Hostname: page-component-78c5997874-94fs2 Total loading time: 0 Render date: 2024-11-15T21:16:41.895Z Has data issue: false hasContentIssue false
  • English
  • Français

The neural basis of chronic pain, its plasticity and modulation

Published online by Cambridge University Press:  01 September 1997

Misha-Miroslav Backonja
Misha-Miroslav Backonja
Affiliation:
Department of Neurology, University of Wisconsin-Madison Medical School, Madison, WI 53792-5132 [email protected]
Get access Rights & Permissions [Opens in a new window]

Abstract

Dysfunction or injury of pain-transmitting primary afferents' central pathways can result in pain. The organism as a whole responds to such injury and consequently many symptoms of neuropathic pain develop. The nervous system responds to painful events and injury with neuroplasticity. Both peripheral sensitization and central sensitization take place and are mediated by a number of biochemical factors, including genes and receptors. Correction of altered receptors activity is the logical way to intervene therapeutically. [berkley; blumberg et al.; coderre & katz; dickenson; mcmahon; wiesenfeld-hallinet al.]

Type
Open Peer Commentary
Information
Behavioral and Brain Sciences , Volume 20 , Issue 3 , September 1997 , pp. 435 - 437
Copyright
© 1997 Cambridge University Press

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)