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Effects of guanidinoacetic acid supplementation on growth performance, nutrient digestion, rumen fermentation and blood metabolites in Angus bulls

Published online by Cambridge University Press:  25 June 2020

S. Y. Li ,
C. Wang ,
Z. Z. Wu ,
Q. Liu Open the ORCID record for Q. Liu [Opens in a new window] ,
G. Guo ,
W. J. Huo ,
J. Zhang ,
L. Chen ,
Y. L. Zhang  and
C. X. Pei
...Show all authors
S. Y. Li
Affiliation:
College of Animal Science and Veterinary Medicine, Shanxi Agricultural University, Taigu, 030801, Shanxi Province, P. R. China
C. Wang
Affiliation:
College of Animal Science and Veterinary Medicine, Shanxi Agricultural University, Taigu, 030801, Shanxi Province, P. R. China
Z. Z. Wu
Affiliation:
College of Animal Science and Veterinary Medicine, Shanxi Agricultural University, Taigu, 030801, Shanxi Province, P. R. China
Q. Liu*
Affiliation:
College of Animal Science and Veterinary Medicine, Shanxi Agricultural University, Taigu, 030801, Shanxi Province, P. R. China
G. Guo
Affiliation:
College of Animal Science and Veterinary Medicine, Shanxi Agricultural University, Taigu, 030801, Shanxi Province, P. R. China
W. J. Huo
Affiliation:
College of Animal Science and Veterinary Medicine, Shanxi Agricultural University, Taigu, 030801, Shanxi Province, P. R. China
J. Zhang
Affiliation:
College of Animal Science and Veterinary Medicine, Shanxi Agricultural University, Taigu, 030801, Shanxi Province, P. R. China
L. Chen
Affiliation:
College of Animal Science and Veterinary Medicine, Shanxi Agricultural University, Taigu, 030801, Shanxi Province, P. R. China
Y. L. Zhang
Affiliation:
College of Animal Science and Veterinary Medicine, Shanxi Agricultural University, Taigu, 030801, Shanxi Province, P. R. China
C. X. Pei
Affiliation:
College of Animal Science and Veterinary Medicine, Shanxi Agricultural University, Taigu, 030801, Shanxi Province, P. R. China
S. L. Zhang
Affiliation:
College of Animal Science and Veterinary Medicine, Shanxi Agricultural University, Taigu, 030801, Shanxi Province, P. R. China
*
†E-mail: [email protected]
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Abstract

Guanidinoacetic acid (GAA) can improve the growth performance of bulls. This study investigated the influences of GAA addition on growth, nutrient digestion, ruminal fermentation and serum metabolites in bulls. Forty-eight Angus bulls were randomly allocated to experimental treatments, that is, control, low-GAA (LGAA), medium-GAA (MGAA) and high-GAA (HGAA), with GAA supplementation at 0, 0.3, 0.6 and 0.9 g/kg DM, respectively. Bulls were fed a basal diet containing 500 g/kg DM concentrate and 500 g/kg DM roughage. The experimental period was 104 days, with 14 days for adaptation and 90 days for data collection. Bulls in the MGAA and HGAA groups had higher DM intake and average daily gain than bulls in the LGAA and control groups. The feed conversion ratio was lowest in MGAA and highest in the control. Bulls receiving 0.9 g/kg DM GAA addition had higher digestibility of DM, organic matter, NDF and ADF than bulls in other groups. The digestibility of CP was higher for HGAA than for LGAA and control. The ruminal pH was lower for MGAA, and the total volatile fatty acid concentration was greater for MGAA and HGAA than for the control. The acetate proportion and acetate-to-propionate ratio were lower for MGAA than for LGAA and control. The propionate proportion was higher for MGAA than for control. Bulls receiving GAA addition showed decreased ruminal ammonia N. Bulls in MGAA and HGAA had higher cellobiase, pectinase and protease activities and Butyrivibrio fibrisolvens, Prevotella ruminicola and Ruminobacter amylophilus populations than bulls in LGAA and control. However, the total protozoan population was lower for MGAA and HGAA than for LGAA and control. The total bacterial and Ruminococcus flavefaciens populations increased with GAA addition. The blood level of creatine was higher for HGAA, and the activity of l-arginine glycine amidine transferase was lower for MGAA and HGAA, than for control. The blood activity of guanidine acetate N-methyltransferase and the level of folate decreased in the GAA addition groups. The results indicated that dietary addition of 0.6 or 0.9 g/kg DM GAA improved growth performance, nutrient digestion and ruminal fermentation in bulls.

Keywords

guanidinoacetateweight gainnutrient digestibilityrumen microflorablood indicators
Type
Research Article
Information
animal , Volume 14 , Issue 12 , December 2020 , pp. 2535 - 2542
Copyright
© The Author(s), 2020. Published by Cambridge University Press on behalf of The Animal Consortium

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