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Analysis of single nucleotide polymorphisms variation associated with important economic and computed tomography measured traits in Texel sheep

Published online by Cambridge University Press:  17 October 2017

D. Garza Hernandez ,
S. Mucha ,
G. Banos ,
K. Kaseja ,
K. Moore ,
N. Lambe ,
J. Yates  and
L. Bunger
D. Garza Hernandez
Affiliation:
Animal and Veterinary Sciences, Scotland’s Rural College, Easter Bush, Midlothian EH25 9RG, Scotland, UK
S. Mucha
Affiliation:
Animal and Veterinary Sciences, Scotland’s Rural College, Easter Bush, Midlothian EH25 9RG, Scotland, UK Department of Genetics and Animal Breeding, Poznan University of Life Sciences, Wolynska 33, 60-637 Poznan, Poland
G. Banos
Affiliation:
Animal and Veterinary Sciences, Scotland’s Rural College, Easter Bush, Midlothian EH25 9RG, Scotland, UK Roslin Institute, University of Edinburgh, Easter Bush, Midlothian EH25 9RG, Scotland, UK
K. Kaseja
Affiliation:
Animal and Veterinary Sciences, Scotland’s Rural College, Easter Bush, Midlothian EH25 9RG, Scotland, UK
K. Moore
Affiliation:
Animal and Veterinary Sciences, Scotland’s Rural College, Easter Bush, Midlothian EH25 9RG, Scotland, UK
N. Lambe
Affiliation:
Animal and Veterinary Sciences, Scotland’s Rural College, Easter Bush, Midlothian EH25 9RG, Scotland, UK
J. Yates
Affiliation:
British Texel Sheep Society, National Agricultural Centre, Stoneleigh Park, Kenilworth, Warwickshire, CV8 2LG, UK
L. Bunger*
Affiliation:
Animal and Veterinary Sciences, Scotland’s Rural College, Easter Bush, Midlothian EH25 9RG, Scotland, UK
*
†E-mail: [email protected]
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Abstract

Sheep are an important part of the global agricultural economy. Growth and meat production traits are significant economic traits in sheep. The Texel breed is the most popular terminal sire breed in the UK, mainly selected for muscle growth and lean carcasses. This is a study based on a genome-wide association approach that investigates the links between some economically important traits, including computed tomography (CT) measurements, and molecular polymorphisms in UK Texel sheep. Our main aim was to identify single nucleotide polymorphisms (SNP) associated with growth, carcass, health and welfare traits of the Texel sheep breed. This study used data from 384 Texel rams. Data comprised ten traits, including two CT measured traits. The phenotypic data were placed in four categories: growth traits, carcass traits, health traits and welfare traits. De-regressed estimated breeding values (EBV) for these traits together with sire genotypes derived with the Ovine 50 K SNP array of Illumina were jointly analysed in a genome wide association analysis. Eight novel chromosome-wise significant associations were found for carcass, growth, health and welfare traits. Three significant markers were intronic variants and the remainder intergenic variants. This study is a first step to search for genomic regions controlling CT-based productivity traits related to body and carcass composition in a terminal sire sheep breed using a 50 K SNP genome-wide array. Results are important for the further development of strategies to identify causal variants associated with CT measures and other commercial traits in sheep. Independent studies are needed to confirm these results and identify candidate genes for the studied traits.

Keywords

sheepTexelcomputed tomographyassociatedgenome-wide association study
Type
Research Article
Information
animal , Volume 12 , Issue 5 , May 2018 , pp. 915 - 922
Copyright
© The Animal Consortium 2017 

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Footnotes

a

Present address: Universidad Autónoma de Nuevo León (UANL), Pedro de Alba S/N, Ciudad Universitaria, San Nicolás de los Garza 66451, N.L., México.

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