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Review: Animal model and the current understanding of molecule dynamics of adipogenesis

Published online by Cambridge University Press:  18 January 2016

C. F. Campos ,
M. S. Duarte ,
S. E. F. Guimarães ,
L. L. Verardo ,
S. Wei ,
M. Du ,
Z. Jiang ,
W. G. Bergen ,
G. J. Hausman  and
M. Fernyhough-Culver
...Show all authors
C. F. Campos*
Affiliation:
Department of Animal Sciences, Universidade Federal de Viçosa, Viçosa, MG 36570-000, Brazil Department of Animal Sciences, Washington State University, Pullman, WA 99164, USA LABTEC-Animal Biotechnology Laboratory, Universidade Federal de Viçosa, Viçosa, MG 36570-000, Brazil
M. S. Duarte
Affiliation:
Department of Animal Sciences, Universidade Federal de Viçosa, Viçosa, MG 36570-000, Brazil LABTEC-Animal Biotechnology Laboratory, Universidade Federal de Viçosa, Viçosa, MG 36570-000, Brazil
S. E. F. Guimarães
Affiliation:
Department of Animal Sciences, Universidade Federal de Viçosa, Viçosa, MG 36570-000, Brazil LABTEC-Animal Biotechnology Laboratory, Universidade Federal de Viçosa, Viçosa, MG 36570-000, Brazil
L. L. Verardo
Affiliation:
Department of Animal Sciences, Universidade Federal de Viçosa, Viçosa, MG 36570-000, Brazil LABTEC-Animal Biotechnology Laboratory, Universidade Federal de Viçosa, Viçosa, MG 36570-000, Brazil
S. Wei
Affiliation:
College of Animal Science and Technology, Nanjing Agricultural University, Nanjing, Jiangsu 210095, PR China
M. Du
Affiliation:
Department of Animal Sciences, Washington State University, Pullman, WA 99164, USA
Z. Jiang
Affiliation:
Department of Animal Sciences, Washington State University, Pullman, WA 99164, USA
W. G. Bergen
Affiliation:
Department of Animal Sciences, Auburn University, Auburn, AL 36849-5415, USA
G. J. Hausman
Affiliation:
Department of Animal and Dairy Science, University of Georgia, Athens, GA 30602, USA
M. Fernyhough-Culver
Affiliation:
Albitec Corporation, Columbus, OH 43215, USA
E. Albrecht
Affiliation:
Leibniz Institute for Farm Animal Biology, Wilhelm-Stahl-Allee 2, 18196 Dummerstorf, Germany
M. V. Dodson
Affiliation:
Department of Animal Sciences, Washington State University, Pullman, WA 99164, USA
*
†E-mail: [email protected]
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Abstract

Among several potential animal models that can be used for adipogenic studies, Wagyu cattle is the one that presents unique molecular mechanisms underlying the deposit of substantial amounts of intramuscular fat. As such, this review is focused on current knowledge of such mechanisms related to adipose tissue deposition using Wagyu cattle as model. So abundant is the lipid accumulation in the skeletal muscles of these animals that in many cases, the muscle cross-sectional area appears more white (adipose tissue) than red (muscle fibers). This enhanced marbling accumulation is morphologically similar to that seen in numerous skeletal muscle dysfunctions, disease states and myopathies; this might indicate cross-similar mechanisms between such dysfunctions and fat deposition in Wagyu breed. Animal models can be used not only for a better understanding of fat deposition in livestock, but also as models to an increased comprehension on molecular mechanisms behind human conditions. This revision underlies some of the complex molecular processes of fat deposition in animals.

Keywords

wagyuadipogenesislipodystrophiesobesity
Type
Review Article
Information
animal , Volume 10 , Issue 6 , June 2016 , pp. 927 - 932
Copyright
© The Animal Consortium 2016 

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