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Sleep and synaptic homeostasis
Published online by Cambridge University Press: 19 July 2005
Abstract
We propose that sleep is linked to synaptic homeostasis. Specifically, we propose that: (1) Wakefulness is associated with synaptic potentiation in cortical circuits; (2) synaptic potentiation is tied to the homeostatic regulation of slow wave activity; (3) slow wave activity is associated with synaptic downscaling; and (4) synaptic downscaling is tied to several beneficial effects of sleep, including performance enhancement.
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- Open Peer Commentary
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- Copyright © Cambridge University Press 2005
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