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The status of LTP as a mechanism of memory formation in the mammalian brain

Published online by Cambridge University Press:  10 October 2000

Tracey J. Shors  and
Louis D. Matzel
Tracey J. Shors
Affiliation:
Department of Psychology and Center for Neuroscience, Rutgers University, New Brunswick, NJ 07728 [email protected]
Louis D. Matzel
Affiliation:
Department of Psychology, Program in Biopsychology and Behavioral Neuroscience, Rutgers University, New Brunswick, NJ 08903 [email protected]
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Abstract

Long-term potentiation (LTP) is a long-lasting increase in synaptic efficacy that many consider the best candidate currently available for a neural mechanism of memory formation and/or storage in the mammalian brain. In our target article, LTP: What's learning got to do with it?, we concluded that there was insufficient data to warrant such a conclusion. In their commentaries, Jeffery and Zhadin raise a number of important issues that we did not raise, both for and against the hypothesis. Although we agree with a number of these issues, we maintain that there remains insufficient evidence that LTP is a memory mechanism.

Type
Author&s Response
Information
Behavioral and Brain Sciences , Volume 23 , Issue 2 , April 2000 , pp. 288 - 290
Copyright
© 2000 Cambridge University Press

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