Hostname: page-component-586b7cd67f-g8jcs Total loading time: 0 Render date: 2024-11-30T20:13:48.907Z Has data issue: false hasContentIssue false
  • English
  • Français

Effect of litter size on prepartum metabolic and amino acidic profile in rabbit does

Published online by Cambridge University Press:  11 May 2020

A. Minuti Open the ORCID record for A. Minuti [Opens in a new window] ,
A. Gallo ,
V. Lopreiato ,
S. Bruschi ,
F. Piccioli-Cappelli ,
O. Uboldi  and
E. Trevisi
A. Minuti*
Affiliation:
Department of Animal Sciences, Food and Nutrition – DIANA, Faculty of Agriculture, Food and Environmental Science, Università Cattolica del Sacro Cuore, via Emilia Parmense 84, 29122Piacenza, Italy PRONUTRIGEN – Centro di Ricerca sulla Nutrigenomica e Proteomica, Università Cattolica del Sacro Cuore, via Emilia Parmense 84, 29122Piacenza, Italy
A. Gallo
Affiliation:
Department of Animal Sciences, Food and Nutrition – DIANA, Faculty of Agriculture, Food and Environmental Science, Università Cattolica del Sacro Cuore, via Emilia Parmense 84, 29122Piacenza, Italy
V. Lopreiato
Affiliation:
Department of Animal Sciences, Food and Nutrition – DIANA, Faculty of Agriculture, Food and Environmental Science, Università Cattolica del Sacro Cuore, via Emilia Parmense 84, 29122Piacenza, Italy
S. Bruschi
Affiliation:
Department of Animal Sciences, Food and Nutrition – DIANA, Faculty of Agriculture, Food and Environmental Science, Università Cattolica del Sacro Cuore, via Emilia Parmense 84, 29122Piacenza, Italy
F. Piccioli-Cappelli
Affiliation:
Department of Animal Sciences, Food and Nutrition – DIANA, Faculty of Agriculture, Food and Environmental Science, Università Cattolica del Sacro Cuore, via Emilia Parmense 84, 29122Piacenza, Italy
O. Uboldi
Affiliation:
Cargill s.r.l. Divisione Feed & Nutrition Società di Cargill inc., Via G. Ripamonti, 89, 20141Milano, Italy
E. Trevisi
Affiliation:
Department of Animal Sciences, Food and Nutrition – DIANA, Faculty of Agriculture, Food and Environmental Science, Università Cattolica del Sacro Cuore, via Emilia Parmense 84, 29122Piacenza, Italy PRONUTRIGEN – Centro di Ricerca sulla Nutrigenomica e Proteomica, Università Cattolica del Sacro Cuore, via Emilia Parmense 84, 29122Piacenza, Italy
*
†E-mail: [email protected]
Get access

Abstract

The use of modern prolific lines of rabbit does in intensive production systems leads to an increase in productivity but also causes a rise in several problems related to the does’ health status. Hence, the aim of this study was to investigate the effect of the litter size on the metabolic, inflammatory and plasma amino acid profile in rabbit does. The blood of 30 pregnant does was sampled on the 27th day of pregnancy. The does were retrospectively grouped according to the number of offspring into a high litter size group (HI, does with ≥ 12 kits; n = 16) and a low litter size group (LO, does with ≤ 11 kits; n = 14). Data were subjected to Pearson’s correlation analysis. Further, data were analysed in agreement to a completely randomized design in which the main tested effect was litter size. The linear or quadratic trends of litter size on parameters of interests were post hoc compared by using orthogonal contrasts. In addition, compared with the LO group, the HI group had lower levels of glucose (−5%; P < 0.01), zinc (−19%; P < 0.05), albumin (−6%; P < 0.05) and total cholesterol (−13%; P < 0.07), but the total bilirubin level was higher in the HI group (+14%; P < 0.05). Regarding the plasma amino acids, the HI group had lower concentrations of threonine (−15%), glycine (−16%), lysine (−16%) and tryptophan (−26%) and a higher level of glutamic acid (+43%; P < 0.05) compared with the LO group. The exclusively ketogenic amount of amino acids was lower (P < 0.06) in the HI (55.8 mg/100 ml) does compared with the LO does (56.8 mg/100 ml). These results show that a few days before delivery, rabbit does that gave birth to a higher number of offspring had a metabolic profile and an inflammatory status that was less favourable with respect to does who gave birth to a lower number of offspring. Moreover, the plasma amino acid profile points out that there was an enhanced catabolic condition in the rabbit does with a high number of gestated foetuses; it was likely related to the greater energy demand needed to support the pregnancy and an early inflammatory response.

Keywords

rabbit doegestationlitter sizeinflammometabolic conditionplasma amino acids
Type
Research Article
Information
animal , Volume 14 , Issue 10 , October 2020 , pp. 2109 - 2115
Copyright
© The Author(s), 2020. Published by Cambridge University Press on behalf of The Animal Consortium

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Block, WD and Hubbard, RW 1962. Amino acid content of rabbit urine and plasma. Archives of Biochemistry and Biophysics 96, 557–561.CrossRefGoogle ScholarPubMed
Calamari, L, Ferrari, A, Minuti, A and Trevisi, E 2016. Assessment of the main plasma parameters included in a metabolic profile of dairy cow based on Fourier Transform mid-infrared spectroscopy: preliminary results. BMC Veterinary Research 12, 4.CrossRefGoogle Scholar
Castellini, C, Dal Bosco, A, Arias-Álvarez, M, Lorenzo, PL, Cardinali, R and Rebollar, PG 2010. The main factors affecting the reproductive performance of rabbit does: a review. Animal Reproduction Science 122, 174–182.CrossRefGoogle ScholarPubMed
Gilbert, M, Hay, WW, Johnson, RL and Battaglia, FC 1984. Some aspects of maternal metabolism throughout pregnancy in the conscious rabbit. Pediatric Research 18, 854–859.CrossRefGoogle ScholarPubMed
Gruys, E, Toussaint, MJM, Niewold, TA and Koopmans, SJ 2005. Acute phase reaction and acute phase proteins. Journal of Zhejiang University Science B 6, 1045–1056.CrossRefGoogle ScholarPubMed
Jean-Blain, C and Durix, A 1985. Ketone body metabolism during pregnancy in the rabbit. Reproduction, Nutrition, Development 25, 545–554.CrossRefGoogle ScholarPubMed
Kurpad, AV 2006. The requirements of protein & amino acid during acute & chronic infections. The Indian Journal of Medical Research 124, 129–148.Google ScholarPubMed
Martínez-Paredes, E, Ródenas, L, Martínez-Vallespín, B, Cervera, C, Blas, E, Brecchia, G, Boiti, C and Pascual, JJ 2012. Effects of feeding programme on the performance and energy balance of nulliparous rabbit does. Animal 6, 1086–1095.CrossRefGoogle ScholarPubMed
Minuti, A, Bani, P, Piccioli-Cappelli, F, Uboldi, O, Bacciu, N and Trevisi, E 2015. Metabolic and biochemical changes in plasma of the periparturient rabbit does with different litter size. Animal 9, 614–621.CrossRefGoogle ScholarPubMed
Minuti, A, Calamari, L, Ferronato, G, Ferrari, A, Gachiuta, O, Bani, P and Trevisi, E 2019. Exploring Fourier transform mid-infra-red spectrometry to predict biochemical parameters in horse’s blood. Italian Journal of Animal Science 18, 1223–1230.CrossRefGoogle Scholar
Moore, S and Stein, WH 1954. A modified ninhydrin reagent for the photometric determination of amino acids and related compounds. The Journal of Biological Chemistry 211, 907–913.Google ScholarPubMed
Parigi-Bini, R, Xiccato, G and Cinetto, M 1990. No TitleEnergy and protein retention and partition in rabbit does during the first pregnancy. Cuni-Sciences 6, 19–31.Google Scholar
Pascual, JJ, Savietto, D, Cervera, C and Baselga, M 2013. Resources allocation in reproductive rabbit does: a review of feeding and genetic strategies for suitable performance. World Rabbit Science 21, 123–144.CrossRefGoogle Scholar
Rebollar, PG, Pereda, N, Schwarz, BF, Millán, P, Lorenzo, PL and Nicodemus, N 2011. Effect of feed restriction or feeding high-fibre diet during the rearing period on body composition, serum parameters and productive performance of rabbit does. Animal Feed Science and Technology 163, 67–76.CrossRefGoogle Scholar
Rosell, JM and de la Fuente, LF 2009. Culling and mortality in breeding rabbits. Preventive Veterinary Medicine 88, 120–127.CrossRefGoogle ScholarPubMed
Sánchez, JP, de la Fuente, LF and Rosell, JM 2012. Health and body condition of lactating females on rabbit farms. Journal of Animal Science 90, 2353–2361.CrossRefGoogle ScholarPubMed
Savietto, D, Marono, S, Martínez, I, Martínez-Paredes, E, Ródenas, L, Cervera, C and Pascual, JJ 2016. Patterns of body condition use and its impact on fertility. World Rabbit Science 24, 39.CrossRefGoogle Scholar
Trevisi, E and Minuti, A 2018. Assessment of the innate immune response in the periparturient cow. Research in Veterinary Science 116, 47–54.CrossRefGoogle ScholarPubMed
Xiccato, G 1996. Nutrition of lactating does. In Proceedings of the 6th world rabbit congress (ed. Lebas, F.), pp. 29–47. Association Française de Cuniculture, Lempdes, France, Toulouse, France.Google Scholar
Zhou, Z, Loor, JJ, Piccioli-Cappelli, F, Librandi, F, Lobley, GE and Trevisi, E 2016. Circulating amino acids in blood plasma during the peripartal period in dairy cows with different liver functionality index. Journal of Dairy Science 99, 2257–2267.CrossRefGoogle ScholarPubMed
Supplementary material: File

Minuti et al. supplementary material

Tables S1-S2

Download Minuti et al. supplementary material(File)
File 17.3 KB