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Glutamate accumulation in the photoreceptor-presumed final common path of photoreceptor cell death

Published online by Cambridge University Press:  04 February 2010

Makoto Tamai
Makoto Tamai*
Affiliation:
Department of Ophthalmology, Tohoku University School of Medicine, 1-1 Seiryomachi, Aoba-ku Sendai, 980-77, Japan
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Abstract

Genetic abnormalities of three factors related to the photoreceptor mechanism have been reported in both animal models and humans. Apoptotic mechanism has also been suggested as a final common pathway of photoreceptor cell death. Our findings of increased level of glutamate in photoreceptor cells in rds mice suggest that amino acid might mediate between these two pathological mechanisms.

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Information
Behavioral and Brain Sciences , Volume 18 , Special Issue 3: An International Journal of Current Research and Theory with Open Peer Commentary , September 1995 , pp. 490
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Copyright © Cambridge University Press 1995

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