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Immune and oxidative response to linseed in the diet of periparturient Holstein cows

Published online by Cambridge University Press:  19 March 2015

M. Đidara ,
N. Poljičak-Milas ,
S. Milinković-Tur ,
T. Mašek ,
J. Šuran ,
M. Pavić ,
M. Kardum  and
M. Šperanda
M. Đidara*
Affiliation:
Department of Animal Science, Faculty of Agriculture, K. P. Svacica 1D, 31000 Osijek, Croatia
N. Poljičak-Milas
Affiliation:
Department of Pathophysiology, Veterinary Faculty, Heinzelova 55, 10000 Zagreb, Croatia
S. Milinković-Tur
Affiliation:
Department of Physiology and Radiobiology, Veterinary Faculty, Heinzelova 55, 10000 Zagreb, Croatia
T. Mašek
Affiliation:
Department of Animal Nutrition and Dietetics, Veterinary Faculty, Heinzelova 55, 10000 Zagreb, Croatia
J. Šuran
Affiliation:
Department of Pharmacology and Toxicology, Veterinary Faculty, Heinzelova 55, 10000 Zagreb, Croatia
M. Pavić
Affiliation:
Department of Animal Science, Faculty of Agriculture, K. P. Svacica 1D, 31000 Osijek, Croatia
M. Kardum
Affiliation:
Department of Pathophysiology, Veterinary Faculty, Heinzelova 55, 10000 Zagreb, Croatia
M. Šperanda
Affiliation:
Department of Animal Science, Faculty of Agriculture, K. P. Svacica 1D, 31000 Osijek, Croatia
*
†E-mail: [email protected]
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Abstract

The aim of this research was to determine the influence of dietary replacement of n-6 with n-3 polyunsaturated fatty acids on cellular immunity and oxidative stress in the transition period dairy cows. The experiment was conducted on 20 dairy Holstein cows from 3±1 weeks before parturition until the 6th week of lactation. Both groups were fed an iso-energetic and iso-nitrogenous diet. Soybean meal from control (C) group was replaced with linseed in the experimental (LS) group. Cellular immunity and oxidative stress were measured on days −10, 1, 21 and 42 relative to parturition. During the entire experimental period, the proportion of CD45+ cells was lower (P<0.05) in LS group compared with the C group. The phagocytosis ability and phagocytosis index of cows fed with n-3 fatty acids were significantly reduced (P<0.05) compared with the group of cows fed with n-6 fatty acids. The most severe decrease in phagocytosis ability was on day −10 and 1 relative to parturition. The activity of superoxide dismutase (P<0.05) and plasma glutathione peroxidase (P<0.05) increased around calving, although activities were not influenced by dietary treatment. Increased malondialdehyde concentration (P<0.05) was influenced by dietary n-3 fatty acids and the time relative to parturition. The immune suppression was most pronounced during periparturient period. In that matter we can conclude that not only dietary n-3 fatty acids but also oxidative stress, which reached peak at time of parturition, contributed to the reduced cellular immunity during the periparturient period.

Keywords

dairy cowsimmune responseoxidative stresslinseedfatty acids
Type
Research Article
Information
animal , Volume 9 , Issue 8 , August 2015 , pp. 1349 - 1354
Copyright
© The Animal Consortium 2015 

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