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Weeping forsythia extract alleviates dexamethasone-induced oxidative injury of breast muscles in broilers

Published online by Cambridge University Press:  07 May 2019

L. Pan ,
X. K. Ma ,
P. F. Zhao  and
X. S. Piao
L. Pan
Affiliation:
Laboratory of Gastrointestinal Microbiology, Jiangsu Key Laboratory of Gastrointestinal Nutrition and Animal Health, National Center for International Research on Animal Gut Nutrition, College of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, Jiangsu, China State Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China
X. K. Ma
Affiliation:
State Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China
P. F. Zhao
Affiliation:
State Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China
X. S. Piao*
Affiliation:
State Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China
*
†E-mail: [email protected]
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Abstract

Antioxidants have been always used to improve post-slaughter meat quality in broilers subjected to stress. Forsythia suspensa extract (FSE), a traditional Chinese herbal medicine, is generally regarded as a natural source of antioxidants. Therefore, the objective of this study was to test the hypothesis that FSE could protect post-slaughter breast muscles against oxidative injury induced by dexamethasone (DEX) mimicking chronic physiological stress in poultry production. Average daily gain and feed efficiency of poultry were suppressed by DEX and improved by FSE (P < 0.05). Dexamethasone caused the decrease in the redness value and the increase in the lightness and yellowness values and drip loss of the breast muscles (P < 0.05), and FSE had the converse effects (P < 0.05). Dietary FSE supplementation decreased monounsaturated fatty acid (FA) and increased polyunsaturated FA in breast muscles of broilers (P < 0.05). In addition, FSE decreased malondialdehyde and carbonyl content in the breast muscles of DEX-treated broilers (P < 0.05). The inhibition of 1,1-diphenyl-2-picryl-hydrazyl in the breast muscles was decreased by DEX and increased by FSE (P < 0.05). Total-antioxidant capacity and glutathione peroxidase activity in the breast muscles were decreased in birds subjected to DEX and increased in birds supplemented with FSE (P < 0.05). Totally, DEX suppressed growth performance and induced breast muscle oxidative injury in broilers, and FSE supplementation improved antioxidant capacity to attenuate these adverse effects. Therefore, FSE could be a potential natural antioxidant to alleviate oxidative injury of the breast muscles in broilers and to improve the meat quality for human consumption.

Keywords

antioxidant capacityChinese herbal medicinechronic stressmeat qualitypoultry
Type
Research Article
Information
animal , Volume 13 , Issue 11 , November 2019 , pp. 2660 - 2668
Copyright
© The Animal Consortium 2019 

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Footnotes

a

These authors contributed equally to the work.

References

Blois, MS 1958. Antioxidant determination by the use of a stable free radical. Nature 181, 1199–1200.CrossRefGoogle Scholar
Cheng, K, Song, ZH, Zheng, XC, Zhang, H, Zhang, JF, Zhang, LL, Zhou, YM and Wang, T 2016. Effects of dietary vitamin E type on the growth performance and antioxidant capacity in cyclophosphamide immunosuppressed broilers. Poultry Science 96, 1159–1166.Google Scholar
Dhabhar, FS 2009. Enhancing versus suppressive effects of stress on immune function: Implications for immunoprotection and immunopathology. Neuroimmunomodulation 16, 300–317.CrossRefGoogle ScholarPubMed
Dong, H, Lin, H, Jiao, HC, Song, ZG, Zhao, JP and Jiang, KJ 2007. Altered development and protein metabolism in skeletal muscles of broiler chickens (Gallus gallus domesticus) by corticosterone. Comparative Biochemistry and Physiology A 147, 189–195.CrossRefGoogle ScholarPubMed
Eid, Y, Ebeid, T and Younis, H 2006. Vitamin E supplementation reduces dexamethasone induced oxidative stress in chicken semen. British Poultry Science 47, 350–356.CrossRefGoogle ScholarPubMed
El-Senousey, HK, Chen, B, Wang, JY, Atta, AM, Mohamed, FR and Nie, QH 2018. Effects of dietary vitamin C, vitamin E, and alpha-lipoic acid supplementation on the antioxidant defense system and immune-related gene expression in broilers exposed to oxidative stress by dexamethasone. Poultry Science 97, 30–38.CrossRefGoogle ScholarPubMed
Estévez, M 2015. Oxidative damage to poultry: from farm to fork. Poultry Science 94, 1368–1378.CrossRefGoogle ScholarPubMed
Fellenberg, MA and Speisky, H 2006. Antioxidants: their effects on broiler oxidative stress and its meat oxidative stability. Worlds Poultry Science Journal 62, 53–70.CrossRefGoogle Scholar
Gao, J, Lin, H, Song, ZG and Jiao, HC 2008. Corticosterone alters meat quality by changing pre- and post-slaughter muscle metabolism. Poultry Science 87, 1609–1617.CrossRefGoogle Scholar
Gao, J, Lin, H, Wang, XJ, Song, ZG and Jiao, HC 2010. Vitamin E supplementation alleviates the oxidative stress induced by dexamethasone treatment and improves meat quality in broiler chickens. Poultry Science 89, 318–327.CrossRefGoogle ScholarPubMed
Glantzounis, GK, Tsimoyiannis, EC, Kappas, AM and Galariso, DA 2005. Uric acid and oxidative stress. Current Pharmaceutical Design 11, 4145–4151.CrossRefGoogle ScholarPubMed
Le Bihan-Duval, E, Debut, M, Berri, CM, Sellier, N, Santé-Lhoutellier, V, Jégo, Y and Beaumont, C 2008. Chicken meat quality: genetic variability and relationship with growth and muscle characteristics. BMC Genetics 9, 53.CrossRefGoogle ScholarPubMed
Lin, H, Decuypere, E and Buyse, J 2004. Oxidative stress induced by corticosterone administration in broiler chickens (Gallus gallus domesticus) 1. Chronic Exposure. Comparative Biochemistry and Physiology B 139, 737–744.CrossRefGoogle ScholarPubMed
Lin, H, Sui, SJ, Jiao, HC, Jiang, KJ, Zhao, JP and Dong, H 2007. Effects of diet and stress mimicked by corticosterone administration on early postmortem muscle metabolism of broiler chickens. Poultry Science 86, 545–554.CrossRefGoogle ScholarPubMed
Lu, L, Ji, C, Luo, XG, Liu, B and Yu, SX 2006. The effect of supplemental manganese in broiler diets on abdominal fat deposition and meat quality. Animal Feed Science and Technology 129, 49–59.CrossRefGoogle Scholar
Lu, T, Harper, AF, Zhao, J, Estienne, MJ and Dalloul, RA 2014. Supplementing antioxidants to pigs fed diets high in oxidants: I. Effects on growth performance, liver function, and oxidative status. Journal of Animal Science 92, 5455–5463.CrossRefGoogle ScholarPubMed
Lu, T, Piao, XL, Zhang, Q, Wang, D, Piao, XS and Kim, SW 2010. Protective effects of Forsythia suspensa extract against oxidative stress induced by diquat in rats. Food and Chemical Toxicology 48, 764–770.CrossRefGoogle ScholarPubMed
Lv, ZP, Peng, YZ, Zhang, BB, Fan, H, Liu, D and Guo, YM 2018. Glucose and lipid metabolism disorders in the chickens with dexamethasone-induced oxidative stress. Journal of Animal Physiology and Animal Nutrition 102, e706–e717.CrossRefGoogle ScholarPubMed
Matkowski, A, Jamiolkowska-Kozlowska, W and Nawrot, I 2013. Chinese medicinal herbs as source of antioxidant compounds – where tradition meets the future. Current Medicinal Chemistry 20, 984–1004.Google ScholarPubMed
Min, YN, Sun, TT, Niu, ZY and Liu, FZ 2016. Vitamin C and vitamin E supplementation alleviates oxidative stress induced by dexamethasone and improves fertility of breeder roosters. Animal Reproduction Science 171, 1–6.CrossRefGoogle ScholarPubMed
National Research Council (NRC) 1994. Nutrient requirements of poultry , 9th revised edition. National Academies Press, Washington, DC, USA.Google Scholar
Pan, L, Ma, XK, Zhao, PF, Shang, QH, Long, SF, Wu, Y and Piao, XS 2018a. Forsythia suspensa extract attenuates breast muscle oxidative injury induced by transport stress in broilers. Poultry Science 97, 1554–1563.CrossRefGoogle ScholarPubMed
Pan, L, Zhao, PF, Ma, XK, Shang, QH, Long, SF, Wu, Y, Wang, W and Piao, XS 2018b. Forsythia suspensa extract protects broilers against breast muscle oxidative injury induced by corticosterone mimicked pre-slaughter acute stress. Poultry Science 97, 2095–2105.CrossRefGoogle ScholarPubMed
Perai, AH, Kermanshahi, H, Nassiri Moghaddam, H and Zarban, A 2014. Effects of supplemental vitamin C and chromium on metabolic and hormonal responses, antioxidant status, and tonic immobility reactions of transported broiler chickens. Biological Trace Element Research 157, 224–233.CrossRefGoogle ScholarPubMed
Petracci, M, Mudalal, S and Cavani, FSC 2015. Meat quality in fast-growing broiler chickens. Worlds Poultry Science Journal 71, 363–374.CrossRefGoogle Scholar
Puvadolpirod, S and Thaxton, JP 2000a. Model of physiological stress in chickens 1. Response parameters. Poultry Science 79, 363–369.CrossRefGoogle ScholarPubMed
Puvadolpirod, S and Thaxton, JP 2000b. Model of physiological stress in chickens 3. Temporal patterns of response. Poultry Science 79, 377–382.CrossRefGoogle ScholarPubMed
Salma, U, Miah, AG, Maki, T, Nishimura, M and Tsujii, H 2007. Effect of dietary Rhodobacter capsulatus on cholesterol concentration and fatty acid composition in broiler meat. Poultry Science 86, 1920–1926.CrossRefGoogle ScholarPubMed
Samarth, RM, Panwar, M, Kumar, M, Soni, A, Kumar, M and Kumar, A 2007. Evaluation of antioxidant and radical-scavenging activities of certain radioprotective plant extracts. Food Chemistry 106, 868–873.CrossRefGoogle Scholar
Wang, L, Piao, XL, Kim, SW, Piao, XS, Shen, YB and Lee, HS 2008. Effects of Forsythia suspensa extract on growth performance, nutrient digestibility, and antioxidant activities in broiler chickens under high ambient temperature. Poultry Science 87, 1287–1294.CrossRefGoogle ScholarPubMed
Wang, XF, Zhu, XD, Li, YJ, Liu, Y, Li, JL, Gao, F, Zhou, GH and Zhang, L 2015. Effect of dietary creatine monohydrate supplementation on muscle lipid peroxidation and antioxidant capacity of transported broilers in summer. Poultry Science 94, 2797–2804.CrossRefGoogle Scholar
Watteyn, A, Wyns, H, Plessers, E, Russo, E, De Baere, S, De Backer, P and Croubels, S 2013. Pharmacokinetics of dexamethasone after intravenous and intramuscular administration in broiler chickens. Veterinary Journal 195, 216–220.CrossRefGoogle ScholarPubMed
Yuan, L, Lin, H, Jiang, KJ, Jiao, HC and Song, ZG 2008. Corticosterone administration and high energy feed result in enhanced fat accumulation and insulin resistance in broiler chickens. British Poultry Science 49, 487–495.CrossRefGoogle Scholar
Zeng, ZK, Li, QY, Piao, XS, Liu, JD, Zhao, PF, Xu, X, Zhang, S and Niu, S 2014. Forsythia suspensa extract attenuates corticosterone-induced growth inhibition, oxidative injury, and immune depression in broilers. Poultry Science 93, 1774–1781.CrossRefGoogle ScholarPubMed
Zhang, HY, Piao, XS, Zhang, Q, Li, PF, Yi, JQ, Liu, JD, Li, QY and Wang, GQ 2013. The effects of Forsythia suspensa extract and berberine on growth performance, immunity, antioxidant activities, and intestinal microbiota in broilers under high stocking density. Poultry Science 92, 1981–1988.CrossRefGoogle ScholarPubMed
Zhang, WH, Gao, F, Zhu, QF, Li, C, Jiang, Y, Dai, SF and Zhou, GH 2011. Dietary sodium butyrate alleviates the oxidative stress induced by corticosterone exposure and improves meat quality in broiler chickens. Poultry Science 90, 2592–2599.CrossRefGoogle ScholarPubMed