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The NGF superfamily of neurotrophins: Potential treatment for Alzheimer's and Parkinson's disease

Published online by Cambridge University Press:  04 February 2010

Elliott J. Mufson  and
Teresa Sobreviela
Elliott J. Mufson
Affiliation:
Departments of Neurological Sciences and Rush Alzheimer's Disease Center, Rush Presbyterian-St. Luke's Medical Center, Chicago, IL 60612
Teresa Sobreviela
Affiliation:
Departments of Neurological Sciences and Rush Alzheimer's Disease Center, Rush Presbyterian-St. Luke's Medical Center, Chicago, IL 60612
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Abstract

Stein & Glasier suggest embryonic neural tissue grafts as a potential treatment strategy for Alzheimer's and Parkinson's disease. As an alternative, we suggest that the family of nerve growth factor-related neurotrophins and their trk (tyrosine kinase) receptors underlie cholinergic basal forebrain (CBF) and dopaminergic substantia nigra neuron degeneration in these diseases, respectively. Therefore, treatment approaches for these disorders could utilize neurotrophins.

Type
Open Peer Commentary
Information
Behavioral and Brain Sciences , Volume 18 , Issue 1: An International Journal of Current Research and Theory with Open Peer Commentary , March 1995 , pp. 63 - 65
Copyright
Copyright © Cambridge University Press 1995

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