Hostname: page-component-586b7cd67f-rcrh6 Total loading time: 0 Render date: 2024-11-28T02:46:08.706Z Has data issue: false hasContentIssue false
  • English
  • Français

Detection of quantitative trait loci for teat number and female reproductive traits in Meishan × Large White F2 pigs

Published online by Cambridge University Press:  13 May 2008

J. P. Bidanel ,
A. Rosendo ,
N. Iannuccelli ,
J. Riquet ,
H. Gilbert ,
J. C. Caritez ,
Y. Billon ,
Y. Amigues ,
A. Prunier  and
D. Milan
J. P. Bidanel*
Affiliation:
INRA, UR337 Station de Génétique quantitative et appliquée F-78350 Jouy-en-Josas, France
A. Rosendo
Affiliation:
INRA, UR337 Station de Génétique quantitative et appliquée F-78350 Jouy-en-Josas, France
N. Iannuccelli
Affiliation:
INRA, UMR444 Laboratoire de Génétique Cellulaire F-31320 Castanet-Tolosan, France
J. Riquet
Affiliation:
INRA, UMR444 Laboratoire de Génétique Cellulaire F-31320 Castanet-Tolosan, France
H. Gilbert
Affiliation:
INRA, UR337 Station de Génétique quantitative et appliquée F-78350 Jouy-en-Josas, France
J. C. Caritez
Affiliation:
INRA, UE967 Génétique Expérimentale en Productions Animales F-17700 Surgères, France
Y. Billon
Affiliation:
INRA, UE967 Génétique Expérimentale en Productions Animales F-17700 Surgères, France
Y. Amigues
Affiliation:
LABOGENA, F-78350 Jouy-en-Josas, France
A. Prunier
Affiliation:
INRA, UMR1079 Systèmes d’Elevage, Nutrition Animale et Humaine F-35590 Saint-Gilles, France
D. Milan
Affiliation:
INRA, UMR444 Laboratoire de Génétique Cellulaire F-31320 Castanet-Tolosan, France
*
E-mail: [email protected]
Get access

Abstract

A quantitative trait locus (QTL) analysis of female reproductive data from a three-generation experimental cross between Meishan (MS) and Large White (LW) pig breeds is presented. Six F1 boars and 23 F1 sows, progeny of six LW boars and six MS sows, produced 573 F2 females and 530 F2 males. Six traits, i.e. teat number (TN), age at puberty (AP), ovulation rate (OR), weight at mating (WTM), number of viable embryos (NVE) and embryo survival (ES) at 30 days of gestation were analysed. Animals were genotyped for a total of 137 markers covering the entire porcine genome. Analyses were carried out based on interval mapping methods, using a line-cross (LC) regression and a half–full sib (HFS) maximum likelihood test. Genome-wide (GW) highly significant (P < 0.001) QTL were detected for WTM on SSC 7 and for AP on SSC 13. They explained, respectively, 14.5% and 8.9% of the trait phenotypic variance. Other GW significant (P < 0.05) QTL were detected for TN on SSC 3, 7, 8, 16 and 17, for OR on SSC 4 and 5, and for ES on SSC 9. Two additional chromosome-wide significant (P < 0.05) QTL were detected for TN, three for WTM, four for AP, three for OR, three for NVE and two for ES. With the exception of the two above-mentioned loci, the QTL explained from 1.2% to 4.6% of trait phenotypic variance. QTL alleles were in most cases not fixed in the grand-parental populations and Meishan alleles were not systematically associated with higher reproductive performance.

Keywords

gene mappingquantitative trait locuspigreproduction traitsteat number
Type
Full Paper
Information
animal , Volume 2 , Issue 6 , June 2008 , pp. 813 - 820
Copyright
Copyright © The Animal Consortium 2008

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Beeckmann, P, Moser, G, Bartenschlager, H, Reiner, G, Geldermann, H 2003. Linkage and QTL mapping for Sus scrofa chromosome 8. Journal of Animal Breeding and Genetics 120, 66–73.CrossRefGoogle Scholar
Bidanel, JP, Rothschild, M 2002. Current status of quantitative trait locus mapping in pigs. Pig News and Information 23, 39N–54N.Google Scholar
Bidanel JP, Caritez JC and Lagant H 1990a. Ovulation rate and embryo survival in gilts and sows with variable proportions of Meishan and Large White genes. In Chinese Pig Symposium, 5–6 July 1990, Toulouse, France, pp. 109–110.Google Scholar
Bidanel, JP, Caritez, JC, Legault, C 1990b. Ten years of experiments with Chinese pigs in France. 1. Breed evaluation. Pig News and Information 11, 345–348.Google Scholar
Bidanel, JP, Milan, D, Iannuccelli, N, Amigues, Y, Boscher, MY, Bourgeois, F, Caritez, JC, Gruand, J, Le Roy, P, Lagant, H, Quintanilla, R, Renard, C, Gellin, J, Ollivier, L, Chevalet, C 2001. Detection of quantitative trait loci for growth and fatness in pigs. Genetics, Selection, Evolution 33, 289–309.CrossRefGoogle ScholarPubMed
Buske, B, Sternstein, I, Brockmann, G 2006. QTL and candidate genes for fecundity in sows. Animal Reproduction Science 95, 167–183.CrossRefGoogle ScholarPubMed
Campbell, EMG, Nonneman, D, Rohrer, GA 2003. Fine mapping a quantitative trait locus affecting ovulation rate in swine on chromosome 8. Journal of Animal Science 81, 1706–1714.CrossRefGoogle ScholarPubMed
Cassady, JP, Johnson, RK, Pomp, D, Rohrer, GA, Van Vleck, LD, Spiegel, EK, Gilson, KM 2001. Identification of quantitative trait loci affecting reproduction in pigs. Journal of Animal Science 79, 623–633.CrossRefGoogle ScholarPubMed
De Koning, DJ, Rattink, AP, Harlizius, B, Van Arendonk, JAM, Brascamp, EW, Groenen, MAM 2000. Genome-wide scan for body composition in pigs reveals important role of imprinting. Proceedings of the National Academy of Sciences of the United States of America 97, 7947–7950.Google ScholarPubMed
De Koning, DJ, Rattink, AP, Harlizius, B, Groenen, MAM, Brascamp, EW, Van Arendonk, JAM 2001. Detection and characterization of quantitative trait loci for growth and reproduction traits in pigs. Livestock Production Science 72, 185–198.CrossRefGoogle Scholar
Gilbert, H, Bidanel, JP, Milan, D, Le Roy, P 2007. Linked and pleiotropic QTL influencing carcass composition traits detected on porcine chromosome 7. Genetical Research 89, 65–72.CrossRefGoogle ScholarPubMed
Green, P, Falls, K, Crooks, S 1990. Documentation for CRIMAP version 2.4. Washington University School of Medicine, St. Louis.Google Scholar
Haley, CS, Lee, GJ 1992. Genetic factors contributing to variation in litter size in British Large White gilts. Livestock Production Science 30, 99–113.CrossRefGoogle Scholar
Haley, CS, Knott, SA, Elsen, J 1994. Mapping quantitative trait loci in crosses between outbred lines using least squares. Genetics 136, 1195–1207.CrossRefGoogle ScholarPubMed
Hu, Z, Dracheva, S, Jang, W, Maglott, D, Bastiaansen, J, Rothschild, MF, Reecy, JM 2005. A QTL resource and comparison tool for pigs: PigQTLDB. Mammalian Genome 16, 792–800.CrossRefGoogle ScholarPubMed
King, AH, Jiang, Z, Gibson, JP, Haley, CS, Archibald, AL 2003. Mapping quantitative trait loci affecting female reproductive traits on porcine chromosome 8. Biology of Reproduction 68, 2172–2179.CrossRefGoogle ScholarPubMed
Knott, SA, Marklund, L, Haley, CS, Andersson, K, Davies, W, Ellegren, H, Fredholm, M, Hansson, I, Hoyhem, B, Lundström, K, Moller, M, Andersson, L 1998. Multiple marker mapping of quantitative trait loci in a cross between outbred Wild Boar and Large White pigs. Genetics 149, 1069–1080.CrossRefGoogle Scholar
Lande, R, Thompson, R 1990. Efficiency of marker-assisted selection in the improvement of quantitative traits. Genetics 124, 743–756.CrossRefGoogle ScholarPubMed
Le Roy P, Elsen JM, Boichard D, Mangin B, Bidanel JP and Goffinet B 1998. An algorithm for QTL detection in mixture of full and half sib families. In Proceedings of the 6th World Congress on Genetics Applied to Livestock Production, Armidale, 1998, vol. 26, pp. 257–260.Google Scholar
Milan, D, Bidanel, JP, Iannuccelli, N, Riquet, J, Amigues, Y, Boscher, MY, Bourgeois, F, Caritez, JC, Gruand, J, Le Roy, P, Lagant, H, Quintanilla, R, Renard, C, Gellin, J, Ollivier, L, Chevalet, C 2002. Detection of quantitative trait loci for carcass composition traits in pigs. Genetics, Selection, Evolution 34, 705–728.CrossRefGoogle ScholarPubMed
Noguera JL, Rodriguez MC, Varona L, Tomas A, Munoz G, Ramirez O, Barragan C, Arque M, Bidanel JP, Amills M, Ovilo C and Sanchez A 2006. Epistasis is a fundamental component of the genetic architecture of prolificacy in pigs. In Proceedings of the 8th World Congress on Genetics Applied to Livestock Production, Belo Horizonte, Minas Gerais, Brazil, communication no 11-06.Google Scholar
Prunier, A, Meunier-Salaün, MC 1989. The influence of boar stimulation on puberty attainment in tethered and group penned gilts. Theriogenology 32, 949–959.CrossRefGoogle Scholar
Rathje, TA, Rohrer, GA, Johnson, RK 1997. Evidence for quantitative trait loci affecting ovulation rate in pigs. Journal of Animal Science 75, 1486–1494.CrossRefGoogle ScholarPubMed
Rohrer, GA 2000. Identification of quantitative trait loci affecting birth characters and accumulation of backfat and weight in a Meishan-White Composite resource population. Journal of Animal Science 78, 2547–2553.CrossRefGoogle Scholar
Rohrer, GA, Ford, JJ, Wise, TH, Vallet, JL, Christenson, RK 1999. Identification of quantitative trait loci affecting female reproductive traits in a multigeneration Meishan-White composite swine population. Journal of Animal Science 77, 1385–1391.CrossRefGoogle Scholar
Rothschild, MF, Bidanel, JP 1998. Biology and genetics of reproduction. In The genetics of the pig, pp. 313–343. Cab International, Wallingford, UK.Google Scholar
Sanchez, MP, Bidanel, JP, Zhang, S, Naveau, J, Burlot, T, Le Roy, P 2003. Likelihood and Bayesian analyses reveal major genes affecting body composition, carcass, meat quality and the number of false teats in a Chinese European pig line. Genetics, Selection, Evolution 35, 385–402.CrossRefGoogle Scholar
SAS Institute 1999. User’s Guide: statistics. In Statistical Analysis Systems Institute Inc., Cary, NC.Google Scholar
Seaton, GGR, Haley, CS, Knott, SA, Kearsey, M, Visscher, PM 2002. QTL Express: mapping quantitative trait loci in simple and complex pedigrees. Bioinformatics 18, 339–340.CrossRefGoogle ScholarPubMed
Tribout, T, Iannuccelli, N, Druet, T, Gilbert, H, Riquet, J, Guéblez, R, Mercat, MJ, Bidanel, JP, Milan, D, Le Roy, P 2008. Detection of quantitative trait loci for reproduction and production traits in Large White and French Landrace pig populations. Genetics, Selection, Evolution 40, 61–78.Google ScholarPubMed
Wada, Y, Akita, T, Awata, T, Furukawa, T, Sugai, N, Inage, Y, Ishii, K, Ito, Y, Kobayashi, E, Kusumoto, H, Matsumoto, T, Mikawa, S, Miyake, M, Murase, A, Shimanuki, S, Sugiyama, T, Uchida, Y, Yanai, S, Yasue, H 2000. Quantitative trait loci (QTL) analysis in a Meishan x Gottingen cross population. Animal Genetics 31, 376–384.CrossRefGoogle Scholar
Wilkie, PJ, Paszek, AA, Beattie, CW, Alexander, LJ, Wheeler, MB, Schook, LB 1999. A genomic scan of porcine reproductive traits reveals possible quantitative trait loci (QTLs) for number of corpora lutea. Mammalian Genome 10, 573–578.CrossRefGoogle ScholarPubMed