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Behavioural evaluation of analgesic efficacy for pain mitigation in lame sows

Published online by Cambridge University Press:  01 January 2023

MD Pairis-Garcia ,
AK Johnson ,
KJ Stalder ,
CA Abell ,
LA Karriker ,
JF Coetzee  and
ST Millman
MD Pairis-Garcia
Affiliation:
Department of Animal Science, Iowa State University, Ames, IA 50011, USA
AK Johnson*
Affiliation:
2356F Kildee Hall, Iowa State University, Ames, IA, USA Department of Animal Science, Iowa State University, Ames, IA 50011, USA
KJ Stalder
Affiliation:
Department of Animal Science, Iowa State University, Ames, IA 50011, USA
CA Abell
Affiliation:
Department of Animal Science, Iowa State University, Ames, IA 50011, USA
LA Karriker
Affiliation:
Swine Medicine Education Center, Iowa State University, Ames, IA 50011, USA Veterinary Diagnostic and Production Animal, Iowa State University, Ames, IA 50011, USA
JF Coetzee
Affiliation:
Pharmacology Analytical Support Service, Iowa State University, Ames, IA 50011, USA Veterinary Diagnostic and Production Animal, Iowa State University, Ames, IA 50011, USA
ST Millman
Affiliation:
Veterinary Diagnostic and Production Animal, Iowa State University, Ames, IA 50011, USA Department of Biomedical Science, Iowa State University, Ames, IA 50011, USA
*
* Contact for correspondence and requests for reprints: [email protected]
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Abstract

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Lameness in breeding swine has a large negative economic impact and is a welfare concern. Pain-related behaviour, such as postural changes, may be used to evaluate the presence and severity of pain in animals. The objective of this work was to determine the effects of flunixin meglumine (FM) and meloxicam (M) on postural changes in lame sows. Lameness was induced in 24 mature sows (Sus scrofa) using a chemical synovitis model. Three treatments were compared: FM (2.2 mg kg−1; n = 24, intramuscular [IM]), M (1.0 mg kg−1; n = 24, by mouth [PO]) and sterile saline (equivalent volume to FM; n = 24 [IM]), administered approximately 28 and 52 h after lameness induction. Behavioural data were collected in the home pen during 12-h periods and quantified using 15-min scan sampling on the day prior to (-24 h; Day-1) through +168 h post lameness induction. Frequency of behaviour was analysed by day using generalised linear mixed model methods. The frequency of standing postures significantly decreased and lying postures increased 24-72 h post lameness induction relative to baseline day. All postures returned to baseline frequencies by +168 h. Meloxicam-treated sows demonstrated lower frequencies of lying postures +48 and +72 h after lameness induction compared to saline-treated sows. Flunixin-treated sows did not differ in lying behaviours compared to saline-treated sows. No differences were noted in standing or sitting postures between treatments. The results of this study suggest that meloxicam mitigates pain sensitivity as demonstrated by higher frequency of standing and lower frequency of lying compared to saline-treated sows.

Keywords

animal welfarebehaviourflunixin megluminelamenessmeloxicamswine
Type
Research Article
Information
Animal Welfare , Volume 24 , Issue 1 , February 2015 , pp. 93 - 99
Copyright
© 2015 Universities Federation for Animal Welfare

References

Alsaaod, M, Romer, C, Kleinmanns, J, Hendrikson, K, Rose-Meierhofer, S, Plumer, L and Buscher, W 2012 Electronic detection of lameness in dairy cows through measuring pedomet-ric activity and lying behavior. Applied Animal Behaviour Science 142: 134–141. http://dx.doi.org/10.1016/j.applanim.2012.10.001CrossRefGoogle Scholar
Anil, S, Anil, L and Deen, J 2009 Effect of lameness on sow longevity. Journal American Veterinary Medical Association 235(6):734-738. http://dx.doi.org/10.2460/javma.235.6.734CrossRefGoogle Scholar
Blackie, N, Bleach, E, Amory, J and Scaife, J 2011 Impact of lameness on gait characteristics and lying behaviour of zero grazed dairy cattle in early lactation. Applied Animal Behaviour Science 129:67–73. http://dx.doi.org/10.1016/j.applanim.2010.10.006CrossRefGoogle Scholar
Bonde, M, Rousing, T, Badsberg, JH and Sørensen, JT 2004 Associations between lying-down behaviour problems and body condition, limb disorders and skin lesions of lactating sows housed in farrowing crates in commercial sow herds. Livestock Production Science 87: 179–187. http://dx.doi.org/10.1016/j.livprod-sci.2003.08.005CrossRefGoogle Scholar
Coetzee, JF 2011 A review of pain assessment techniques and pharmacological approaches to pain relief after bovine castration: Practical implications for cattle production within the United States. Applied Animal Behaviour Science 135: 192–213. http://dx.doi.org/10.1016/j.applanim.2011.10.016CrossRefGoogle Scholar
Coetzee, JF, Mosher, RA, Anderson, DE, Robert, B, Kohake, LE, Gehring, R, White, BJ, Kukanich, B and Wang, C 2014 Impact of oral meloxicam administered alone or in combination with gabapentin on experimentally-induced lameness in beef calves. Journal of Animal Science 92: 816–829. http://dx.doi.org/10.2527/jas.2013-6999CrossRefGoogle ScholarPubMed
Danbury, TC, Weeks, CA, Waterman-Pearson, AE, Kestin, SC and Chambers, JC 2000 Self-selection of the analgesic drug carpofen by lame broiler chickens. Veterinary Record 146: 307–311. http://dx.doi.org/10.1136/vr.146.11.307CrossRefGoogle Scholar
Engblom, L, Lundeheim, N, Standberg, E, Schneider, M and Dalin, A 2008 Factors affecting length of productive life in Swedish commercial sows. Journal of Animal Science 86(2): 432-441. http://dx.doi.org/10.2527/jas.2007-0310CrossRefGoogle Scholar
Friton, GM, Philipp, H, Schneider, T and Kleeman, R 2003 Investigation on the clinical efficacy and safety of meloxicam (Metacam®) in the treatment of non-infectious locomotor disorders in pigs. Berliner und Munchener Tierarztliche Wochenschrift 116: 421–426Google ScholarPubMed
Gregoire, J, Bergeron, R, D’Allaire, S, Meunier-Salaun, MC and Devillers, N 2013 Assessment of lameness in sows using gait, footprints, postural behaviour and foot lesion analysis. Animal 7(7): 1163–1173. http://dx.doi.org/10.1017/S1751731113000098CrossRefGoogle ScholarPubMed
Haley, D 2010 Pain relief in pigs. http://www.centraliaswinere-search.ca/proceedings/2010/csru2010proceedings.pdfGoogle Scholar
Hansson, M, Lundeheim, N, Nyman, G and Johansson, G 2011 Effect of local anaesthesia and/or analgesia on pain respons-es induced by piglet castration. Acta Veterinaria Scandinavica 53: 34. http://dx.doi.org/10.1186/1751-0147-53-34CrossRefGoogle ScholarPubMed
Heinonen, M, Oravainen, J, Orro, T, Seppa-Lassila, L, Ala-Kurikka, E, Virolainen, J, Tast, A and Peltoniemi, OAT 2006 Lameness and fertility of sows and gilts in randomly selected loose-housed herds in Finland. Veterinary Record 159: 383–387. http://dx.doi.org/10.1136/vr.159.12.383CrossRefGoogle ScholarPubMed
Heinrich, A, Duffield, TF, Lissemore, KD and Millman, ST 2010 The effect of meloxicam on behavior and pain sensitivity of dairy calves following cautery dehorning with a local anaesthetic. Journal of Dairy Science 93: 2450–2457. http://dx.doi.org/10.3168/jds.2009-2813CrossRefGoogle Scholar
Higginson Cutler, JH, Shearer, JK, Kelton, DF, Cramer, G, Gorden, P and Millman, ST An observational study of the effects of therapeutic hoof blocks on the locomotion, behaviour, and production of healthy dairy cattle. Journal of Applied Animal Welfare Science, in pressGoogle Scholar
Ito, K, von Keyserlingk, MAG, LeBlanc, SJ and Weary, DM 2010 Lying behavior as an indicator of lameness in dairy cows. Journal of Dairy Science 93: 3553–3560. http://dx.doi.org/10.3168/jds.2009-2951CrossRefGoogle ScholarPubMed
Karriker, LA, Abell, CE, Pairis-Garcia, MD, Holt, WA, Sun, S, Coetzee, JF, Johnson, AK, Hoff, SJ and Stalder, KJ 2013 Validation of a lameness model in sows using physiological and mechanical measurements. Journal of Animal Science 91: 130–136. http://dx.doi.org/10.2527/jas.2011-4994CrossRefGoogle ScholarPubMed
Keita, A, Pagot, E, Prunier, A and Guidarini, C 2010 Pre-emptive meloxicam for post-operative analgesia in piglets undergoing surgical castration. Veterinary Anaesthesia and Analgesia 37: 367–374. http://dx.doi.org/10.1111/j.1467-2995.2010.00546.xCrossRefGoogle Scholar
KilBride, AL, Gillman, CE and Green, LE 2009 A cross-sectional study of prevalence of lameness in finishing pigs, gilts and pregnant sows and associations with limb lesions and floor types on commercial farms in England. Animal Welfare 18: 215–224Google Scholar
Kluviers-Poodt, M, Zonderland, JJ, Verbraak, J, Lambooij, E and Hellebrekers, LJ 2013 Pain behaviour after castration of piglets; effect of pain relief with lidocaine and/or meloxicam. Animal 7:1158–1162. http://dx.doi.org/10.1017/S1751731113000086CrossRefGoogle Scholar
Knauer, M, Stalder, KJ, Baas, T, Johnson, C and Karriker, LA 2012 Physical condition of cull sows associated with on-farm pro-duction records. Open Journal of Veterinary Medicine 2: 137–150. http://dx.doi.org/10.4236/ojvm.2012.23023CrossRefGoogle Scholar
Kotschwar, JL, Coetzee, JF, Anderson, DE, Gehring, R, KuKanich, B and Appley, MD 2009 Analgesic efficacy of sodi-um salicylate in an amphotericin B-induced bovine synotivis-arthritis model. Journal Dairy Science 92: 3731–3743CrossRefGoogle Scholar
Maddison, JE, Page, SW and Dyke, TM 2008 Clinical pharma-cokinetics. In: Maddison, JE, Page, S and Church, D (eds) Small Animal Clinical Pharmacology pp 27–40. WB Saunders: Philadelphia, USA. http://dx.doi.org/10.1016/B978-070202858-8.50004-XCrossRefGoogle Scholar
Main, D, Clegg, J, Spatz, A and Green, L 2000 Repeatability of a lameness scoring system for finishing pigs. Veterinary Record 147(20): 574–576. http://dx.doi.org/10.1136/vr.147.20.574CrossRefGoogle ScholarPubMed
Martin, P and Bateson, P 2007 Recording methods. In: Martin, P and Bateson, P (eds) Measuring Behaviour: An Introductory Guide pp 48–60. Cambridge University Press: Cambridge, UK. http://dx.doi.org/10.1017/CBO9780511810893.006CrossRefGoogle Scholar
Mohling, CM, Johnson, AK, Coetzee, JF, Karriker, LA, Stalder, KJ, Abell, CE, Tyler, HE and Millman, ST 2014a Evaluation of mechanical and thermal nociception as objective tools to measure painful and nonpainful lameness phases in multi-parous sows. Journal of Animal Science 92: 3073–3081. http://dx.doi.org/10.2527/jas.2013-7521CrossRefGoogle Scholar
Mohling, CM, Johnson, AK, Coetzee, JF, Karriker, LA, Abell, CE, Millman, ST and Stalder, KJ 2014b Kinematics as objective tools to evaluate lameness phases in multiparous sows. Livestock Science 165: 120–128. http://dx.doi.org/10.1016/j.livsci.2014.04.031CrossRefGoogle Scholar
NHF (National Hog Farmer) 2013 State of the Industry. http://nationalhogfarmer.com/site-files/national hogfarmer.com/files/uploads/2013/06/NHF-St-of-Industry-13.pdfGoogle Scholar
NPB (National Pork Board) 2013 PQA plus® Site Assessment Guide. Pork Checkoff: Des Moines, IA, USAGoogle Scholar
NRC (National Research Council) 2012 Subcommittee on Swine Nutrition; Committee on Animal Nutrition. Nutrient Requirements of Swine. The National Academic Press: Washington DC, USAGoogle Scholar
O’Callaghan, KA, Cripps, PJ, Downham, DY and Murray, RD 2003 Subjective and objective assessment of pain and discom-fort due to lameness in dairy cattle. Animal Welfare 12: 605–610Google Scholar
Pairis-Garcia, MD, Johnson, AK, Stalder, KJ, Karriker, LA, Coetzee, JF and Millman, ST 2014a Measuring the efficacy of flunixin meglumine and meloxicam for lame sows using nociceptive threshold tests. Animal Welfare 23(2): 219–229. http://dx.doi.org/10.7120/09627286.23.2.219CrossRefGoogle Scholar
Pairis-Garcia, MD, Johnson, AK, KuKanich, B, Wulf, L, Millman, ST, Stalder, KJ, Karriker, LA, and Coetzee, JF 2014b Pharmacokinetics of meloxicam in mature swine after intravenous and oral administration. Journal Veterinary Pharmacology and Therapeutics. http://dx.doi.org/10.1111/jvp.12170CrossRefGoogle Scholar
Pairis-Garcia, MD, Karriker, LA, Johnson, AK, KuKanich, B, Wulf, L, Sander, S, Millman, ST, Stalder, KJ and Coetzee, JF 2013 Pharmacokinetics of flunixin meglumine in mature swine after intravenous, intramuscular and oral adminis-tration. BMC Veterinary Research 9: 165CrossRefGoogle Scholar
Pauly, C, White, BJ, Coetzee, JF, Robert, B, Baldridge, S and Renter, DG 2012 Evaluation of analgesic protocol effect on calf behavior after concurrent castration and dehorning. The Journal of Applied Research in Veterinary Medicine 10(1): 54–61Google Scholar
Pluym, LM, Van Nuffel, A, Van Weyenberg, S and Maes, D 2013 Prevalence of lameness and claw lesions during different stages in the reproductive cycle of sows and the impact of repro-duction results. Animal 7: 1174–1181. http://dx.doi.org/10.1017/S 1751731113000232CrossRefGoogle Scholar
Reiner, G, Schollasch, F, Hillen, S, Willems, H, Piechotta, M and Failing, K 2012 Effects of meloxicam and flunixin on pain, stress and discomfort in male piglets during and after surgical castration. Berliner und Münchener tierärztliche Wochenschrift 125: 305–314Google ScholarPubMed
Ringgenberg, N, Bergeron, R and Devillers, N 2010 Validation of accelerometers to automatically record sow postures and stepping behaviour. Applied Animal Behaviour Science 128: 37–44. http://dx.doi.org/10.1016/j.applanim.2010.09.018CrossRefGoogle Scholar
Schenk, E, Marchant-Forde, J and Lay, D 2010 Sow lameness and longevity. USDA-ARS-MWA Livestock Behavior Research Unit. Purdue University: West Lafayette, USAGoogle Scholar
Schulz, KL, Anderson, DE, Coetzee, JF, White, BJ and Miesner, MD 2011 Effect of flunixin meglumine on the amelioration of lameness in an amphotericin B induced transient synovitis arthritis model in dairy steers. American Journal of Veterinary Research 72:1431–1438. http://dx.doi.org/10.2460/ajvr.72.11.1431CrossRefGoogle Scholar
Shearer, JK, Stock, ML, Van Amstel, SR and Coetzee, JF 2013 Assessment and management of pain associated with lameness in cattle. Veterinary Clinics North America: Food Animal Practice 29(1): 135–156. http://dx.doi.org/10.1016/j.cvfa.2012.11.012Google ScholarPubMed
Smith, B 1988 Lameness in pigs associated with foot and limb disor-ders. In Practic e 10: 113-117. http://dx.doi.org/10.1136/inpract.10.3.113CrossRefGoogle Scholar
Stalder, K, Lacy, R, Cross, T and Conaster, G 2003 Financial impact of average parity of culled females in a breed-to-wean swine operation using replacement gilt net present value analysis. Journal of Swine Health and Production 11: 69–74Google Scholar
Stubsjøen, SM, Flø, AS, Moe, RO, Janczak, AM, Skerve, E, Valle, PS and Zanella, AJ 2009 Exploring non-invasive methods to assess pain in sheep. Physiology and Behavior 98: 640–648. http://dx.doi.org/10.1016/j.physbeh.2009.09.019CrossRefGoogle ScholarPubMed
Underwood, WJ 2002 Pain and distress in agricultural animals. Journal American Veterinary Association 221: 208–211. http://dx.doi.org/10.2460/javma.2002.221.208CrossRefGoogle ScholarPubMed
Weeks, CA, Danbury, TD, Davies, HC, Hunt, P and Kestin, SC 2000 The behaviour of broiler chickens and its modification by lameness. Applied Animal Behaviour Science 67: 111–125. http://dx.doi.org/10.1016/S0168-1591(99)00102-1CrossRefGoogle ScholarPubMed
Welfare Quality® 2011 Welfare Quality® Assessment Protocol for Cattle. Welfare Quality® Consortium: Lelystad, The NetherlandsGoogle Scholar
Wells, G 1984 Locomotor disorders of the pig. In Practice 6: 43–53. http://dx.doi.org/10.1136/inpract.6.2.43CrossRefGoogle ScholarPubMed