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Genome-wide association study for longevity in the Holstein cattle population

Published online by Cambridge University Press:  03 December 2018

R. Steri ,
B. Moioli Open the ORCID record for B. Moioli [Opens in a new window] ,
G. Catillo ,
A. Galli  and
L. Buttazzoni
R. Steri
Affiliation:
Consiglio per la ricerca in agricoltura e l’analisi dell’economia agraria (CREA), via Salaria 31, 00015 Monterotondo, Italy
B. Moioli*
Affiliation:
Consiglio per la ricerca in agricoltura e l’analisi dell’economia agraria (CREA), via Salaria 31, 00015 Monterotondo, Italy
G. Catillo
Affiliation:
Consiglio per la ricerca in agricoltura e l’analisi dell’economia agraria (CREA), via Salaria 31, 00015 Monterotondo, Italy
A. Galli
Affiliation:
Istituto Sperimentale Italiano Lazzaro Spallanzani, Loc. La Quercia, 26027 Rivolta d’Adda, Italy Consiglio per la ricerca in agricoltura e l’analisi dell’economia agraria (CREA), viale Piacenza 29, 26900 Lodi, Italy
L. Buttazzoni
Affiliation:
Consiglio per la ricerca in agricoltura e l’analisi dell’economia agraria (CREA), via Salaria 31, 00015 Monterotondo, Italy
*
†E-mail: [email protected]
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Abstract

Longevity is one of the most important traits determining dairy cow profitability. In the last decades dairy cows suffered a lowering in the age at culling. With the aim to identify the genes involved in longevity, dates of birth, yields, dates of calving during lifespan and culling dates were collected for 946 culled cows which had been genotyped with the Bovine High Density panel. Using the GenABEL package in R, genome-wide association analysis was performed on three potential traits of longevity: (1) ‘days in production,’ (2) ‘days in herd,’ (3) number of calvings over lifespan.’ Five genome-wide significant single nucleotide polymorphisms (SNPs) associated with all three longevity traits were detected. Several consecutive SNPs identified on chromosomes 16 and 30 indicated the presence of two suggestive quantitative trait loci (QTL). The genes comprised in the QTL regions had biological functions related to fertility, reproductive disorders, heat stress and welfare of cows. These findings might contribute to improving breeding strategies to improve longevity.

Keywords

dairy cowslongevityresiliencegenome-wide studyfertility
Type
Research Article
Information
animal , Volume 13 , Issue 7 , July 2019 , pp. 1350 - 1357
Copyright
© The Animal Consortium 2018 

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