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Effects of maternal nutrient restriction during early or mid-gestation without realimentation on maternal physiology and foetal growth and development in beef cattle

Published online by Cambridge University Press:  12 July 2017

R. K. Taylor ,
C. T. LeMaster ,
K. S. Mangrum ,
R. E. Ricks  and
N. M. Long
R. K. Taylor
Affiliation:
Department of Animal and Veterinary Sciences, Clemson University, Clemson, South Carolina 29634, USA
C. T. LeMaster
Affiliation:
Department of Animal and Veterinary Sciences, Clemson University, Clemson, South Carolina 29634, USA
K. S. Mangrum
Affiliation:
Department of Animal and Veterinary Sciences, Clemson University, Clemson, South Carolina 29634, USA
R. E. Ricks
Affiliation:
Department of Animal and Veterinary Sciences, Clemson University, Clemson, South Carolina 29634, USA
N. M. Long*
Affiliation:
Department of Animal and Veterinary Sciences, Clemson University, Clemson, South Carolina 29634, USA
*
†E-mail: [email protected]
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Abstract

The aim of this study is to determine the effects of early and mid-gestation nutrient restriction on maternal metabolites and foetal growth. Primiparous Angus cows were synchronized and inseminated with semen from one sire. Dietary treatments were: control to gain 1 kg/week (CON) or 0.55% maintenance energy and CP requirements (nutrient restricted; NR). A subset of dams was fed NR (n=8) or CON (n=8) from days 30 to 110 of gestation. Another group was fed CON (n=8), days 30 to 190; NR (n=7), days 30 to 110 followed by CON days 110 to 190; or CON, (n=7) days 30 to 110 followed by NR days 110 to 190. Cows were harvested at days 110 or 190 of gestation, when foetal measurements and samples were collected. Cows that were NR during days 30 to 110 or 110 to 190 of gestation lost significant BW and body condition score (P<0.001), this was associated with reduced plasma glucose during NR (P<0.002). Foetal weights, empty foetal weights, abdominal and thoracic circumferences were all reduced (P<0.03) in day 110 NR animals. Foetal perirenal adipose as a percentage of empty foetal weight was increased (P=0.01) in NR day 110 female foetuses compared with CON foetus. Maternal serum triglycerides at day 110 of gestation were decreased (P<0.05) in NR dams, whereas foetal serum triglycerides were increased (P<0.05) in response to maternal NR. Foetal weights tended to be reduced (P=0.08) in NR/CON and CON/NR v. CON/CON cattle at day 190 of gestation. Empty foetal weights, abdominal and thoracic circumferences were reduced (P⩽0.03) in NR/CON and CON/NR v. CON/CON cattle. Brain weight as a percentage of empty foetal weight was increased (P<0.001) in NR/CON and CON/NR v. CON/CON cattle. Foetal perirenal adipose as a percentage of empty foetal weight was increased (P=0.003) in NR/CON and CON/NR v. CON/CON cattle. Maternal serum triglycerides at day 190 of gestation were decreased (P<0.05) in association with maternal NR. Foetal serum triglycerides at day 190 of gestation were increased (P<0.05) in response to maternal NR during early gestation but decreased by NR in mid gestation compared with CON foetuses. The data show that maternal nutrient restriction during early or mid-gestation cause’s asymmetrical foetal growth restriction, regardless if the restriction is preceded or followed by a period of non-restriction.

Keywords

bos taurusfoetal growthfoetal programmingmaternal metabolitesmaternal undernutrition
Type
Research Article
Information
animal , Volume 12 , Issue 2 , February 2018 , pp. 312 - 321
Copyright
© The Animal Consortium 2017 

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