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Effects of γ-aminobutyric acid on feed intake, growth performance and expression of related genes in growing lambs

Published online by Cambridge University Press:  07 November 2014

D. M. Wang ,
B. Chacher ,
H. Y. Liu ,
J. K. Wang ,
J. Lin  and
J. X. Liu
D. M. Wang
Affiliation:
MoE Key Laboratory of Molecular Animal Nutrition, Institute of Dairy Sciences, College of Animal Sciences, Zhejiang University, Hangzhou 310058, P. R. China
B. Chacher
Affiliation:
MoE Key Laboratory of Molecular Animal Nutrition, Institute of Dairy Sciences, College of Animal Sciences, Zhejiang University, Hangzhou 310058, P. R. China
H. Y. Liu
Affiliation:
MoE Key Laboratory of Molecular Animal Nutrition, Institute of Dairy Sciences, College of Animal Sciences, Zhejiang University, Hangzhou 310058, P. R. China
J. K. Wang
Affiliation:
MoE Key Laboratory of Molecular Animal Nutrition, Institute of Dairy Sciences, College of Animal Sciences, Zhejiang University, Hangzhou 310058, P. R. China
J. Lin
Affiliation:
MoE Key Laboratory of Molecular Animal Nutrition, Institute of Dairy Sciences, College of Animal Sciences, Zhejiang University, Hangzhou 310058, P. R. China
J. X. Liu*
Affiliation:
MoE Key Laboratory of Molecular Animal Nutrition, Institute of Dairy Sciences, College of Animal Sciences, Zhejiang University, Hangzhou 310058, P. R. China
*
†E-mail: [email protected]
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Abstract

This study was conducted to investigate the effects of rumen-protected γ-aminobutyric acid (GABA) on feed intake, growth performance and expression of related genes in growing lambs. A total of 24 lambs weaned at age of 50 days were divided into four block of six based on their BW, six lambs within a block were allocated to three pairs, which were then assigned randomly to three treatments with addition of rumen-protected GABA at levels of 0, 70 or 140 mg/day for 6 weeks. Dry matter intake was recorded weekly in three consecutive days, and BW was recorded every two weeks. At the end of the trial, four lambs from each group were slaughtered, and duodenum and ileum mucosa were obtained for measurement of mRNA abundance of GABA receptor and cholecystokinin receptor. Dry matter intake was higher (P<0.01) in the lambs fed 140 mg/day GABA than that in the control or 70 mg GABA-fed lambs. Average daily gain and nutrients digestibility were not different (P>0.05) among treatments. Lambs fed 140 mg/day GABA had higher mRNA abundance of GABA-B receptor (P<0.01) and lower mRNA abundance of cholecystokinin-2 receptor (P<0.01) in duodenum mucosa. Serum CCK content was lower (P<0.01) in lambs fed 140 mg/day GABA than that in control. It is indicated that GABA may enhance feed intake by regulating GABA- and cholecystokinin-related genes.

Keywords

γ-aminobutyric acidγ-aminobutyric acid-B receptorcholecystokinin-2 receptorfeed intakegrowing lambs
Type
Research Article
Information
animal , Volume 9 , Supplement 3 , March 2015 , pp. 445 - 448
Copyright
© The Animal Consortium 2014 

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