Hostname: page-component-cd9895bd7-dk4vv Total loading time: 0 Render date: 2024-12-20T08:25:53.703Z Has data issue: false hasContentIssue false
  • English
  • Français

Does central nervous system plasticity contribute to hyperalgesia?

Published online by Cambridge University Press:  01 September 1997

Corey L. Cleland  and
G. F. Gebhart
Corey L. Cleland
Affiliation:
Departments of Physiology and Biophysics, and Pharmacology, The University of Iowa, Iowa City, IA 52242 [email protected]
G. F. Gebhart
Affiliation:
Departments of Physiology and Biophysics, and Pharmacology, The University of Iowa, Iowa City, IA 52242 [email protected]
Get access Rights & Permissions [Opens in a new window]

Abstract

Hyperalgesia can arise from peripheral sensitization, on-going peripheral activation, and central plasticity. In the target article, coderre & katz argue that all three mechanisms contribute to hyperalgesia. In contrast, we believe that existing experimental evidence suggests that central plasticity plays only an insignificant role in most experimental models and clinical presentations of hyperalgesia induced by tissue injury or chemical activation of sensory receptors.

Type
Open Peer Commentary
Information
Behavioral and Brain Sciences , Volume 20 , Issue 3 , September 1997 , pp. 444 - 445
Copyright
© 1997 Cambridge University Press

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)