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A branching non-linear autoregressive model for the transmission of the fragile X dynamic repeat mutation

Published online by Cambridge University Press:  01 July 1998

R. M. HUGGINS ,
D. Z. LOESCH  and
S. L. SHERMAN
R. M. HUGGINS
Affiliation:
Department of Statistical Science La Trobe University, Bundoora, 3083, Australia
D. Z. LOESCH
Affiliation:
School of Psychology, La Trobe University, Bundoora, 3083, Australia
S. L. SHERMAN
Affiliation:
Department of Genetics and Molecular Medicine, Emory University School of Medicine, Atlanta, GA 30022, U.S.A.
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Abstract

A non-linear time series version of a model for the transmission of fragile X previously described in Ashley & Sherman (1995) is developed. The model retains the biological features of the Ashley/Sherman model but is easier to generalize and in particular allows the inclusion of covariates such as haplotype to model different paths and random effects to model family effects. The model is fitted to data from Murray et al. (1997) and its properties are illustrated in a simulation study.

Type
Research Article
Information
Annals of Human Genetics , Volume 62 , Issue 4 , July 1998 , pp. 337 - 347
Copyright
© University College London 1998

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