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Reproductive and lactational responses and serum growth hormone and insulin in fine-wool ewes treated with ovine growth hormone

Published online by Cambridge University Press:  02 September 2010

D. W. Holcombe ,
D. M. Hallford  and
W. C. Hoefler
D. W. Holcombe
Affiliation:
Department of Animal and Range Sciences, New Mexico State University, Las Cruces, New Mexico 88003–0009, USA
D. M. Hallford
Affiliation:
Department of Animal and Range Sciences, New Mexico State University, Las Cruces, New Mexico 88003–0009, USA
W. C. Hoefler
Affiliation:
Department of Animal and Range Sciences, New Mexico State University, Las Cruces, New Mexico 88003–0009, USA
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Abstract

Eighteen mature (3 to 6 years) Debouillet × Rambouillet ewes (mean weight 79·2 (s.e. 21) kg) producing and nursing single offspring were randomly allotted to one of three groups to examine the influence of ovine growth hormone (oGH) on reproductive, hormonal and lactational responses of springlambing ewes. Each ewe received a daily subcutaneous injection of either 0, 5 or 10 mg oGH from day 11 through to day 20 post partum (day 0 = parturition). Treatment groups were subdivided into two pens (three ewes per pen) and food intake was monitored from day 1 through to day 20 post partum. On days 11 and 20 post partum, jugular blood samples were collected before and hourly for 8 h after treatment. Blood samples were also collected daily from day 10 through to day 21 post partum and on alternate days through to day 40 post partum. Milk production (oxytocin-induced hand milking) and fat and protein concentrations were determined 21 days post partum. Food intake did not differ before or during the treatment period (P > 0·05). Likewise, ewe and lamb weights were similar among treatment groups through to day 60 post partum (P > 0·05). Serum insulin did not differ before or after treatment on day 11 (P > 0·05); however, on day 20 before treatment, serum insulin was significantly higher in ewes receiving 5 (2·3 (s.e. 0·3) μg/I) and 10 (2·4 (s.e. 0·3) μg/1) mg oGH than in controls (1·2 (s.e. 0·3) μg/1) (P < 0·05). After treatment, no differences were detected in serum insulin among treatments on day 20 post partum (P > 0·05). Serum growth hormone (GH) was similar among groups before treatment on day 11 post partum; but by 8 h after treatment, serum GH was significantly elevated in ewes receiving 10 mg oGH (32·4 (s.e. 1·9) μg/1) compared with ewes receiving 5 (13·9 (s.e. 1·9) μg/1) or 0 (4·5 (s.e. 1·9) μg/1) mg oGH (P < 0·01). By 20 days after lambing, serum GH differed significantly among groups both before and after administration of exogenous oGH (P < 0·01). Ewes receiving 5 or 10 mg oGH produced 2·3 (s.e. 0·2) kg milk per day compared with 1·9 (s.e. 0·2) kg/day for controls (P < 0·10). Milk fat and protein concentrations did not differ significantly among treatments (P > 0·05), but total fat yield was higher in ewes receiving either dose of oGH (206 (s.e. 20) g/day) compared with control ewes (141 (s.e. 20) g/day) (P < 005). Serum progesterone remained less than 0·5 μg/1 in ewes through to day 40 post partum. A linear decrease was observed in interval from parturition to first observed oestrus as dosage of oGH increased (116, 108 and 102 (s.e. 6) days for ewes receiving 0, 5 and 10 mg oGH, respectively; P = 0·10). Administration of exogenous oGH to lactating. anoestrous ewes between days 11 and 20 post partum enhances milk production and may influence the interval to oestrus.

Type
Research Article
Information
Animal Production , Volume 46 , Issue 2 , April 1988 , pp. 195 - 202
Copyright
Copyright © British Society of Animal Science 1988

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References

Association of Official Analytical Chemists. 1984. Official Methods of Analysis. 14th ed. Association of Official Analytical Chemists, Washington, DC.Google Scholar
Bauman, D. E., Eppard, P. J., Degeeter, M. J. and Lanza, G. M. 1985. Response of high-producing dairy cows to long-term treatment with pituitary somatotropin and recombinant somatotropin. Journal of Dairy Science 68: 1352–1362.CrossRefGoogle ScholarPubMed
Bauman, D. E. and McCutcheon, S. N. 1986. The effects of growth hormone and prolactin on metabolism. Control of Digestion and Metabolism in Ruminants (ed. Milligan, L. P., Grovum, W. L. and Dobson, A.), pp. 436–455. Englewood Cliffs, New Jersey.Google Scholar
Bines, J. A. and Hart, I. C. 1978. Hormonal regulation of the partition of energy between milk and body tissue in adult cattle. Proceedings of the Nutrition Society 37: 281–287.CrossRefGoogle ScholarPubMed
Bines, J. A., Hart, I. C. and Morant, S. V. 1980. Endocrine control of energy metabolism of the cow: the effect on milk yield and levels of some blood constituents of injecting growth hormone and growth hormone fragments. British Journal of Nutrition 43: 179–188.CrossRefGoogle ScholarPubMed
Call, J. W., Foote, W. C., Eckre, C. D. and Hulet, C. V. 1976. Postpartum uterine and ovarian changes, and estrous behavior from lactation effects in normal and hormone treated ewes. Theriogenology 6: 495–501.CrossRefGoogle ScholarPubMed
Christenson, R. K. 1976. Effect of short-term progestogen treatment on induction of estrus and lambing in anestrous ewes. Journal of Animal Science 43: 795–801.CrossRefGoogle ScholarPubMed
Eppard, P. J., Bauman, D. E. and McCutcheon, S. N. 1985. Effect of dose of bovine growth hormone on lactation of dairy cows. Journal of Dairy Science 68: 1109–1115.CrossRefGoogle ScholarPubMed
Fronk, T. J., Peel, C. J., Bauman, D. E. and Gorewit, R. C. 1983. Comparison of different patterns of exogenous growth hormone administration on milk production in Holstein cows. Journal of Animal Science 57: 699–705.CrossRefGoogle ScholarPubMed
Gill, J. L. and Hafs, H. D. 1971. Analysis of repeated measurements of animals. Journal of Animal Science 33: 331–336.CrossRefGoogle ScholarPubMed
Gorden, L. 1977. Application of synchronization of estrus and ovulation in sheep.Symposium on Management of Reproduction in Sheep and Goat. Madison, Wi, p. 15.Google Scholar
Hallford, D. M., Hudgens, R. E., Morrical, D. G., Schoenemann, H. M., Kiesling, H. E. and Smith, G. S. 1982. Influence of short-term consumption of sewage solids on productivity of fall-lambing ewes and performance of their offspring. Journal of Animal Science 54: 922–932.CrossRefGoogle Scholar
HART, I. C., Bines, J. A., James, S. and Morant, S. V. 1985. The effect of injecting or infusing low doses of bovine growth hormone on milk yield, milk composition and the quantity of hormone in the milk serum of cows. Animal Production 40: 243–250.Google Scholar
Hart, I. C., Chadwick, P. M., James, S. and Simmonds, A. P. 1985. Effect of intravenous bovine growth hormone or human pancreatic growth hormone-releasing factor on milk production and plasma hormones and metabolites in sheep. Journal of Endocrinology 105: 189–196.CrossRefGoogle ScholarPubMed
Hoefler, W. C. and Hallford, D. M. 1987. Influence of suckling status and type of birth on serum hormone profiles and return to estrus in early-postpartum, spring-lambing ewes. Theriogenology 27: 887–895.CrossRefGoogle Scholar
Hulet, C. V. and Foote, W. C. 1967. Physiological factors affecting frequency and rate of lambing. Journal of Animal Science 26: 553–562.CrossRefGoogle ScholarPubMed
Jordan, R. M. and Shaffhausen, D. D. 1954. Effect of somatotropin on milk yield of ewes. Journal of Animal Science 13: 706–710.CrossRefGoogle Scholar
Kronfeld, D. S. 1982. Major metabolic determinants of milk volume, mammary efficiency, and spontaneous ketosis in dairy cows. Journal of Dairy Science 65: 2204–2212.CrossRefGoogle ScholarPubMed
Legan, S. J. and Karsch, F. J. 1979. Neuroendocrine regulation of the estrous cycle and seasonal breeding in the ewe. Biology of Reproduction 20: 74–85.CrossRefGoogle ScholarPubMed
Loerch, S. C., McClure, K. E. and Parker, C. F. 1985. Effects of number of lambs suckled and supplemental protein source on lactating ewe performance. Journal of Animal Science 60: 6–13.CrossRefGoogle ScholarPubMed
McDowell, G. H. 1983. Hormonal control of glucose homeostasis in ruminants. Proceedings of the Nutrition Society 42: 149–165.CrossRefGoogle ScholarPubMed
Mboe, A. Z., Head, H. H., Bachman, K. C. and Wilcox, C. J. 1986. Effect of growth hormone on milk yield, feed intake and some physiological functions during environmental stress. Journal of Dairy Science, Suppl. 1, p. 119 (Abstr.).Google Scholar
Peel, C. J., Fronk, T. J., Bauman, D. E. and Gorewit, R. C. 1982. Lactational response to exogenous growth hormone and abomasal infusion of a glucose-sodium caseinate mixture in high yielding dairy cows. Journal of Nutrition 112: 1770–1777.CrossRefGoogle ScholarPubMed
Peel, C. J., Fronk, T. J., Bauman, D. E. and Gorewit, R. C. 1983. Effect of exogenous growth hormone in early and late lactation on lactational performance of dairy cows. Journal of Dairy Science 66: 776–782.CrossRefGoogle ScholarPubMed
Sanson, D. W. and Hallford, D. M. 1984. Growth response, carcass characteristics and serum glucose and insulin in lambs fed tolazamide. Nutrition Reports International 29: 461–471.Google Scholar
Scott, G. E. 1977. The Sheepman's Production Handbook. Sheep Industry Development Program, Denver, Co.Google Scholar
Sefidbakht, N. and Farid, A. 1977. Effect of early weaning and hormone treatments on induction of estrus, conception and lambing of fall-lambing Karakul ewes. Journal of Animal Science 45: 311–319.CrossRefGoogle ScholarPubMed
Snedecor, G. W. and Cochran, W. G. 1967. Statistical Methods. 6th ed. Iowa State University Press, Ames, Ia.Google Scholar
Wallace, A. L. and Bassett, J. M. 1966. Effect of sheep growth hormone on plasma insulin concentration in sheep. Metabolism 15: 95–97.CrossRefGoogle ScholarPubMed
Wheatley, I. S., Wallace, A. L. and Bassett, J. M. 1966. Metabolic effects of ovine growth hormone in sheep. Journal of Endocrinology 35: 341–353.CrossRefGoogle ScholarPubMed