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High mental disorder rates are based on invalid measures: Questions about the claimed ubiquity of mutation-induced dysfunction

Published online by Cambridge University Press:  09 November 2006

Jerome C. Wakefield
Jerome C. Wakefield*
Affiliation:
School of Social Work, New York University, New York, NY10003http://www.nyu.edu/socialwork/fac-prof-jwakefield.htm
*
[email protected]
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Abstract:

Three reservations about Keller & Miller's (K&M's) argument are explored: Serious validity problems afflict epidemiological criteria discriminating disorders from non-disorders, so high rates may be misleading. Normal variation need not be mild disorder, contrary to a possible interpretation of K&M's article. And, rather than mutation-selection balance, true disorders may result from unselected combinations of normal variants over many loci.

Type
Open Peer Commentary
Information
Behavioral and Brain Sciences , Volume 29 , Issue 4 , August 2006 , pp. 424 - 426
Copyright
Copyright © Cambridge University Press 2006

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