Hostname: page-component-78c5997874-t5tsf Total loading time: 0 Render date: 2024-11-20T05:17:36.023Z Has data issue: false hasContentIssue false
  • English
  • Français

Supplementation of grazing beef cows during gestation as a strategy to improve skeletal muscle development of the offspring

Published online by Cambridge University Press:  02 June 2017

D. C. Marquez ,
M. F. Paulino ,
L. N. Rennó ,
F. C. Villadiego ,
R. M. Ortega ,
D. S. Moreno ,
L. S. Martins ,
D. M. de Almeida ,
M. P. Gionbelli  and
M. R. Manso
...Show all authors
D. C. Marquez*
Affiliation:
Department of Animal Science, Universidade Federal de Viçosa, 36570-000, Viçosa, Minas Gerais, Brasil
M. F. Paulino
Affiliation:
Department of Animal Science, Universidade Federal de Viçosa, 36570-000, Viçosa, Minas Gerais, Brasil
L. N. Rennó
Affiliation:
Department of Animal Science, Universidade Federal de Viçosa, 36570-000, Viçosa, Minas Gerais, Brasil
F. C. Villadiego
Affiliation:
Department of Veterinary Medicine, Universidade Federal de Viçosa, 36570-000, Viçosa, Minas Gerais, Brasil
R. M. Ortega
Affiliation:
Department of Animal Science, Universidade Federal de Viçosa, 36570-000, Viçosa, Minas Gerais, Brasil
D. S. Moreno
Affiliation:
Department of Animal Science, Universidade Federal de Viçosa, 36570-000, Viçosa, Minas Gerais, Brasil
L. S. Martins
Affiliation:
Department of Animal Science, Universidade Federal de Viçosa, 36570-000, Viçosa, Minas Gerais, Brasil
D. M. de Almeida
Affiliation:
Department of Animal Science, Universidade Federal de Viçosa, 36570-000, Viçosa, Minas Gerais, Brasil
M. P. Gionbelli
Affiliation:
Department of Animal Science, Universidade Federal de Lavras, 37200-000, Lavras, Minas Gerais, Brasil
M. R. Manso
Affiliation:
Department of Animal Science, Universidade Federal de Viçosa, 36570-000, Viçosa, Minas Gerais, Brasil
L. P. Melo
Affiliation:
Department of Animal Science, Universidade Federal de Viçosa, 36570-000, Viçosa, Minas Gerais, Brasil
F. H. Moura
Affiliation:
Department of Animal Science, Universidade Federal de Viçosa, 36570-000, Viçosa, Minas Gerais, Brasil
M. S. Duarte
Affiliation:
Department of Animal Science, Universidade Federal de Viçosa, 36570-000, Viçosa, Minas Gerais, Brasil
*
†E-mail: [email protected]
Get access

Abstract

The appropriate supply of nutrients in pregnant cows has been associated with the optimal development of foetal tissues, performance of their progeny and their meat quality. The aim of this study was to evaluate supplementation effects of grazing cows in different stages of gestation on skeletal muscle development and performance of the progeny. Thereby, 27 Nellore cows were divided into three groups (n=9 for each group) and their progeny as follows: UNS, unsupplemented during gestation; MID, supplemented from 30 to 180 days of gestation; LATE, supplemented from 181 to 281 days of gestation. The percentage composition of the supplement provided for the matrices was the following: ground corn (26.25%), wheat bran (26.25%) and soya bean meal (47.5%). The supplement was formulated to contain 30% CP. Supplemented matrices received 150 kg of supplement (1 and 1.5 kg/day for cows in the MID and LATE groups, respectively). After birth, a biopsy was performed to obtain samples of skeletal muscle tissue from calves to determine number and size of muscle fibres and for messenger RNA (mRNA) expression analysis. The percentage composition of the supplement provided for the progeny was the following: ground corn grain (30%), wheat bran (30%), soya bean meal (35%) and molasses (5%). The supplement was formulated to contain 25% CP and offered in an amount of 6 g/kg BW. Performance of the progeny was monitored throughout the suckling period. Means were submitted to ANOVA and regression, and UNS, MID and LATE periods of supplementation were compared. Differences were considered at P<0.10. Birth weight, average daily gain and weaning weight of the offspring did not differ among treatments (P>0.10). Similarly, no differences were observed between calves for nutrient intake (P>0.10). However, greater subcutaneous fat thickness (P=0.006) was observed in the calves of LATE group. The ribeye area (P=0.077) was greater in calves born from supplemented compared with UNS cows. The supplementation of pregnant cows did not affect the muscle fibre size of their progeny (P=0.208). On the other hand, calves born from dams supplemented at mid-gestation had greater muscle fibre number (P=0.093) compared with calves from UNS group. Greater mRNA expression of peroxysome proliferator-activated receptor α (P=0.073) and fibroblast growth factor 2 (P=0.003) was observed in the calves born from MID cows. Although strategic supplementation did not affect the BW of offspring, it did cause changes in carcass traits, number of myofibres, and mRNA expression of a muscle hypertrophy and lipid oxidation markers in skeletal muscle of the offspring.

Keywords

adipogenesishyperplasiafoetal programmingmyogenesispregnancy
Type
Research Article
Information
animal , Volume 11 , Issue 12 , December 2017 , pp. 2184 - 2192
Copyright
© The Animal Consortium 2017 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Allen, RE and Rankin, LL 1990. Regulation of satellite cells during skeletal muscle growth and development. Proceedings of the Society for Experimental Biology and Medicine 194, 81–86.CrossRefGoogle ScholarPubMed
Aragão, R, Guzman, Q, Perez, G, Manhaes, C and Bolanos, J 2014. Maternal protein restriction impairs the transcriptional metabolic flexibility of skeletal muscle in adult rat offspring. British Journal of Nutrition 112, 328–337.CrossRefGoogle Scholar
Arrigoni, MB, Júnior, AA, Dias, PMA, Ludovico, C, Cervieri, RC, Silveira, AC, Oliveira, HN and Chardulo, LAL 2004. Desempenho, fibras musculares e carne de bovinos jovens de três grupos genéticos. Pesquisa Agropecuária Brasileira 39, 1033–1039.CrossRefGoogle Scholar
Association of Official Analytical Chemists and Helrich, K 1990. Official methods of analysis of the Association of Official Analytical Chemists, 15th edition. AOAC, Arlington, VA, USA.Google Scholar
Biswas, D, Ghosh, M, Kumar, S and Chakrabarti, P 2016. PPARalpha-ATGL pathway improves muscle mitochondrial metabolism: implication in aging. The FASEB Journal 30, 3822–3834.CrossRefGoogle ScholarPubMed
Bonnet, M, Cassar, M, Chilliard, Y and Picard, B 2010. Ontogenesis of muscle and adipose tissues and their interactions in ruminants and other species. Animal 4, 1093–1109.CrossRefGoogle ScholarPubMed
Bustin, SA 2002. Quantification of mRNA using real-time reverse transcription PCR (RT-PCR): trends and problems. Molecular Endocrinology 29, 23–39.CrossRefGoogle ScholarPubMed
Detmann, E, Paulino, MF, Zervoudakis, JT, Valadares Filho, SdC, Euclydes, RF, Lana, RdP and Queiroz, DSd 2001a. Cromo e indicadores internos na determinação do consumo de novilhos mestiços, suplementados, a pasto. Revista Brasileira de Zootecnia 30, 1600–1609.CrossRefGoogle Scholar
Detmann, E, Paulino, MF, Zervoudakis, JT, Valadares Filho, SdC, Lana, RdP and Queiroz, DSd 2001b. Suplementação de novilhos mestiços durante a época das águas: parâmetros ingestivos e digestivos. Revista Brasileira de Zootecnia 30, 1340–1349.CrossRefGoogle Scholar
Du, M, Tong, J, Zhao, J, Underwood, KR, Zhu, M, Ford, SP and Nathanielsz, PW 2010. Fetal programming of skeletal muscle development in ruminant animals. Journal of Animal Science 88, 51–60.CrossRefGoogle ScholarPubMed
Du, M, Huang, Y, Das, AK, Yang, Q, Duarte, MS, Dodson, MV and Zhu, MJ 2013. Meat Science and Muscle Biology Symposium: manipulating mesenchymal progenitor cell differentiation to optimize performance and carcass value of beef cattle. Journal of Animal Science 91, 1419–1427.CrossRefGoogle ScholarPubMed
Du, M, Zhao, JX, Yan, X, Huang, Y, Nicodemus, LV, Yue, W, McCormick, RJ and Zhu, MJ 2011. Fetal muscle development, mesenchymal multipotent cell differentiation, and associated signaling pathways. Journal of Animal Science 89, 583–590.CrossRefGoogle ScholarPubMed
Duarte, MS, Bueno, R, Silva, W, Campos, C, Gionbelli, MP, Guimarães, SEF, Silva, F, Lopes, P, Hausman, GJ and Dodson, MV 2017. Dedifferentiated fat (DFAT) cells: potentialities and perspectives for its use in clinical and animal science purpose. Journal of Animal Science. First published online 03 January 2017, doi:10.2527/jas2016.CrossRefGoogle Scholar
Duarte, MS, Gionbelli, MP, Paulino, PVR, Serão, NVL, Nascimento, CS, Botelho, ME, Martins, TS, Filho, SCV, Dodson, MV, Guimarães, SEF and Du, M 2014. Maternal overnutrition enhances mRNA expression of adipogenic markers and collagen deposition in skeletal muscle of beef cattle fetuses. Journal of Animal Science 92, 3846–3854.CrossRefGoogle ScholarPubMed
Duarte, MS, Paulino, PV, Das, AK, Wei, S, Serao, NV, Fu, X, Harris, SM, Dodson, MV and Du, M 2013. Enhancement of adipogenesis and fibrogenesis in skeletal muscle of Wagyu compared with Angus cattle. Journal of Animal Science 91, 2938–2946.CrossRefGoogle ScholarPubMed
Huang, Y, Zhao, JX, Yan, X, Zhu, MJ, Long, NM, McCormick, RJ, Ford, SP, Nathanielsz, PW and Du, M 2012. Maternal obesity enhances collagen accumulation and cross-linking in skeletal muscle of ovine offspring. PLoS ONE 7, 1–8.Google ScholarPubMed
Jennings, TD, Gonda, MG, Underwood, KR, Wertz, L and Blair, AD 2016. The influence of maternal nutrition on expression of genes responsible for adipogenesis and myogenesis in the bovine fetus. Animal 10, 1697–1705.CrossRefGoogle ScholarPubMed
Lopes, SA, Paulino, MF, Detmann, E, de Campos, VF, Valente, EE, Barros, LV, Cardenas, JE, Almeida, DM, Martins, LS and Silva, AG 2014. Supplementation of suckling beef calves with different levels of crude protein on tropical pasture. Tropical Animal Health and Production 46, 379–384.CrossRefGoogle ScholarPubMed
Martins, TS, Sanglard, LMP, Silva, W, Chizzotti, ML, Rennó, LN, Serão, NVL, Silva, FF, Guimarães, SEF, Ladeira, MM, Dodson, MV, Du, M and Duarte, MS 2015. Molecular factors underlying the deposition of intramuscular fat and collagen in skeletal muscle of Nellore and Angus cattle. PLoS ONE 10, 1–13.CrossRefGoogle ScholarPubMed
Mertens, DR 2002. Gravimetric determination of amylase-treated neutral detergent fiber in feeds with refluxing in beakers or crucibles: collaborative study. Journal of AOAC International 85, 1217–1240.Google ScholarPubMed
Mitchell, P, Steenstrup, T and Hannon, K 1999. Expression of fibroblast growth factor family during postnatal skeletal muscle hypertrophy. Journal of Applied Physiology 86, 313–319.CrossRefGoogle ScholarPubMed
Nolan, T, Hands, RE and Bustin, SA 2006. Quantification of mRNA using real-time RT-PCR. Journal of Nature Protocols 1, 1559–1582.CrossRefGoogle ScholarPubMed
Ozanne, SE, Olsen, GS, Hansen, LL, Tingey, KJ, Nave, BT, Wang, CL, Hartil, K, Petry, CJ, Buckley, AJ and Mosthaf, SL 2003. Early growth restriction leads to down regulation of protein kinase C zeta and insulin resistance in skeletal muscle. Journal of Endocrinology 177, 235–241.CrossRefGoogle ScholarPubMed
Paulino, MF, Detmann, E and Valadares, SdC 2008. Simpósio internacional de produção de gado de corte, 6th edition. SIMCORTE, Viçosa, MG, BR.Google Scholar
Picard, B, Lefaucheur, L, Berri, C and Duclos, MJ 2002. Muscle fibre ontogenesis in farm animal species. Reproduction, Nutrition, Development 42, 415–431.CrossRefGoogle ScholarPubMed
Raja, JS, Hoffman, ML, Govoni, KE, Zinn, SA and Reed, SA 2016. Restricted maternal nutrition alters myogenic regulatory factor expression in satellite cells of ovine offspring. Animal 10, 1200–1203.CrossRefGoogle ScholarPubMed
Russell, RG and Oteruelo, FT 1981. An ultrastructural study of the differentiation of skeletal muscle in the bovine fetus. Anatomy and Embryology 162, 403–417.CrossRefGoogle ScholarPubMed
Schindelin, J, Rueden, CT, Hiner, MC and Eliceiri, KW 2015. The ImageJ ecosystem: an open platform for biomedical image analysis. Molecular Reproduction and Development 82, 518–529.CrossRefGoogle ScholarPubMed
Selak, MA, Storey, BT, Peterside, I and Simmons, RA 2003. Impaired oxidative phosphorylation in skeletal muscle of intrauterine growth-retarded rats. American Journal of Physiology, Endocrinology and Metabolism 285, E130–E137.CrossRefGoogle ScholarPubMed
Timm, LdL 2005. Técnicas rotineiras de preparação e análise de lâminas histológicas. In Caderno La Salle XI (ed. SciELO Brasil), 1st edition, pp. 231–239. Brasil, Canoas.Google Scholar
Titgemeyer, EC, Armendariz, CK, Bindel, DJ, Greenwood, RH and Loest, CA 2001. Evaluation of titanium dioxide as a digestibility marker for cattle. Journal of Animal Science 79, 1059–1063.CrossRefGoogle ScholarPubMed
Uezumi, A, Ito, T, Morikawa, D, Shimizu, N, Yoneda, T, Segawa, M, Yamaguchi, M, Ogawa, R, Matev, MM, Miyagoe, SY, Takeda, S, Tsujikawa, K, Tsuchida, K, Yamamoto, H and Fukada, S 2011. Fibrosis and adipogenesis originate from a common mesenchymal progenitor in skeletal muscle. Journal of Cell Science 124, 3654–3664.CrossRefGoogle ScholarPubMed
Valente, TNP, Detmann, E, Queiroz, AC, Valadares, F, Gomes, DI and Figueiras, JF 2011. Evaluation of ruminal degradation profiles of forages using bags made from different textiles. Revista Brasileira de Zootecnia 40, 2565–2573.CrossRefGoogle Scholar
Van Soest, PJ and Robertson, J 1985. Analysis of forages and fibrous foods. AS 613 manual. Department of Animal Science, Cornell University, Ithaca, NY, USA.Google Scholar
Williams, CH, David, DJ and Iismaa, O 1962. The determination of chromic oxide in faeces samples by atomic absorption spectrophotometry. The Journal of Agricultural Science 59, 381–385.CrossRefGoogle Scholar
Zhu, MJ, Ford, SP, Means, WJ, Hess, BW, Nathanielsz, PW and Du, M 2006. Maternal nutrient restriction affects properties of skeletal muscle in offspring. The Journal of Physiology 575, 241–250.CrossRefGoogle ScholarPubMed
Zhu, MJ, Ford, SP, Nathanielsz, PW and Du, M 2004. Effect of maternal nutrient restriction in sheep on the development of fetal skeletal muscle. Biology of Reproduction 71, 1968–1973.CrossRefGoogle ScholarPubMed