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What are the mechanisms of photoreceptor adaptation?

Published online by Cambridge University Press:  04 February 2010

M. Deric Bownds
Affiliation:
Laboratory of Molecular Biology, University of Wisconsin, Madison, WI 53706. Electronic mail: [email protected]
Vadim Y. Arshavsky
Affiliation:
Harvard Medical School and The Massachusetts Eye and Ear Infirmary, Boston, MA 02114. Electronic mall: [email protected]

Abstract

This article evaluates each of the reactions known to be involved in visual transduction as a potential site for the regulation of light adaptation. Extensive evidence suggests that calcium acts as a feedback messenger at several different points and recent work suggests a role for cGMP in regulating the primary excitatory pathway. A conclusion is that adaptation is likely to be regulated by multiple and redundant mechanisms. The goal of future experimentation will be to determine the relative importance of each of these.

Type
Research Article
Copyright
Copyright © Cambridge University Press 1995

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Footnotes

1

Arshavsky's present address is Howe Laboratories, Harvard Medical School and the Massachusetts Eye and Ear Infirmary, 243 Charles St., Boston, MA 02114.