Hostname: page-component-78c5997874-fbnjt Total loading time: 0 Render date: 2024-11-19T00:48:48.708Z Has data issue: false hasContentIssue false

A review of scientific literature on inherited disorders in domestic horse breeds

Published online by Cambridge University Press:  01 January 2023

CD Bettley
Affiliation:
Preston Vets4Pets, 90 Moor Lane, Preston, Lancashire PR1 1JQ, UK
JM Cardwell
Affiliation:
Veterinary Epidemiology and Public Health, The Royal Veterinary College, Hawkshead Lane, North Mymms, Hatfield, Herts AL9 7TA, UK
LM Collins
Affiliation:
Queen's University Belfast, School of Biological Sciences, Medical Biology Centre, 97 Lisburn Road, Belfast BT9 7BL, UK
L Asher*
Affiliation:
School of Veterinary Medicine and Science, University of Nottingham, Sutton Bonington Campus, Loughborough, Leicestershire LE12 5RD, UK
*
* Contact for correspondence and requests for reprints: [email protected]
Rights & Permissions [Opens in a new window]

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

The full extent to which inherited disorders occur in different breeds of domestic horse (Equus caballus) has not been previously been investigated. A systematic search was carried out to review scientific literature on inherited disorders in domestic horse breeds and examine patterns in potentially inherited disorders. A two-part search was conducted: (i) electronic bibliographic databases for published studies; and (ii) existing online databases of inherited disorders in animals. A total of 230 papers were identified, discussing 102 inherited disorders in the horse. Few cases (17) were found in which disorders were reported to have a direct link to a conformational or phenotypic trait. Forty-nine breeds of domestic horse were described as being predisposed to one or more inherited disorders, but such predispositions did not distinguish between genetic or environmental causes. There were few patterns in the number of disorders to which breeds were reportedly predisposed or in the extent to which disorders were researched. The structure and grouping of disorders presented here could assist with standardisation in the terminology used for describing inherited disorders.

Type
Research Article
Copyright
© 2012 Universities Federation for Animal Welfare

References

Aleman, M 2008 A review of equine muscle disorders. Neuromuscular Disorders 18: 277287CrossRefGoogle ScholarPubMed
American Quarter Horse Association (AQHA) 2009 AQHA's HYPP Factsheet. http://www.aqha.com/association/registration/hypp.html. (Accessed 18 August 2009)Google Scholar
Asher, L, Diesel, G, Summers, JF, McGreevy, PD and Collins, LM 2009 Inherited defects in pedigree dogs I: disorders related to breed standards. The Veterinary Journal 182: 402411CrossRefGoogle ScholarPubMed
Bannasch, D 2008 Genetic testing and the future of equine genomics. Journal of Equine Veterinary Science 28: 645649CrossRefGoogle Scholar
Bateson, P 2010 Independent Inquiry into Dog Breeding. Micropress Ltd: Halesworth, UKGoogle Scholar
Collins, LM, Asher, L, Diesel, G, Summers, JF and McGreevy, PD 2010 Welfare epidemiology as a tool to assessing the welfare impact of inherited defects on the pedigree dog population. Animal Welfare 19(S): 6775Google Scholar
Collins, LM, Asher, L, Summers, J and McGreevy, P 2011 Getting priorities straight: risk assessment and decision-making in the improvement of inherited disorders in pedigree dogs. The Veterinary Journal 189(2): 147154CrossRefGoogle ScholarPubMed
Cunningham, E, Dooley, J, Splan, R and Bradley, D 2001 Microsatellite diversity, pedigree relatedness and the contributions of founder lineages to Thoroughbred horses. Animal Genetics 32: 360364CrossRefGoogle ScholarPubMed
Desilva, U and Fitch, J Oklahoma State University Board of Regents 1995 Breeds of Livestock. http://www.ansi.okstate.edu/breeds/horses. (Accessed 13 February 2009)Google Scholar
Farm Animal Welfare Council (FAWC) 2009 Five Freedoms. http://www.fawc.org.uk/freedoms.htm. (Accessed 17 August 2009)Google Scholar
Finno, CJ, Spier, SJ and Valberg, SJ 2009 Equine diseases caused by known genetic mutations. The Veterinary Journal 179: 336347CrossRefGoogle ScholarPubMed
Gough, A and Thomas, A 2010 Breed Predispositions to Disease in Dogs and Cats, Second Edition. John Wiley & Sons Ltd: Chichester, UKGoogle Scholar
Graves, KT 2005 Genetic disease in the horse. Journal of Equine Veterinary Science 25: 255CrossRefGoogle Scholar
Horse Tradition 2007 A guide of the world's top horse breeds: ranking the most popular horse breeds in the world. http://www.horsetradition.com. (Accessed 10 August 2009)Google Scholar
Luescher, UA, McKeown, DB and Dean, H 1998 A cross-sectional study on compulsive behaviour (stable vices) in horses. Equine Veterinary Journal Supplement 27: 1418Google Scholar
MacKay, RJ 2005 Neurologic disorders of neonatal foals. Veterinary Clinics of North America-Equine Practice 21: 387406CrossRefGoogle ScholarPubMed
McGreevy, PD, Cripps, PJ, French, NP, Green, LE and Nicol, CJ 1995 Management factors associated with stereotypic and redirected behaviour in the Thoroughbred horse. Equine Veterinary Journal 27: 8691CrossRefGoogle ScholarPubMed
National Equine Database (NED) 2009 National Equine Database Online. http://www.nedonline.co.uk. (Accessed 14 August 2009)Google Scholar
Naylor, JM, Robinson, JA and Bertone, J 1992 Familial incidence of hyperkalemic periodic paralysis in quarter horses. Journal of the American Veterinary Medical Association 200: 340343Google ScholarPubMed
Online Mendelian Inheritance in Animals (OMIA) 2009 Reprogen. Faculty of Veterinary Science, University of Sydney and Australian National Genomic Information Service (ANGIS), University of Sydney, 2009. Online Mendelian Inheritance in Animals. http://omia.angis.org.au/browse.shtml. (Accessed 23 April 2009)Google Scholar
Summers, JF, Diesel, G, Asher, L, McGreevy, PD and Collins, LM 2010 Inherited defects in pedigree dogs II: non-conformational disorders. The Veterinary Journal 183: 3945CrossRefGoogle Scholar
Swinburne, J 2009 Inherited disease in the horse: mapping complex disease variants is on the horizon. The Veterinary Journal 179: 317318CrossRefGoogle Scholar
Traas, AM, Casal, M, Haskins, M and Henthorn, P 2006 Genetic counseling in the era of molecular diagnostics. Theriogenology 66: 599605CrossRefGoogle ScholarPubMed
Supplementary material: File

Bettley et al. supplementary material
Download undefined(File)
File 540 KB
PDF 540 KB