Hostname: page-component-586b7cd67f-tf8b9 Total loading time: 0 Render date: 2024-11-24T02:30:55.605Z Has data issue: false hasContentIssue false

The effect of selenium sources and supplementation on neutrophil functions in dairy cows

Published online by Cambridge University Press:  01 July 2009

A. E. Ibeagha
Affiliation:
Department of Animal Science, McGill University, 21111 Lakeshore Road, Sainte-Anne-de-Bellevue, Quebec H9X 3V9, Canada
E. M. Ibeagha-Awemu
Affiliation:
Department of Animal Science, McGill University, 21111 Lakeshore Road, Sainte-Anne-de-Bellevue, Quebec H9X 3V9, Canada
J. Mehrzad
Affiliation:
Sections Immunology and Biotechnology, Department of Pathobiology, Faculty of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, Iran
B. Baurhoo
Affiliation:
Department of Animal Science, McGill University, 21111 Lakeshore Road, Sainte-Anne-de-Bellevue, Quebec H9X 3V9, Canada
P. Kgwatalala
Affiliation:
Department of Animal Science, McGill University, 21111 Lakeshore Road, Sainte-Anne-de-Bellevue, Quebec H9X 3V9, Canada
X. Zhao*
Affiliation:
Department of Animal Science, McGill University, 21111 Lakeshore Road, Sainte-Anne-de-Bellevue, Quebec H9X 3V9, Canada
Get access

Abstract

Selenium (Se), an essential micronutrient, is believed to enhance neutrophil functions. This study aimed to compare the effects of supplemented organic (Sel-Plex®) and inorganic (sodium selenite) Se on neutrophil functions in high-producing dairy cows, during the periparturient period. Twenty-five Holstein cows were randomly allocated to five dietary treatments as follows: control diet (basal diet without Se supplementation), IN 0.3 (basal diet supplemented with inorganic Se at 0.3 mg/kg dry matter (DM)), IN 0.5 (inorganic Se at 0.5 mg/kg DM), OR 0.3 (organic Se at 0.3 mg/kg DM) and OR 0.5 (organic Se at 0.5 mg/kg DM). Some evaluated parameters included neutrophil functions and plasma Se concentrations in cows and plasma Se concentrations in calves. Neutrophil phagocytosis did not significantly differ among the five groups. However, organic Se supplementation significantly increased (P < 0.01) the respiratory burst of neutrophils when compared to cows fed IN 0.3 and the control diet. In comparison to inorganic Se, neutrophil apoptosis was decreased (P < 0.01) when cows were fed organic Se or the control diets. These effects of organic Se on respiratory burst activities and apoptosis of neutrophils were in a dose-dependent manner. Calf plasma Se concentrations were higher (P < 0.05) when cows were fed OR 0.5 and IN 0.5.

Type
Full Paper
Copyright
Copyright © The Animal Consortium 2009

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Aziz, E, Klesius, PH 1986. Effect of selenium deficiency on caprine polymorphonuclear leucocyte production of leucotriene B4 and its neutrophil chemotactic activity. American Journal of Veterinary Research 47, 426428.Google Scholar
Boyne, R, Arthur, JR 1986. The response of selenium deficient mice to Candida albicans infection. The Journal of Nutrition 116, 816822.CrossRefGoogle ScholarPubMed
Bruzelius, K, Hoac, T, Sundler, R, Önning, G, Äkesson, B 2007. Occurrence of selenoprotein enzyme activities and mRNA in bovine mammary tissue. Journal of Dairy Science 90, 918927.Google Scholar
Grasso, P, Scholz, RW, Erskine, RJ, Eberhart, RJ 1990. Phagocytosis, bacterial activity and oxidative metabolism of mammary neutrophils from dairy cows fed selenium-adequate and selenium-deficient diets. American Journal of Veterinary Research 51, 269275.CrossRefGoogle Scholar
Gunter, SA, Beck, PA, Phillips, JM 2003. Effects of supplementary selenium source on the performance and blood measurements in beef cows and their calves. Journal of Animal Science 81, 856864.Google Scholar
Gyang, EO, Stevens, JB, Olsen, WG, Tsitsamis, SD, Usenik, EA 1984. Effects of selenium–vitamin E injection on the bovine polymorphonucleated leukocytes phagocytosis and killing of Staphylococcus aureus. American Journal of Veterinary Research 45, 175179.Google ScholarPubMed
Hawkes, WC, Kutnink, MA 1996. High-performance liquid chromatographic-fluorescence determination of traces of selenium in biological materials. Analytical Biochemistry 241, 206211.CrossRefGoogle ScholarPubMed
Hogan, JS, Smith, KL, Weiss, WP, Todhunter, DA, Schockey, WL 1990. Relationships among vitamin E, selenium, and bovine blood neutrophils. Journal of Dairy Science 73, 23722378.CrossRefGoogle ScholarPubMed
Ibeagha, AE, Ibeagha-Awemu, EM, Mehrzad, J, Zhao, X 2007. Selenium, immune functions and health of dairy cattle. In Nutritional biotechnology in feed and food industries (ed. TP Lyons, KA Jacques and JM Hower), pp. 289303. Nottingham University Press, Nottingham, UK.Google Scholar
Jukola, E, Hakkarainen, J, Saloniemi, H, Sankari, S 1996. Blood selenium, vitamin E, vitamin A, and ß-carotene concentrations and udder health, fertility treatments, and fertility. Journal of Dairy Science 79, 838845.Google Scholar
Juniper, DT, Phipps, RH, Jones, AK, Bertin, G 2006. Selenium supplementation of lactating dairy cows: effect of selenium concentration on blood, milk, urine and feces. Journal of Dairy Science 89, 35443551.Google Scholar
Kampen, AH, Tollersrud, T, Larsen, S, Roth, JA, Frank, DE, Lund, A 2004. Repeatability of flow cytometric and classical measurement of phagocytosis and respiratory burst in bovine polymorphonuclear leukocytes. Veterinary Immunology and Immunopathology 97, 105114.CrossRefGoogle ScholarPubMed
Knowles, SO, Grace, ND, Wurms, K, Lee, J 1999. Significance of amount and form of dietary selenium on blood, milk and casein selenium concentrations in grazing cows. Journal of Dairy Science 82, 429437.Google Scholar
Kommisrud, E, Østeras, O, Vatn, T 2005. Blood selenium associated with health and fertility in Norwegian dairy herds. Acta Veterinaria Scandinavia 46, 229240.Google Scholar
Koopman, G, Reutelingsperger, CM, Kuitten, GAM, Keehnen, RMJ, Pals, ST, van Oers, MHJ 1994. Annexin V for flow cytometric detection of phosphatidylserine expression on B cells undergoing apoptosis. Blood 84, 14151420.Google Scholar
Larsen, HJS 1993. Relations between selenium and immunity. Norwegian Journal of Agricultural Science (suppl. 11), 105119.Google Scholar
Malbe, M, Klaassen, M, Fang, W, Myllys, V, Vikerpuur, M, Nyholm, K, Sankari, S, Suoranta, K, Sandholm, M 1995. Comparison of selenite and selenium yeast feed supplements on Se-incorporation, mastitis and leukocyte function in Se-deficient dairy cows. Zentralblatt für Veterinärmedizin A 42, 111121.Google Scholar
Malbe, M, Klaassen, E, Kaartinen, L, Attila, M, Atroshi, F 2003. Effects of oral selenium supplementation on mastitis markers and pathogens in Estonian cows. Veterinary Therapeutics 4, 145154.Google ScholarPubMed
Malbe, M, Attila, M, Atroshi, F 2006. Possible involvement of selenium in Staphylococcus aureus inhibition in cow’s whey. Journal of Animal Physiology and Animal Nutrition 90, 159164.Google Scholar
Mehrzad, J, Duchateau, L, Pyorala, S, Burvenich, C 2002. Blood and milk neutrophil chemiluminescence and viability in primiparous and pluriparous dairy cows during late pregnancy, around parturition and early lactation. Journal of Dairy Science 85, 32683276.CrossRefGoogle ScholarPubMed
Mehrzad, J, Duchateau, L, Burvenich, C 2004. Viability of milk neutrophils and severity of bovine coliform mastitis. Journal of Dairy Science 87, 41504162.Google Scholar
Musik, I, Koziol-Montewka, M, Tos-Luty, S, Pasternak, K, Latuszynska, J, Tokarska, M, Kielczykowska, M 1999. Immunomodulatory effect of selenosemicarbazides and selenium inorganic compounds, distribution in organs after selenium supplementation. Biometals 12, 369374.CrossRefGoogle ScholarPubMed
Ndiweni, N, Finch, JM 1995. Effects of in vitro supplementation of bovine mammary gland macrophages and peripheral blood lymphocytes with α-tocopherol and sodium selenite: implications for udder defences. Veterinary Immunology and Immunopathology 47, 111121.CrossRefGoogle ScholarPubMed
Ortman, K, Pehrson, B 1999. Effect of selenate as a feed supplement to dairy cows in comparison to selenite and selenium yeast. Journal of Animal Science 77, 33653370.CrossRefGoogle ScholarPubMed
Pehrson, B, Ortman, K, Madjid, N, Trafikowska, U 1999. The influence of dietary selenium as selenium yeast or sodium selenite on the concentration of selenium in the milk of suckler cows and on the selenium status of their calves. Journal of Animal Science 77, 33713376.Google Scholar
Ranjan, R, Swarup, D, Naresh, R, Partra, RC 2005. Enhanced erythrocytic lipid peroxides and reduced plasma ascorbic acid, and alteration in blood trace elements level in dairy cow mastitis. Veterinary Research Communication 29, 2734.CrossRefGoogle Scholar
SAS Institute 2003. SAS user’s guide, version 9.1, 1st edition.SAS Institute Inc., Cary, NC, USA.Google Scholar
Sivertsen, T, Øvernes, G, Østerås, O, Nymoen, U, Lunder, T 2005. Plasma vitamin E and blood selenium concentrations in Norwegian dairy cows: regional differences and relations to feeding and health. Acta Veterinaria Scandinavia 46, 177191.CrossRefGoogle ScholarPubMed
Smits, E, Burvenich, C, Heyneman, R 1997. Simultaneous flow cytometric measurement of phagocytotic and oxidative burst activity of polymorphonuclear leukocytes in whole blood. Veterinary Immunology and Immunopathology 56, 259269.CrossRefGoogle Scholar
Spears, JW 2000. Micronutrients and immune function in cattle. Proceedings of the Nutrition Society 59, 587594.Google Scholar
Van Oostveldt, K, Dosogne, H, Burvenich, C, Paape, MJ, Brochez, V, Van den Eeckhout, E 1999. Flow cytometric procedure to detect apoptosis of bovine polymorphonuclear leukocytes in blood. Veterinary Immunology and Immunopathology 70, 125133.CrossRefGoogle ScholarPubMed
Van Oostveldt, K, Vangroenweghe, F, Dosogne, H, Burvenich, C 2001. Apoptosis and necrosis of blood and milk polymorphonuclear leukocytes in early and mid-lactating healthy cows. Veterinary Research 32, 617622.Google Scholar
Van Oostveldt, K, Vangroenweghe, F, Dosogne, H, Burvenich, C 2002. Effect of apoptosis on phagocytosis, respiratory burst and CD18 adhesion receptor expression on bovine neutrophils. Domestic Animal Endocrinology 22, 3750.CrossRefGoogle ScholarPubMed
Van Saun, RJ 1990. Rational approach to selenium supplementation essential. Feedstuffs 15, 1517.Google Scholar
Weiss, WP, Hogan, JS 2005. Effect of selenium source on selenium status, neutrophil function and response to intramammary endotoxin challenge of dairy cows. Journal of Dairy Science 88, 43664374.CrossRefGoogle ScholarPubMed
Weiss, WP, Hogan, JS, Smith, KL, Hoblet, KH 1990. Relationships among selenium, vitamin E, and mammary gland health in commercial dairy herds. Journal of Dairy Science 73, 381390.CrossRefGoogle ScholarPubMed
Yoon, I, McMillan, E 2006. Comparative effects of organic and inorganic selenium on selenium transfer from sows of nursing pigs. Journal of Animal Science 84, 17291733.Google Scholar