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Use of meloxicam, buprenorphine, and Maxilene® to assess a multimodal approach for piglet pain management, part 1: surgical castration

Published online by Cambridge University Press:  01 January 2023

AV Viscardi  and
PV Turner
AV Viscardi*
Affiliation:
Department of Pathobiology, University of Guelph, Guelph, ON, N1G 2W1, Canada
PV Turner
Affiliation:
Department of Pathobiology, University of Guelph, Guelph, ON, N1G 2W1, Canada Charles River Laboratories Inc, 251 Ballardvale St, Wilmington, MA 01887, USA
*
* Contact for correspondence: [email protected]
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Abstract

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Surgical castration of piglets is a routine procedure on commercial pig farms, to prevent boar taint and reduce aggression. This procedure is known to cause pain, yet piglets are often not provided appropriate analgesia for relief. The objective of this study was to assess a multimodal approach to managing post-castration pain in piglets, using 0.4 mg kg-1 meloxicam (MEL), 0.04 mg kg-1 buprenorphine (BUP), and Maxilene® (MAX). Efficacy was evaluated using behavioural indicators, vocalisation, and facial grimace analysis. Male piglets were randomly assigned to one of ten possible treatments (n = 15 piglets per treatment group): MEL + BUP + MAX (castrated or uncastrated); MEL + BUP (castrated or uncastrated); BUP + MAX (castrated or uncastrated); MEL + MAX (castrated or uncastrated); saline (castrated control); or sham (uncastrated control). Castrated piglets in the MEL + BUP + MAX, MEL + BUP, and BUP + MAX treatment groups displayed significantly fewer pain behaviours than piglets administered saline. MEL + MAX was insufficient in reducing surgical castration pain behaviours. At 24 h post-procedure, saline and MEL + MAX-castrated piglets displayed significantly more pain behaviours than all other treatment groups and time-points. Facial grimace analysis indicated that MEL + MAX-castrated piglets had significantly higher grimace scores than MEL + BUP (castrated and uncastrated) and BUP + MAX-uncastrated. There were no significant differences in emitted vocalisations between the analgesia-treated and saline-castrated piglets. All treatment groups with buprenorphine were effective in alleviating castration-associated pain behaviours, suggesting that opioid administration is beneficial for managing piglet castration pain.

Keywords

analgesiaanimal welfarecastrationmultimodalpain assessmentpiglet
Type
Articles
Information
Animal Welfare , Volume 28 , Issue 4 , November 2019 , pp. 487 - 498
Copyright
© 2019 Universities Federation for Animal Welfare

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