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HLA evidence for the lack of genetic heterogeneity in Basques

Published online by Cambridge University Press:  01 March 1998

D. COMAS ,
F. CALAFELL ,
E. MATEU ,
A. PÉREZ-LEZAUN  and
J. BERTRANPETIT
D. COMAS
Affiliation:
Unitat d'Antropologia, Departament de Biologia Animal, Facultat de Biologia, Universitat de Barcelona, Avinguda Diagonal 645, 08028 Barcelona, Spain
F. CALAFELL
Affiliation:
Unitat d'Antropologia, Departament de Biologia Animal, Facultat de Biologia, Universitat de Barcelona, Avinguda Diagonal 645, 08028 Barcelona, Spain Present address: Department of Genetics, School of Medicine, Yale University, USA.
E. MATEU
Affiliation:
Unitat d'Antropologia, Departament de Biologia Animal, Facultat de Biologia, Universitat de Barcelona, Avinguda Diagonal 645, 08028 Barcelona, Spain
A. PÉREZ-LEZAUN
Affiliation:
Unitat d'Antropologia, Departament de Biologia Animal, Facultat de Biologia, Universitat de Barcelona, Avinguda Diagonal 645, 08028 Barcelona, Spain
J. BERTRANPETIT
Affiliation:
Unitat d'Antropologia, Departament de Biologia Animal, Facultat de Biologia, Universitat de Barcelona, Avinguda Diagonal 645, 08028 Barcelona, Spain
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Abstract

To examine the possible internal heterogeneity within the Basque population, nine samples typed for several HLA loci were compiled and HLA-A, B, C and DR loci were analysed. First, the shared features of HLA in Basques were analysed by principal component analysis and genetic distances. Two major Basque dialect groups (‘French’ and ‘Spanish’) were considered. FST statistics were computed and corrected for sampling intensity. The dialectal and political division did not seem to differentiate these two groups genetically. Analysis of Molecular Variance also failed to show consistently significant genetic variance components between French and Spanish Basques. Thus, in this particular example, linguistic diversity does not seem to correlate with a genetic stratification.

Type
Research Article
Information
Annals of Human Genetics , Volume 62 , Issue 2 , March 1998 , pp. 123 - 132
Copyright
© University College London 1998

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