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Polymorphism of the human ABO-Secretor locus (FUT2) in four populations in Asia: indication of distinct Asian subpopulations

Published online by Cambridge University Press:  09 January 2002

H. PANG ,
Y. KODA ,
M. SOEJIMA ,
N. FUJITANI ,
T. OGAKI ,
A. SAITO ,
T. KAWASAKI  and
H. KIMURA
H. PANG
Affiliation:
Division of Human Genetics, Department of Forensic Medicine, Kurume University School of Medicine, Kurume 830-0011, Japan
Y. KODA
Affiliation:
Division of Human Genetics, Department of Forensic Medicine, Kurume University School of Medicine, Kurume 830-0011, Japan
M. SOEJIMA
Affiliation:
Division of Human Genetics, Department of Forensic Medicine, Kurume University School of Medicine, Kurume 830-0011, Japan
N. FUJITANI
Affiliation:
Division of Human Genetics, Department of Forensic Medicine, Kurume University School of Medicine, Kurume 830-0011, Japan
T. OGAKI
Affiliation:
Institute of Health Science, Kyushu University, Kasuga 816-0811, Japan
A. SAITO
Affiliation:
Institute of Health Science, Kyushu University, Kasuga 816-0811, Japan
T. KAWASAKI
Affiliation:
Institute of Health Science, Kyushu University, Kasuga 816-0811, Japan
H. KIMURA
Affiliation:
Division of Human Genetics, Department of Forensic Medicine, Kurume University School of Medicine, Kurume 830-0011, Japan
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Abstract

The polymorphic alleles of the human ABO-Secretor locus (FUT2 or Se) show high heterogeneity and overt ethnic specificity. To provide additional data for analysis to elucidate the origins of populations, we have investigated the allelic polymorphism of FUT2 in 40 unrelated Tibetan and 53 Tamang individuals from Nepal, 42 Indonesian individuals from Surabaya, and 55 Uygur individuals from Urumqi, using DNA sequencing. In Tibetan, Tamang and Indonesian populations, the frequency of a nonfunctional allele, se357,385, which is found only in Asian populations, was 0·638, 0·509 and 0·631, respectively. In Uygur, the se428, which is common in Caucasian populations, and the se357,385 consisting of two common nonfunctional FUT2 alleles, had frequencies of 0·3 and 0·145, respectively. The fixation index (FST) based on genetic differentiation was obtained pairwise among the four populations in this study and six populations in our previous studies. The results suggested that genetic differentiation among Tibetan, Tamang, Indonesian and East Asian populations is very low, while the distribution feature of the FUT2 alleles in the Uygur population implied an admixture of European with Asian. The distribution of nonfunctional alleles at the FUT2 locus provided further evidence of human migration among the Asian populations.

Type
Review Article
Information
Annals of Human Genetics , Volume 65 , Issue 5 , September 2001 , pp. 429 - 437
Copyright
University College London 2001

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