Hostname: page-component-cd9895bd7-7cvxr Total loading time: 0 Render date: 2024-12-27T08:50:37.548Z Has data issue: false hasContentIssue false
  • English
  • Français

Taste quality coding in vertebrate receptor molecules and cells

Published online by Cambridge University Press:  08 April 2008

Linda M. Kennedy  and
Kristina M. Gonzalez
Linda M. Kennedy
Affiliation:
Neuroscience Laboratory, Lasry Center for the Biosciences, Clark University, Worcester, MA 01610. [email protected]@clarku.edu
Kristina M. Gonzalez
Affiliation:
Neuroscience Laboratory, Lasry Center for the Biosciences, Clark University, Worcester, MA 01610. [email protected]@clarku.edu
Get access Rights & Permissions [Opens in a new window]

Abstract

Recent work on receptor molecules and cells used prototypical sweet, salty, sour, bitter, and umami stimuli. Labeled-line coding was supported, but it remains possible that the molecules and cells could respond to other tastants. Studies with other tastants are needed. The sensory message might contain two codes – one for attraction or aversion, the other, across-fiber patterning of stimulus quality.

Type
Open Peer Commentary
Information
Behavioral and Brain Sciences , Volume 31 , Issue 1 , February 2008 , pp. 82 - 83
Copyright
Copyright © Cambridge University Press 2008

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Chandrashekar, J., Hoon, M. A., Ryba, J. P. & Zucker, C. S. (2006) The receptors and cells for mammalian taste. Nature 444:288–94.CrossRefGoogle ScholarPubMed
DeFazio, R. A., Dvoryanichikov, G., Maruyama, Y., Kim, J. W., Pereira, E., Roper, S. D. & Chaudhari, N. (2006) Separate populations of receptor cells and presynaptic cells in mouse taste buds. Journal of Neuroscience 26:3971–80.CrossRefGoogle ScholarPubMed
Dethier, V. G. (1974) The specificity of the labellar chemoreceptors of the blowfly and the response to natural foods. Journal of Insect Physiology 20:1859–69.Google Scholar
Dethier, V. G. (1976) The hungry fly: A physiological study of the behaviour associated with feeding. Harvard University Press.Google Scholar
Galindo-Cuspinera, V., Winning, M., Bufe, B., Meyerhof, W. & Breslin, P. A. (2006) TAS1R receptor-based explanation of sweet ‘water-taste’. Nature 441:354–57.Google Scholar
Herness, S. (2000) Coding in taste receptor cells: The early years of intracellular recordings. Physiology and Behavior 69:17–27.Google Scholar
Jiang, P., Cui, M., Snyder, L. A., Benard, L. M., Osman, R., Max, M. & Margolskee, R. F. (2005) Identification of the cyclamate interaction site within the transmembrane domain of the human sweet taste receptor subunit T1R3. Journal of Biological Chemistry 280:34296–305.CrossRefGoogle ScholarPubMed
Jiang, P., Ji, Q., Liu, Z., Snyder, L. A., Benard, L. M., Margolskee, R. F. & Max, M. (2004) The cysteine-rich region of T1R3 determines responses to intensely sweet proteins. Journal of Biochemistry 270:45068–75.Google Scholar
Li, W., Staszewski, L., Xu, H., Durick, K., Zoller, M. & Adler, E. (2002) Human receptors for sweet and umami taste. Proceedings of the National Academy of Sciences 99:4692–96.Google Scholar
Morini, G., Bassoli, A. & Temussi, P. A. (2005) From small sweeteners to sweet proteins: Anatomy of the binding sites of the human T1R2/T1R3 receptor. Journal of Medicinal Chemistry 48:5520–29.Google Scholar
Sugita, M. (2006) Taste perception and coding in the periphery. Cellular and Molecular Life Sciences 63:2000–15.CrossRefGoogle ScholarPubMed
Tomchik, S. M., Berg, S., Kim, J. W., Chaudhari, N. & Roper, S. D. (2007) Breadth of tuning and taste coding in mammalian taste buds. Journal of Neuroscience 27:10840–48.CrossRefGoogle ScholarPubMed
Xu, H., Staszewski, L., Tang, H., Adler, E., Zoller, M. & Li, X. (2004) Different functional roles of T1R subunits in the heteromeric taste receptors. Proceedings of the National Academy of Sciences 101:14258–63.CrossRefGoogle ScholarPubMed
Zhang, Y., Hoon, M. A., Chandrashekar, J., Mueller, K. L., Cook, B., Wu, D., Zuker, C. S. & Ryba, J. P. (2003) Coding of sweet, bitter, and umami tastes: Different receptor cells sharing similar signaling pathways. Cell 112:293–301.Google Scholar
Zhao, G. Q., Zhang, Y. F., Hoon, M. A., Chandrashekar, J., Erlenbach, I., Ryba, N. J. P. & Zuker, C. S. (2003) The receptors for mammalian sweet and umami taste. Cell 115:255–66.CrossRefGoogle ScholarPubMed