Hostname: page-component-586b7cd67f-rdxmf Total loading time: 0 Render date: 2024-11-30T23:54:44.608Z Has data issue: false hasContentIssue false
  • English
  • Français

Lower serum IgA levels in horses kept under intensive sanitary management and physical training

Published online by Cambridge University Press:  22 June 2010

C. M. Souza ,
B. A. Miotto ,
C. P. Bonin  and
M. M. Camargo
C. M. Souza
Affiliation:
Department of Immunology, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, 05508-000, Brazil
B. A. Miotto
Affiliation:
Department of Immunology, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, 05508-000, Brazil
C. P. Bonin
Affiliation:
Department of Immunology, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, 05508-000, Brazil
M. M. Camargo*
Affiliation:
Department of Immunology, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, 05508-000, Brazil
*
†E-mail: [email protected]
Get access

Abstract

Quantity and variety of environmental antigens, age, diet, vaccine protocols, exercising practice and mucosal cytokine microenvironment are factors that influence serum immunoglobulin (Ig) levels. IgA, IgG, IgG(T) and IgM were quantified in 60 horses, which were classified into two groups, ‘intensive’ or ‘relaxed’, according to sanitary standards of the facilities and physical exercise to which animals were subjected to. The ‘intensive’ group presented lower means for all isotypes, but only IgA presented a significant (P < 0.0064) difference when compared to the ‘relaxed’ group. This suggests that mucosal immunity found in the ’intensive’ group is lower when compared to the ‘relaxed’ group. Our data suggest that athlete horses may be less poised to mount an effective mucosal immunity response to environmental challenges and should not be considered by the same perspectives as a free-ranging horse.

Keywords

environmental antigen, horse, immunoglobulin A, mucosal immunity, exercise
Type
Full Paper
Information
animal , Volume 4 , Issue 12 , December 2010 , pp. 2080 - 2083
Copyright
Copyright © The Animal Consortium 2010

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Al-Ani, FK, al-Darraji, AM, Lafi, SQ, Hailat, NQ 1997. Equine babesiosis associated with strenuous exercise: clinical and pathological studies in Jordan. Veterinary Parasitology 69, 1–8.Google Scholar
Bos, NA, Meeuwsen, CG, Wostmann, BS, Pleasants, JR, Benner, R 1988. The influence of exogenous antigenic stimulation on the specificity repertoire of background immunoglobulin-secreting cells of different isotypes. Cellular Immunology 112, 371–380.CrossRefGoogle ScholarPubMed
Cerutti, A 2008. The regulation of IgA class switching. Nature Reviews Immunology 8, 421–434.CrossRefGoogle ScholarPubMed
Flaminio, MJBF, Tallmadge, RL, Salles-Gomes, COM, Matychak, MB 2009. Common variable immunodeficiency in horses is characterized by B cell depletion in primary and secondary lymphoid tissues. Journal of Clinical Immunology 29, 107–116.CrossRefGoogle Scholar
Foote, CE, Love, DN, Gilkerson, JR, Rota, J, Trevor-Jones, P, Ruitenberg, KM, Wellington, JE, Whalley, JM 2005. Serum antibody responses to equine herpesvirus 1 glycoprotein D in horses, pregnant mares and young foals. Veterinary Immunology and Immunopathology 105, 47–57.CrossRefGoogle ScholarPubMed
Gleeson, M, Pyne, DB 2000. Special feature for the Olympics: effects of exercise on the immune system: exercise effects on mucosal immunity. Immunology and Cell Biology 78, 536–544.CrossRefGoogle ScholarPubMed
Gleeson, M, McDonald, WA, Cripps, AW, Pyne, DB, Clancy, RL, Fricker, PA 1995. The effect on immunity of long-term intensive training in elite swimmers. Clinical and Experimental Immunology 102, 210–216.CrossRefGoogle ScholarPubMed
Hines, MT, Schott, HC 2nd, Bayly, WM, Leroux, AJ 1996. Exercise and immunity: a review with emphasis on the horse. Journal of Veterinary Internal Medicine 10, 280–289.CrossRefGoogle ScholarPubMed
Mackinnon, LT 2000. Chronic exercise training effects on immune function. Medicine Science Sports and Exercise 32, S369–S376.CrossRefGoogle ScholarPubMed
Malinowski, K, Kearns, CF, Guirnalda, PD, Roegner, V, McKeever, KH 2004. Effect of chronic clenbuterol administration and exercise training on immune function in horses. Journal of Animal Science 82, 3500–3507.CrossRefGoogle ScholarPubMed
Menezes, JS, Andrade, MC, Senra, B, Rodrigues, VS, Vaz, NM, Faria, AMC 2006. Immunological activities are modulated by enteral administration of an elemental diet in mice. Clinical Nutrition 25, 643–652.CrossRefGoogle ScholarPubMed
Menezes, JS, Mucida, DS, Cara, DC, Alvarez-Leite, JI, Russo, M, Vaz, NM, Faria, AMC 2003. Stimulation by food proteins plays a critical role in the maturation of the immune system. International Immunology 15, 447–455.CrossRefGoogle Scholar
Tallmadge, RL, McLaughlin, K, Secor, E, Ruano, D, Matychak, MB, Flaminio, MJBF 2009. Expression of essential B cell genes and immunoglobulin isotypes suggests active development and gene recombination during equine gestation. Developmental and Comparative Immunology 33, 1027–1038.CrossRefGoogle ScholarPubMed
Timoney, JF, Holmes, MA, Sponseller, BT, Sheoran, AS 1997. Serum and mucosal antibody isotype responses to M-like protein (SeM) of streptococcus equi in convalescent and vaccinated horses. Veterinary Immunology and Immunopathology 59, 239–251.Google Scholar
Vara, E, Marañon, G, Castejon, F, Sánchez de la Muela, M, Olabarri, B, Manley, W, Dominguez, C, Muñoz-Escassi, B, Cayado, P 2006. Hormone response to training and competition in athletic horses. Equine Veterinary Journal 36, 274–278.Google Scholar