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Effects of alternative feed additives to medicinal zinc oxide on productivity, diarrhoea incidence and gut development in weaned piglets

Published online by Cambridge University Press:  26 February 2020

G. D. Satessa ,
N. J. Kjeldsen ,
M. Mansouryar ,
H. H. Hansen ,
J. K. Bache  and
M. O. Nielsen
G. D. Satessa
Affiliation:
Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Grønnegårdsvej 3, FrederiksbergC 1870, Denmark
N. J. Kjeldsen
Affiliation:
Livestock Innovation, SEGES, Axeltorv 3, CopenhagenV 1609, Denmark
M. Mansouryar
Affiliation:
Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Grønnegårdsvej 3, FrederiksbergC 1870, Denmark
H. H. Hansen
Affiliation:
Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Grønnegårdsvej 3, FrederiksbergC 1870, Denmark
J. K. Bache
Affiliation:
Livestock Innovation, SEGES, Axeltorv 3, CopenhagenV 1609, Denmark
M. O. Nielsen*
Affiliation:
Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Grønnegårdsvej 3, FrederiksbergC 1870, Denmark Department of Animal Science, Faculty of Technology, Aarhus University, Blichers Allé 20, Tjele8830, Denmark
*
†E-mail: [email protected]
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Abstract

The use of medicinal zinc oxide (ZnO) must be phased out by 2022, thus prompting an urgent need for alternative strategies to prevent diarrhoea in weaner piglets. The objectives of this study were to assess the impact on weaner piglet performance, diarrhoea incidence and gut development, when (1) dietary ZnO supplementation was substituted by alternative commercial products based on macroalgae, specific probiotics or synbiotics, or (2) dietary ZnO inclusion was reduced from 2500 to 1500 ppm. A total of 4680 DLY piglets (DanBred, Herlev, Denmark), weaned around 35 days of age, were randomly assigned according to sex and BW to six different dietary treatment groups. A basal diet was supplemented with no ZnO (NC = negative control), 2500 ppm ZnO (PC = positive control), 1500 ppm ZnO (RDZ = reduced dose of ZnO) or commercial macroalgae (OceanFeed™ Swine = OFS), probiotic Miya-Gold or synbiotic GærPlus products. The piglets entered and exited the weaner unit at ~7.0 and 30 kg BW, respectively. In-feed ZnO was provided the first 10 days post-weaning, while the alternative supplements were fed throughout the weaner period. As expected, the average daily feed intake, average daily weight gain (ADG), feed conversion ratio (FCR) and diarrhoea incidence were improved in the PC compared to NC group (P < 0.05) during phase 1 consistent with improved indices of villi development observed in subgroups of piglets sacrificed 11 days post-weaning. Reduction of ZnO to 1500 ppm lowered ADG (P < 0.05) and slightly increased incidence of diarrhoea during the first 10 days after weaning (but not later) without affecting FCR. None of the three alternative dietary additives, including a 10-fold increased dose of GærPlus than recommended, improved piglet performance, gut health and gut development above that of NC piglets. The OFS piglets sacrificed 11 days after weaning had significantly lower weights of hindgut tissue and contents compared to the PC group, consistent with antimicrobial activity of the product, which was detected from anaerobic in vitro fermentation. In conclusion, dietary ZnO supplementation during the first 10 days post-weaning may be reduced from 2500 to 1500 ppm without major negative implications for weaner piglet performance and health in herds under a high management level. However, none of the alternative dietary supplements were able to improve piglet performance or gut health, when ZnO was omitted from the diet.

Keywords

probioticmacroalgaeyeastvilli developmenthindgut development
Type
Research Article
Information
animal , Volume 14 , Issue 8 , August 2020 , pp. 1638 - 1646
Copyright
© The Animal Consortium 2020

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References

Awad, WA, Ghareeb, K, Abdel-Raheem, S and Böhm, J 2009. Effects of dietary inclusion of probiotic and synbiotic on growth performance, organ weights, and intestinal histomorphology of broiler chickens. Poultry Science 88, 49–56.CrossRefGoogle ScholarPubMed
Bedford, A and Gong, J 2018. Implications of butyrate and its derivatives for gut health and animal production. Animal Nutrition 4, 51–59.CrossRefGoogle ScholarPubMed
Bednorz, C, Oelgeschläger, K, Kinnemann, B, Hartmann, S, Neumann, K, Pieper, R, Bethe, A, Semmler, T, Tedin, K, Schierack, P and Wieler, LH 2013. The broader context of antibiotic resistance: zinc feed supplementation of piglets increases the proportion of multi-resistant Escherichia coli in vivo. International Journal of Medical Microbiology 303, 396–403.CrossRefGoogle Scholar
Campbell, JM, Crenshaw, JD and Polo, J 2013. The biological stress of early weaned piglets. Domestic Animal Endocrinology 19, 63–74.Google Scholar
Dębski, B 2016. Supplementation of pigs diet with zinc and copper as alternative to conventional antimicrobials. Polish Journal of Veterinary Sciences 19, 917–924.CrossRefGoogle ScholarPubMed
EFSA 2011. Scientific Opinion on Miya-Gold® (Clostridium butyricum) as a feed additive for weaned piglets, minor weaned porcine species and minor avian species. EFSA Journal 9, 1951.CrossRefGoogle Scholar
Gardiner, GE, Campbellc, AJ, O’Dohertyd, JV, Pierce, E, Lynchc, PB, Leonardd, FC, Stantona, C, Rossa, RP and Lawlor, PG 2008. Effect of Ascophyllum nodosum extract on growth performance, digestibility, carcass characteristics and selected intestinal microflora populations of grower-finisher pigs. Animal Feed Science and Technology 141, 259–273.CrossRefGoogle Scholar
Hansen, HH, Storm, ID and Sell, AM 2012. Effect of biochar on in vitro rumen methane production. Acta Agriculturae Scandinavica, Section A–Animal Science 62, 305–309.CrossRefGoogle Scholar
Hill, GM, Mahan, DC, Carter, SD, Cromwell, GL, Ewan, RC, Harrold, RL, Lewis, AJ, Miller, PS, Shurson, GC and Veum, TL 2001. Effect of pharmacological concentrations of zinc oxide with or without the inclusion of an antibacterial agent on nursery pig performance. Journal of Animal Science 79, 934–41.CrossRefGoogle ScholarPubMed
Jensen, J, Larsen, MM and Bak, J 2016. National monitoring study in Denmark finds increased and critical levels of copper and zinc in arable soils fertilized with pig slurry. Environmental Pollution 214, 334–340.CrossRefGoogle ScholarPubMed
Kantas, D, Papatsiros, VG, Tassis, PD, Giavasis, I, Bouki, P and Tzika, ED 2015. A feed additive containing Bacillus toyonensis (Toyocerin®) protects against enteric pathogens in postweaning piglets. Journal of Applied Microbiology 118, 727–738.CrossRefGoogle ScholarPubMed
Lacorn, M, Goerke, M and Claus, R 2010. Inulin-coated butyrate increases ileal MCT1 expression and affects mucosal morphology in the porcine ileum by reduced apoptosis. Journal of Animal Physiology and Animal Nutrition 94, 670–676.CrossRefGoogle ScholarPubMed
Lei, XJ and Kim, IH 2018. Low dose of coated zinc oxide is as effective as pharmacological zinc oxide in promoting growth performance, reducing fecal scores, and improving nutrient digestibility and intestinal morphology in weaned pigs. Animal Feed Science and Technology 245, 117–125.CrossRefGoogle Scholar
Liu, Y, Espinosa, CD, Abelilla, JJ, Casas, GA, Lagos, LV, Lee, SA, Kwon, WB, Mathai, JK, Navarro, DM, Jaworski, NW and Stein, HH 2018. Non-antibiotic feed additives in diets for pigs: a review. Animal Nutrition 4, 113–125.CrossRefGoogle ScholarPubMed
Makkar, HP, Tran, G, Heuzé, V, Giger-Reverdin, S, Lessire, M, Lebas, F and Ankers, P 2016. Seaweeds for livestock diets: a review. Animal Feed Science and Technology 212, 1–7.CrossRefGoogle Scholar
Mavromichalis, I, Webel, DM, Parr, EN and Baker, DH 2001. Growth-promoting efficacy of pharmacological doses of tetrabasic zinc chloride in diets for nursery pigs. Canadian Journal of Animal Science 81, 387–391.CrossRefGoogle Scholar
McDonnell, P, Figat, S and O’doherty, JV 2010. The effect of dietary laminarin and fucoidan in the diet of the weanling piglet on performance, selected faecal microbial populations and volatile fatty acid concentrations. Animal 4, 579–585.CrossRefGoogle ScholarPubMed
Michiels, J, Skrivanova, E, Missotten, J, Ovyn, A, Mrazek, J, De Smet, S and Dierick, N 2012. Intact brown seaweed (Ascophyllum nodosum) in diets of weaned piglets: effects on performance, gut bacteria and morphology and plasma oxidative status. Journal of Animal Physiology and Animal Nutrition 96, 1101–1111.CrossRefGoogle ScholarPubMed
Poulsen, HD 1995. Zinc oxide for weanling piglets. Acta Agriculturae Scandinavica A–Animal Sciences 45, 159–167.Google Scholar
Poulsen, HD 1998. Zinc and copper as feed additives, growth factors or unwanted environmental factors. Journal of Animal and Feed Sciences 7, 135–142.CrossRefGoogle Scholar
R Core Team 2017. R: A Language and Environment for Statistical Computing. R Foundation for Statistical Computing, Vienna, Austria.Google Scholar
Roselli, M, Finamore, A, Britti, MS, Bosi, P, Oswald, I and Mengheru, E 2005. Alternatives to in-feed antibiotics in pigs: evaluation of probiotics, zinc or organic acids as protective agents for the intestinal mucosa. A comparison of in vitro and in vivo results. Animal Research 54, 203–218.CrossRefGoogle Scholar
Roselli, M, Pieper, R, Rogel-Gaillard, C, de Vries, H, Bailey, M, Smidt, H and Lauridsen, C 2017. Immunomodulating effects of probiotics for microbiota modulation, gut health and disease resistance in pigs. Animal Feed Science and Technology 233, 104–119.CrossRefGoogle Scholar
Shen, J, Chen, Y, Wang, Z, Zhou, A, He, M, Mao, L, Zou, H, Peng, Q, Xue, B, Wang, L and Zhang, X 2014. Coated zinc oxide improves intestinal immunity function and regulates microbiota composition in weaned piglets. British Journal of Nutrition 111, 2123–2134.CrossRefGoogle ScholarPubMed
Slifierz, MJ, Friendship, R and Weese, JS 2015. Zinc oxide therapy increases prevalence and persistence of methicillin-resistant staphylococcus aureus in pigs: a randomized controlled trial. Zoonoses and Public Health 62, 301–308.CrossRefGoogle ScholarPubMed
Øverland, M, Mydland, LT and Skrede, A 2018. Marine macroalgae as a source of protein and bioactive compounds in feed for monogastric animals. Journal of the Science of Food and Agriculture 99, 13–24.CrossRefGoogle Scholar
Wang, X, Farnell, YZ, Peebles, ED, Kiess, AS, Wamsley, KG and Zhai, W 2016. Effects of prebiotics, probiotics, and their combination on growth performance, small intestine morphology, and resident Lactobacillus of male broilers. Poultry Science 95, 1332–1340.CrossRefGoogle ScholarPubMed
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