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Natural alternatives to in-feed antibiotics in pig production: can immunomodulators play a role?

Published online by Cambridge University Press:  13 March 2009

M. Gallois ,
H. J. Rothkötter ,
M. Bailey ,
C. R. Stokes  and
I. P. Oswald
M. Gallois
Affiliation:
INRA, UR66, Laboratoire de Pharmacologie-Toxicologie, Centre de Recherche de Toulouse, BP3 31931, Toulouse cedex 9, France
H. J. Rothkötter
Affiliation:
Institut für Anatomie, Medizinische Fakultaet, Otto-von-Guericke-Universitaet Magdeburg, Leipziger Strasse 44, 39120 Magdeburg, Germany
M. Bailey
Affiliation:
Division of Veterinary Pathology Infection & Immunity, University of Bristol, Langford House, Langford BS40 5DU, UK
C. R. Stokes
Affiliation:
Division of Veterinary Pathology Infection & Immunity, University of Bristol, Langford House, Langford BS40 5DU, UK
I. P. Oswald*
Affiliation:
INRA, UR66, Laboratoire de Pharmacologie-Toxicologie, Centre de Recherche de Toulouse, BP3 31931, Toulouse cedex 9, France
*
E-mail: [email protected]
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Abstract

As a result of the European ban of in-feed growth-promoting antibiotics, new strategies are being developed to increase the resistance to disease in farm animals. In pig production, this is of particular importance during the weaning transition when piglets are subjected to major stressful events, making them highly sensitive to digestive disorders. At this time, the development of both innate and adaptive immunity at the mucosal surface is critical in preventing the potential harmful effects of intestinal pathogenic agents. Strategies aiming at stimulating natural host defences through the use of substances able to modulate immune functions have gained increasing interest in animal research, and different bioactive components a priori sharing those properties have been the subject of in vivo nutritional investigations in pig. Among these, yeast derivates (β-glucans and mannans) are able to interact with immune cells, particularly phagocytic cells. However, studies where they have been fed to pigs have shown inconsistent results, suggesting that their ability to target the sensitive immune cells through the oral route is questionable. The plant extracts, which would benefit from a positive image in the public opinion, have also been tested. However, due to a lack of data on the bioactive components of particular plants and the large diversity of species, it has proved difficult to prepare extracts of equivalent potency and thus, the literature on their influence on pig immunity remains inconclusive. In considering piglet immunity and health benefits, the most promising results to date have been obtained with spray-dried animal plasma, whose positive effects would be provided by specific antibodies and non-specific competition of some plasma components with bacteria for intestinal receptors. The major positive effect of spray-dried animal plasma is in reducing the infiltration of gut-associated lymphoid tissue by immune cells, which is likely to be the result of a decreased colonisation by potentially harmful bacteria. This review also highlights the limitations of some of the published in vivo studies on the immunomodulatory activity of certain feed additives. Among those, the lack of standardisation of extracts and the heterogeneity of piglet-rearing conditions (e.g. exposure to pathogens) are likely the most limiting.

Keywords

pigimmunitydisease sensitivityfeed additiveimmunomodulators
Type
Full Paper
Information
animal , Volume 3 , Issue 12 , December 2009 , pp. 1644 - 1661
Copyright
Copyright © The Animal Consortium 2009

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