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Neurotropic enteroviruses co-opt “fair-weather-friend” commensal gut microbiota to drive host infection and central nervous system disturbances

Published online by Cambridge University Press:  15 July 2019

Kevin B. Clark
Kevin B. Clark*
Affiliation:
Research and Development Service, Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, CA 90073; Felidae Conservation Fund, Mill Valley, CA 94941; Campus Champions, Extreme Science and Engineering Discovery Environment (XSEDE), National Center for Supercomputing Applications, University of Illinois at Urbana-Champaign, Urbana, IL 61801; Expert Network, Penn Center for Innovation, University of Pennsylvania, Philadelphia, PA 19104 ; Virus Focus Group, NASA Astrobiology Institute, NASA Ames Research Center, Moffett Field, CA 94035. [email protected]/pub/kevin-clark/58/67/19a
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Abstract

Some neurotropic enteroviruses hijack Trojan horse/raft commensal gut bacteria to render devastating biomimicking cryptic attacks on human/animal hosts. Such virus-microbe interactions manipulate hosts’ gut-brain axes with accompanying infection-cycle-optimizing central nervous system (CNS) disturbances, including severe neurodevelopmental, neuromotor, and neuropsychiatric conditions. Co-opted bacteria thus indirectly influence host health, development, behavior, and mind as possible “fair-weather-friend” symbionts, switching from commensal to context-dependent pathogen-like strategies benefiting gut-bacteria fitness.

Type
Open Peer Commentary
Information
Behavioral and Brain Sciences , Volume 42 , 2019 , e68
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Copyright
Copyright © Cambridge University Press 2019 

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References

Bordon, Y. (2015) Microbiota: A viral understudy for commensal bacteria. Nature Reviews Immunology 15(1):4.Google Scholar
Clark, K. B. (2013a) Biotic activity of Ca2+-modulating nontraditional antimicrobial and -viral agents. Frontiers in Microbiology 4:381.Google Scholar
Clark, K. B. (2013b) Preface. Current Topics in Medicinal Chemistry 13(18):2281–82.Google Scholar
Clark, K. B. (2018) Possible origins of consciousness in simple control over “involuntary” neuroimmunological action. Consciousness and Cognition 61:76–78.Google Scholar
Clark, K. B. & Eisenstein, E. M. (2013) Targeting host store-operated Ca2+ release to attenuate viral infections. Current Topics in Medicinal Chemistry 13(16):1916–32.Google Scholar
Clark, K. B., Eisenstein, E. M. & Krahl, S. E. (2013) Calcium antagonists: A ready prescription for treating infectious diseases? Current Topics in Medicinal Chemistry 13(18):2291–305.Google Scholar
David, R. (2011) Viral infection. The gut microbiota: friend or foe? Nature Reviews Microbiology 9(12):831.Google Scholar
Erickson, A. K., Jesudhasan, P. R., Mayer, M. J., Narbad, A., Winter, S. E. & Pfeiffer, J. K. (2018) Bacteria facilitate enteric virus co-infection of mammalian cells and promote genetic recombination. Cell Host & Microbe 23(1):77–88.Google Scholar
Karst, S. M. (2016) The influence of commensal bacteria on infection with enteric viruses. Nature Reviews Microbiology 14(4):197–204.Google Scholar
Kuss, S. K., Best, G. T., Etheredge, C. A., Pruijssers, A. J., Frierson, J. M., Hooper, L.V., Dermody, T. S. & Pfeiffer, J. K. (2011) Intestinal microbiota promote enteric virus replication and systemic pathogenesis. Science 334(6053):249–52.Google Scholar
Liu, R. T. (2017) The microbiome as a novel paradigm in studying stress and mental health. American Psychologist 72(7):655–67. Available at: https://doi.org/10.1037/amp0000058.Google Scholar
Mayer, E. A., Knight, R., Mazmanian, S. K., Cryan, J. F. & Tillisch, K. (2014) Gut microbes and the brain: Paradigm shift in neuroscience. Journal of Neuroscience 34(46):15490–96. Available at: https://doi.org/10.1523/JNEUROSCI.3299-14.2014.Google Scholar
Ray, K. (2015) Gut microbiota: A ‘friendly’ gut virus? Nature Reviews Gastroenterology & Hepatology 12(1):6.Google Scholar
Robinson, C. M. & Pfeiffer, J. K. (2014) Viruses and the microbiota. Annual Review of Virology 1:55–69.Google Scholar
Sampson, T. R. & Mazmanian, S. K. (2015) Control of brain development, function, and behavior by the microbiome. Cell Host & Microbe 17:565–76. Available at: https://doi.org/10.1016/j.chom.2015.04.011.Google Scholar
Stilling, R. M., Dinan, T. G. & Cryan, J. F. (2016) The brain's Geppetto – microbes as puppeteers of neural function and behaviour? Journal of Neurovirology 22:14–21. Available at: https://doi.org/10.1007/s13365-015-0355-x.Google Scholar
Wilks, J. & Golovkina, T. (2012) Influence of microbiota on viral infections. PLoS Pathogens 8(5):e1002681.Google Scholar