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Haptoglobin serum concentration is a suitable biomarker to assess the efficacy of a feed additive in pigs

Published online by Cambridge University Press:  01 April 2010

Y. Saco ,
L. Fraile ,
M. Giménez ,
R. Pato ,
M. Montoya  and
A. Bassols
Y. Saco
Affiliation:
Departament de Bioquímica i Biologia Molecular i Servei de Bioquímica Clínica Veterinària, Facultat de Veterinària, Universitat Autònoma de Barcelona, 08193 Bellaterra, Barcelona, Spain
L. Fraile
Affiliation:
Centre de Recerca en Sanitat Animal (CReSA), UAB-IRTA, Campus de la Universitat Autònoma de Barcelona, 08193 Bellaterra, Barcelona, Spain Institut de Recerca i Tecnologia Agroalimentàries (IRTA), Barcelona, Spain
M. Giménez
Affiliation:
Departament de Bioquímica i Biologia Molecular i Servei de Bioquímica Clínica Veterinària, Facultat de Veterinària, Universitat Autònoma de Barcelona, 08193 Bellaterra, Barcelona, Spain
R. Pato
Affiliation:
Departament de Bioquímica i Biologia Molecular i Servei de Bioquímica Clínica Veterinària, Facultat de Veterinària, Universitat Autònoma de Barcelona, 08193 Bellaterra, Barcelona, Spain
M. Montoya
Affiliation:
Centre de Recerca en Sanitat Animal (CReSA), UAB-IRTA, Campus de la Universitat Autònoma de Barcelona, 08193 Bellaterra, Barcelona, Spain Institut de Recerca i Tecnologia Agroalimentàries (IRTA), Barcelona, Spain
A. Bassols*
Affiliation:
Departament de Bioquímica i Biologia Molecular i Servei de Bioquímica Clínica Veterinària, Facultat de Veterinària, Universitat Autònoma de Barcelona, 08193 Bellaterra, Barcelona, Spain
*
†E-mail: [email protected]
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Abstract

Levels of haptoglobin and Pig-major acute phase protein (MAP) were analysed in animals from a commercial herd receiving or not a diet enriched with an additive. The group receiving the additive exhibited a decrease in haptoglobin after 3 weeks, suggesting that a better health status has been established, together with an improvement in total body weight and average daily gain. In contrast, Pig-MAP does not significantly change under these conditions. Aujeszky live modified vaccination, which is compulsory in Spain, did cause a significant increment in haptoglobin serum concentration although it did not affect Pig-MAP. The response of acute phase proteins to vaccination was similar in both control and additive-treated groups. Interleukins (IL)-1β and IL-6 was below the detection limits in most of the animals. In conclusion, this study shows that haptoglobin serum concentration, but not Pig-MAP, is a good biomarker to monitorize production parameters and for monitoring Aujeszky modified live vaccine in pigs reared under standard commercial conditions.

Keywords

acute phase proteins, feed additive, Aujeszky vaccine, swine
Type
Full Paper
Information
animal , Volume 4 , Issue 9 , September 2010 , pp. 1561 - 1567
Copyright
Copyright © The Animal Consortium 2010

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Footnotes

a

Yolanda Saco and Lorenzo Fraile equally contributed to this paper.

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