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Role of capsaicin-sensitive afferent nerves in initiation and maintenance of pathological pain

Published online by Cambridge University Press:  01 September 1997

Gábor Jancsó ,
Mária Dux  and
Péter Sántha
Gábor Jancsó
Affiliation:
Department of Physiology, Albert Szent-Györgyi Medical University, Dóm tér 10, H-6720 Szeged, [email protected]
Mária Dux
Affiliation:
Department of Physiology, Albert Szent-Györgyi Medical University, Dóm tér 10, H-6720 Szeged, [email protected]
Péter Sántha
Affiliation:
Department of Physiology, Albert Szent-Györgyi Medical University, Dóm tér 10, H-6720 Szeged, [email protected]
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Abstract

This commentary provides experimental data in support of the critical role of capsaicin-sensitive primary afferent fibers in the initiation and maintenance of pathological pain. The demonstration of capsaicin-induced, centrally-evoked cutaneous hyperalgesia, and of neuroplastic changes elicited by the degeneration of C-fiber primary afferent terminals following peripheral nerve damage, indicates a significant contribution of capsaicin-sensitive sensory ganglion neurons in the development of pathological pain conditions. [coderre & katz]

Type
Open Peer Commentary
Information
Behavioral and Brain Sciences , Volume 20 , Issue 3 , September 1997 , pp. 454 - 455
Copyright
© 1997 Cambridge University Press

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