
Gary G. Berntson*
Affiliation:
Department of Psychology, Ohio State University, Columbus, OH43210
*
[email protected]
[email protected]
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Abstract:

Behrendt & Young's (B&Y's) theory offers a potentially important perspective on the neurobiology of schizophrenia, but it remains incomplete. In addition to bottom-up contributions, such as those associated with disturbances in sensory constraints on cognitive processes, a comprehensive model requires the integration of the consequences of abnormal top-down modulation of input processing for the evolution of “underconstrained” perceptions. Dysfunctional cholinergic modulation of input functions represents a necessary mechanism for the generation of false perceptions.

Type
Open Peer Commentary
Information
Behavioral and Brain Sciences , Volume 27 , Issue 6 , December 2004 , pp. 803 - 804
Copyright
Copyright © Cambridge University Press 2004

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