Hostname: page-component-586b7cd67f-t7czq Total loading time: 0 Render date: 2024-11-30T21:15:08.385Z Has data issue: false hasContentIssue false
  • English
  • Français

Effects of a chronic stress treatment on vaccinal response in lambs

Published online by Cambridge University Press:  07 November 2016

A. Destrez ,
A. Boissy ,
L. Guilloteau ,
S. Andanson ,
A. Souriau ,
K. Laroucau ,
E. Chaillou  and
V. Deiss
A. Destrez*
Affiliation:
AgroSup Dijon/INRA, UMR 1273 Métafort, 21079 Dijon, France
A. Boissy
Affiliation:
INRA, UMRH 1213 Herbivores, 63122 Saint-Genès-Champanelle, France
L. Guilloteau
Affiliation:
INRA, UR 1282 Unité d’Infectiologie et Santé Publique, 37380 Nouzilly, France
S. Andanson
Affiliation:
INRA, UMRH 1213 Herbivores, 63122 Saint-Genès-Champanelle, France
A. Souriau
Affiliation:
INRA, UR 1282 Unité d’Infectiologie et Santé Publique, 37380 Nouzilly, France
K. Laroucau
Affiliation:
Laboratoire de Santé animale, Unité Zoonoses Bactériennes, ANSES, 94701 Maisons-Alfort Cedex, France
E. Chaillou
Affiliation:
INRA, UMR 85 Physiologie de la Reproduction et des Comportements, 37380 Nouzilly, France
V. Deiss
Affiliation:
INRA, UMRH 1213 Herbivores, 63122 Saint-Genès-Champanelle, France
*
† E-mail: [email protected]
Get access

Abstract

Farming systems can expose animals to chronic mild stress which is known to induce negative affective state. Affective state in animals, as in humans, can be assessed through behavioral cues. This study aimed to describe the effect of a chronic mild stress, known to induce a negative affective state, on sheep health through their response to vaccination. The study used 15 lambs subjected to a model of chronic mild stress for 15 weeks and 15 lambs reared under conventional farming as a control group. After 7 weeks of stressful treatment, the lambs were individually exposed to a judgment bias test to assess a putative stress-induced ‘pessimism.’ After 15 weeks of stressful treatment, antibody immune response was measured after an injection of a live vaccine challenge (Chlamydia abortus attenuated vaccine strain 1B). Stressed lambs displayed a pessimistic-like perception in the judgment bias test, revealing a negative affective state. Stressed and control animals showed different immunological reactions to vaccine challenge: stressed sheep had lower hemoglobin concentrations and higher platelet, granulocyte and acute-phase protein concentrations. Antibody response induced by the vaccine strain was not different between stressed and control sheep. Our results suggest that negative affective state induced by chronic stress treatment may induce a stronger inflammatory response to vaccine challenge in sheep. Improvement of animal health may be achieved through consideration of stressors that may affect the emotional and immunological state of sheep.

Keywords

chronic stressvaccinationnegative affective stateovinehealth
Type
Research Article
Information
animal , Volume 11 , Issue 5 , May 2017 , pp. 872 - 880
Copyright
© The Animal Consortium 2016 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Adams, DC and Anthony, CD 1996. Using randomization techniques to analyse behavioural data. Animal Behaviour 51, 733–738.Google Scholar
Ader, R and Cohen, N 1993. Psychoneuroimmunology: conditioning and stress. Annual Review of Psychology 44, 53–85.CrossRefGoogle ScholarPubMed
Anisman, H and Matheson, K 2005. Stress, depression, and anhedonia: caveats concerning animal models. Neuroscience and Biobehavioral Reviews 29, 525–546.Google Scholar
Boissy, A and Bouissou, MF 1994. Effects of androgen treatment on behavioral and physiological-responses of heifers to fear-eliciting situation. Hormones and Behavior 28, 66–83.CrossRefGoogle Scholar
Coppinger, TR, Minton, JE, Reddy, PG and Blecha, F 1991. Repeated restraint and isolation stress in lambs increases pituitary-adrenal secretions and reduces cell-mediated immunity. Journal of Animal Science 69, 2808–2814.Google Scholar
Cray, C, Zaias, J and Altman, NH 2009. Acute phase response in animals: a review. Comparative Medicine 59, 517–526.Google Scholar
Destrez, A, Deiss, V, Leterrier, C, Boivin, X and Boissy, A 2013a. Long-term exposure to unpredictable and uncontrollable aversive events alters fearfulness in sheep. Animal 7, 476–484.Google Scholar
Destrez, A, Deiss, V, Leterrier, C, Calandreau, L and Boissy, A 2014. Repeated exposure to positive events induces optimistic-like judgment and enhances fearfulness in chronically stressed sheep. Applied Animal Behaviour Science 154, 30–38.Google Scholar
Destrez, A, Deiss, V, Lévy, F, Calandreau, L, Lee, C, Chaillou-Sagon, E and Boissy, A 2013b. Chronic stress induces pessimistic-like judgment and learning deficits in sheep. Applied Animal Behaviour Science 148, 28–36.Google Scholar
Dhabhar, F 2014. Effects of stress on immune function: the good, the bad, and the beautiful. Immunologic Research 58, 193–210.Google Scholar
Doyle, RE, Fisher, AD, Hinch, GN, Boissy, A and Lee, C 2009. Release from restraint generates a positive judgement bias in sheep. Applied Animal Behaviour Science 122, 28–34.Google Scholar
Eckersall, PD and Bell, R 2010. Acute phase proteins: biomarkers of infection and inflammation in veterinary medicine. The Veterinary Journal 185, 23–27.Google Scholar
Eckersall, PD, Lawson, F, Bence, L, Waterston, M, Lang, T, Donachie, W and Fontaine, M 2007. Acute phase protein response in an experimental model of ovine caseous lymphadenitis. BMC Veterinary Research 3, 35.Google Scholar
Eckersall, PD, Lawson, F, Kyle, C, Waterston, M, Bence, L, Stear, M and Rhind, S 2008. Maternal undernutrition and the ovine acute phase response to vaccination. BMC Veterinary Research 4, 1.Google Scholar
Ehricht, R, Slickers, P, Goellner, S, Hotzel, H and Sachse, K 2006. Optimized DNA microarray assay allows detection and genotyping of single PCR-amplifiable target copies. Molecular and Cellular Probes 20, 60–63.Google Scholar
Glaser, R, Sheridan, J, Malarkey, WB, MacCallum, RC and Kiecolt-Glaser, JK 2000. Chronic stress modulates the immune response to a pneumococcal pneumonia vaccine. Psychosomatic Medicine 62, 804–807.Google Scholar
Harding, EJ, Paul, ES and Mendl, M 2004. Animal behavior – cognitive bias and affective state. Nature 427, 312–312.CrossRefGoogle ScholarPubMed
Kim, M-H, Yang, J-Y, Upadhaya, SD, Lee, H-J, Yun, C-H and Ha, JK 2011. The stress of weaning influences serum levels of acute-phase proteins, iron-binding proteins, inflammatory cytokines, cortisol, and leukocyte subsets in Holstein calves. Journal of Veterinary Science 12, 151–157.Google Scholar
Korte, SM 2001. Corticosteroids in relation to fear, anxiety and psychopathology. Neuroscience & Biobehavioral Reviews 25, 117–142.Google Scholar
Ladewig, J and Smidt, D 1989. Behavior, episodic secretion of cortisol, and adrenocortical reactivity in bulls subjected to tethering. Hormones and Behavior 23, 344–360.Google Scholar
Leonard, BE and Song, C 1996. Stress and the immune system in the etiology of anxiety and depression. Pharmacology Biochemistry and Behavior 54, 299–303.CrossRefGoogle ScholarPubMed
Maier, SF, Silbert, LH, Woodmansee, WW and Desan, PH 1990. Adinazolam both prevents and reverses the long-term reduction of daily activity produced by inescapable shock. Pharmacology Biochemistry and Behavior 36, 767–773.Google Scholar
Nezam, FS, Hosseini, SM, Kheiri, MT, Abdoli, A, Memarnejadian, A, Shenagari, M, Gholami, S, Sohani, H, Rahmatollahi, H and Jamali, A 2015. Suppressive effects of chronic stress on influenza virus protection after vaccination with plasmid DNA-encoded nucleoprotein. Neuroimmunomodulation 22, 322–327.Google Scholar
Oishi, K, Nishio, N, Konishi, K, Shimokawa, M, Okuda, T, Kuriyama, T and Machida, K 2003. Differential effects of physical and psychological stressors on immune functions of rats. Stress 6, 33–40.CrossRefGoogle ScholarPubMed
Pantchev, A, Sting, R, Bauerfeind, R, Tyczka, J and Sachse, K 2009. New real-time PCR tests for species-specific detection of Chlamydophila psittaci and Chlamydophila abortus from tissue samples. Veterinary Journal 181, 145–150.Google Scholar
Paul, ES, Harding, EJ and Mendl, M 2005. Measuring emotional processes in animals: the utility of a cognitive approach. Neuroscience & Biobehavioral Reviews 29, 469–491.Google Scholar
Petersen, HH, Nielsen, JP and Heegaard, PMH 2004. Application of acute phase protein measurements in veterinary clinical chemistry. Veterinary Research 35, 163–187.CrossRefGoogle ScholarPubMed
Raison, CL, Capuron, L and Miller, AH 2006. Cytokines sing the blues: inflammation and the pathogenesis of depression. Trends in Immunology 27, 24–31.Google Scholar
Ribas, VR, Martins, HAdL, Viana, MT, Fraga, SdN, Carneiro, SMdO, Galvão, BHA, Bezerra, AA, Castro, CMMBd, Sougey, EB and Castro, RMd 2011. Hematological and immunological effects of stress of air traffic controllers in northeastern Brazil. Revista Brasileira de Hematologia e Hemoterapia 33, 195–201.Google Scholar
Rodolakis, A and Souriau, A 1983. Response of ewes to temperature-sensitive mutants of Chlamydia psittaci (var ovis) obtained by NTG mutagenesis. Annales de Recherches Veterinaires 14, 155–161.Google Scholar
Rushen, J 1991. Problems associated with the interpretation of physiological data in the assessment of animal welfare. Applied Animal Behaviour Science 28, 381–386.Google Scholar
Rushen, J, Taylor, AA and de Passille, AM 1999. Domestic animals’ fear of humans and its effect on their welfare. Applied Animal Behaviour Science 65, 285–303.Google Scholar
Veissier, I and Leneindre, P 1988. Cortisol responses to physical and pharmacological stimuli in heifers. Reproduction Nutrition Development 28, 553–562.Google Scholar
Veissier, I, Boissy, A, dePassille, AM, Rushen, J, van Reenen, CG, Roussel, S, Andnason, S and Pradel, P 2001. Calves’ responses to repeated social regrouping and relocation. Journal of Animal Science 79, 2580–2593.Google Scholar
von Borell, E 1995. Neuroendocrine integration of stress and significance of stress for the performance of farm animals. Applied Animal Behaviour Science 44, 219–227.Google Scholar