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Na-Ca + K exchanger and Ca2+ homeostasis in retinal rod outer segments: Inactivation of the Ca2+ efflux mode and possible involvement of intracellular Ca2+ stores in Ca2+ homeostasis

Published online by Cambridge University Press:  04 February 2010

Paul P. M. Schnetkamp
Paul P. M. Schnetkamp*
Affiliation:
Department of Medical Biochemistry, University of Calgary, Calgary, Alberta, T2N 4N1, Canada. [email protected]
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Abstract

Inactivation of the Ca2+ extrusion mode of the retinal rod Na- Ca + K exchanger is suggested to be the mechanism that prevents lowering of cytosolic free Ca2+ to < 1 nM when rod cells are saturated for a prolonged time under bright light conditions. Under these conditions, Ca2+ fluxes across disk membranes can contribute significantly to Ca2+ homeostasis in rods.

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Information
Behavioral and Brain Sciences , Volume 18 , Special Issue 3: An International Journal of Current Research and Theory with Open Peer Commentary , September 1995 , pp. 488
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Copyright © Cambridge University Press 1995

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