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Behavioral effects of neural grafts: Action still in search of a mechanism

Published online by Cambridge University Press:  04 February 2010

Michael L. Woodruff
Michael L. Woodruff
Affiliation:
Department of Anatomy, J. H. Quillen College of Medicine, East Tennessee State University, Johnson City, TN37614-0582. [email protected]
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Abstract

This commentary reviews data supporting circuitry reconstruction, replacement neurotransmitters, and trophic action as mechanisms whereby transplants promote recovery of function. Issue is taken with the thesis of Sinden et al. that adequate data exist to indicate that reconstruction of hippocampal circuitry damaged by hypoxia with CA1 transplants is a confirmed mechanism whereby these transplants produce recovery. Sinden et al.'s and Stein & Glasier's proposal that there is definitive evidence showing that all transplants produce trophic effects is also questioned.

Type
Open Peer Commentary
Information
Behavioral and Brain Sciences , Volume 18 , Issue 1: An International Journal of Current Research and Theory with Open Peer Commentary , March 1995 , pp. 75 - 76
Copyright
Copyright © Cambridge University Press 1995

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