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Lower serum IgA levels in horses kept under intensive sanitary management and physical training

Published online by Cambridge University Press:  22 June 2010

C. M. Souza ,
B. A. Miotto ,
C. P. Bonin  and
M. M. Camargo
C. M. Souza
Affiliation:
Department of Immunology, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, 05508-000, Brazil
B. A. Miotto
Affiliation:
Department of Immunology, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, 05508-000, Brazil
C. P. Bonin
Affiliation:
Department of Immunology, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, 05508-000, Brazil
M. M. Camargo*
Affiliation:
Department of Immunology, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, 05508-000, Brazil
*
†E-mail: mmcamar@usp.br
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Abstract

Quantity and variety of environmental antigens, age, diet, vaccine protocols, exercising practice and mucosal cytokine microenvironment are factors that influence serum immunoglobulin (Ig) levels. IgA, IgG, IgG(T) and IgM were quantified in 60 horses, which were classified into two groups, ‘intensive’ or ‘relaxed’, according to sanitary standards of the facilities and physical exercise to which animals were subjected to. The ‘intensive’ group presented lower means for all isotypes, but only IgA presented a significant (P < 0.0064) difference when compared to the ‘relaxed’ group. This suggests that mucosal immunity found in the ’intensive’ group is lower when compared to the ‘relaxed’ group. Our data suggest that athlete horses may be less poised to mount an effective mucosal immunity response to environmental challenges and should not be considered by the same perspectives as a free-ranging horse.

Keywords

environmental antigen, horse, immunoglobulin A, mucosal immunity, exercise
Type
Full Paper
Information
animal , Volume 4 , Issue 12 , December 2010 , pp. 2080 - 2083
Copyright
Copyright © The Animal Consortium 2010

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