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Coronary angiography and percutaneous coronary intervention in the porcine model: a practical guide to the procedure

Published online by Cambridge University Press:  20 September 2011

P. D. Williams ,
N. Malik  and
P. A. Kingston
P. D. Williams*
Affiliation:
The University of Manchester, Manchester Academic Health Science Centre, School of Biomedicine, Vascular Gene Therapy Unit, Core Technology Facility, 46 Grafton Street, Manchester M13 9NT, UK
N. Malik
Affiliation:
The University of Manchester, Manchester Academic Health Science Centre, School of Biomedicine, Vascular Gene Therapy Unit, Core Technology Facility, 46 Grafton Street, Manchester M13 9NT, UK
P. A. Kingston
Affiliation:
The University of Manchester, Manchester Academic Health Science Centre, School of Biomedicine, Vascular Gene Therapy Unit, Core Technology Facility, 46 Grafton Street, Manchester M13 9NT, UK
*
†E-mail: [email protected]
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Abstract

Assessment of safety and efficacy within the porcine coronary artery model remains a standard requirement for new therapies delivered to the coronary arteries before proceeding to clinical testing. Human coronary procedures carry a very low mortality rate; however, procedural mortality for porcine experiments is often high, despite these animals being young and free of atherosclerosis. Some of these deaths are due to poor technique, and therefore avoidable. However, despite the wide use of this model, a systematic description of the procedure has never been published. This article will detail how porcine angiography and stent implantation is performed in our institution and will discuss the relevant differences between humans and pigs with regard to anaesthesia, pharmacotherapy, vascular access, catheter selection and angiographic views. Important variations to the technique that have been reported are also covered.

Keywords

pigcoronary arterymethod
Type
Full Paper
Information
animal , Volume 6 , Issue 2 , 03 January 2012 , pp. 311 - 320
Copyright
Copyright © The Animal Consortium 2011

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