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Consumption of a high-salt diet by ewes during pregnancy alters nephrogenesis in 5-month-old offspring

Published online by Cambridge University Press:  19 March 2012

S. H. Tay ,
D. Blache ,
K. Gregg  and
D. K. Revell
S. H. Tay
Affiliation:
School of Animal Biology, The University of Western Australia, 35 Stirling Highway, Crawley, Western Australia 6009, Australia Commonwealth Scientific and Industrial Research Organisation (CSIRO) Livestock Industries, Private Bag 5, Wembley, Western Australia 6913, Australia Future Farm Industries Cooperative Research Centre, The University of Western Australia, 35 Stirling Highway, Crawley, Western Australia 6009, Australia
D. Blache
Affiliation:
School of Animal Biology, The University of Western Australia, 35 Stirling Highway, Crawley, Western Australia 6009, Australia
K. Gregg
Affiliation:
Western Australian Biomedical Research Institute & Centre for Health Innovation Research Institute, School of Biomedical Sciences, Curtin University, Perth, Western Australia 6845, Australia
D. K. Revell
Affiliation:
School of Animal Biology, The University of Western Australia, 35 Stirling Highway, Crawley, Western Australia 6009, Australia Commonwealth Scientific and Industrial Research Organisation (CSIRO) Livestock Industries, Private Bag 5, Wembley, Western Australia 6913, Australia Future Farm Industries Cooperative Research Centre, The University of Western Australia, 35 Stirling Highway, Crawley, Western Australia 6009, Australia
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Abstract

Maternal nutrition during pregnancy can affect kidney development in the foetus, which may lead to adverse consequences in the mature kidney. It was expected that high-salt intake by pregnant ewes would lead to a reduction in foetal glomerular number but that the ovine kidney would adapt to maintain homoeostasis, in part by increasing the size of each glomerulus. Merino ewes that were fed either a control (1.5% NaCl) or high-salt (10.5% NaCl) diet during pregnancy, as well as their 5-month-old offspring, were subjected to a dietary salt challenge, and glomerular number and size and sodium excretion were measured. The high-salt offspring had 20% fewer glomeruli compared with the control offspring (P < 0.001), but they also had larger glomerular radii compared with the control offspring (P < 0.001). Consequently, the cross-sectional area of glomeruli was 18% larger in the high-salt offspring than in the control offspring (P < 0.05). There was no difference in the daily urinary sodium excretion between the two offspring groups (P > 0.05), although the high-salt offspring produced urine with a higher concentration of sodium. Our results demonstrated that maternal high-salt intake during pregnancy affected foetal nephrogenesis, altering glomerular number at birth. However, the ability to concentrate and excrete salt was not compromised, which indicates that the kidney was able to adapt to the reduction in the number of glomeruli.

Keywords

foetal programmingglomerulisalt intakesheepsodium excretion
Type
Physiology and functional biology of systems
Information
animal , Volume 6 , Issue 11 , November 2012 , pp. 1803 - 1810
Copyright
Copyright © The Animal Consortium 2012

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