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Finland's Galapagos: Founder effect, drift, and isolation in the inheritance of susceptibility alleles
Published online by Cambridge University Press: 09 November 2006
Abstract:
The target article excludes ancestral neutrality as a cause for the inheritance of schizophrenia, with an argument relating to selection against a single allele in the Finnish population. However, drift would predominate over selection within subisolates of the Finnish population. Comparisons of subisolates with heterogeneous populations may provide clues to the endophenotypic structure of complex polygenetic heritable mental disorders.
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- Copyright © Cambridge University Press 2006
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