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Rates of oxalic acid degradation in the rumen of sheep and goats in response to different levels of oxalic acid administration

Published online by Cambridge University Press:  02 September 2010

A. J. Duncan ,
P. Frutos  and
S. A. Young
A. J. Duncan
Affiliation:
Macaulay Land Use Research Institute, Craigiebuckler, Aberdeen AB15 8QH
P. Frutos
Affiliation:
Macaulay Land Use Research Institute, Craigiebuckler, Aberdeen AB15 8QH
S. A. Young
Affiliation:
Macaulay Land Use Research Institute, Craigiebuckler, Aberdeen AB15 8QH
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Abstract

Oxalic acid is found in high concentrations in some plants consumed by ruminants and may cause renal toxicity. To determine whether exposure to oxalic acid affects the capacity of the rumen of sheep and goats to degrade the compound, 20 animals (10 sheep and 10 goats) were dosed with free oxalic acid by gelatin capsule twice daily for 3 weeks at one of five levels (0·0, 0·3, 0·6, 0·9 and 1·2 mmol/kg live weight (M) per day). Rumen samples were collected by stomach tube in the week prior to the start of dosing and in each week of the 3-week experiment. Oxalic acid degradation capacity was measured by adding uC-labelled oxalic acid to rumen fluid in vitro and capturing evolved 14CO2. Rates of degradation increased with increasing level of administration (2·30, 4·71, 6·74, 9·83 and 13·90 mmol of oxalic acid degraded per I rumen fluid per day for doses 0·0, 0·3, 0·6, 0·9 and 1·2 mmol/kg M per day, respectively; P < 0·001). Rates of degradation increased during the dosing period (P < 0·001) with the largest increases occurring in the 1st week of dosing. Goats showed a greater response than sheep, with a higher mean oxalic acid degradation capacity (9·04 v. 5·95 mmol of oxalic acid degraded per I rumen fluid, P < 0·05). Oxalic acid administration did not influence plasma calcium concentration or cause renal function impairment as measured by plasma creatinine concentrations. The experiment demonstrated adaptation in the rumen to potential toxins in the host diet and suggests that the rumen micro-organisms of goats may have been more adapted to degrading oxalic acid than sheep.

Keywords

goatsoxalic acidrumen degradationsheep
Type
Research Article
Information
Animal Science , Volume 65 , Issue 3 , December 1997 , pp. 451 - 455
Copyright
Copyright © British Society of Animal Science 1997

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References

Allison, M. J., Cook, H. M. and Dawson, K. A. 1981. Selection of oxalate degrading rumen bacteria in continuous cultures. Journal of Animal Science 53: 810–816.CrossRefGoogle Scholar
Allison, M. J., Dawson, K. A., Mayberry, W. R. and Foss, J. G. 1985. Oxalobacterformigenes gen. nov., sp. nov.: oxalate-degrading anaerobes that inhabit the gastrointestinal tract. Archives of Microbiology 141:1–7.CrossRefGoogle Scholar
Allison, M. J., Littledike, E. T. and James, L. F. 1977. Changes in ruminal oxalate degradation rates associated with adaptation to oxalate ingestion. journal of Animal Science 45:1173–1179.CrossRefGoogle ScholarPubMed
Carlson, J. R. and Breeze, R. G. 1984. Ruminal metabolism of plant toxins with emphasis on indolic compounds. journal of Animal Science 58:1040–1049.CrossRefGoogle ScholarPubMed
Domingue, B. M. F., Dellow, D. W., Wilson, P. R. and Barry, T. N. 1991a. Comparative digestion in deer, goats, and sheep. New Zealand Journal of Agricultural Research 34:45–53.CrossRefGoogle Scholar
Domingue, B. M. F., Dellow, D. W., Wilson, P. R. and Barry, T. N. 1991b. Nitrogen-metabolism, rumen fermentation, and water-absorption in red deer, goats, and sheep. New Zealand journal of Agricultural Research 34: 391–400.CrossRefGoogle Scholar
Duncan, A. J. and Milne, J. A. 1992. Rumen microbial degradation of allyl cyanide as a possible explanation for the tolerance of sheep to brassica-derived glucosinolates. journal of the Science of Food and Agriculture 58:15–19.CrossRefGoogle Scholar
Howe, J. C., Barry, T. N. and Popay, A. I. 1988. Voluntary intake and digestion of gorse (Ulex europaeus) by goats and sheep, journal of Agricultural Science, Cambridge 111: 107–114.CrossRefGoogle Scholar
James, L. F. 1972. Oxalate toxicosis. Clinical Toxicology 5: 231–243.CrossRefGoogle ScholarPubMed
Kronberg, S. L. and Walker, J. W. 1993. Ruminal metabolism of leafy spurge in sheep and goats – a potential explanation for differential foraging on spurge by sheep, goats, and cattle. Journal of Chemical Ecology 19:2007–2017.CrossRefGoogle ScholarPubMed
Kyriazakis, I., Papachristou, T. G., Duncan, A. J. and Gordon, I. 1997. Mild conditioned food aversions developed by sheep towards flavours associated with plant secondary compounds. Journal of Chemical Ecology 23: 727–746.CrossRefGoogle Scholar
Lanigan, G. W. and Smith, L. W. 1970. Metabolism of pyrrolizidine alkaloids in the ovine rumen. I. Formation of 7-alpha-hydroxyl-alphamethyl-8-alpha pyrrolizidine from heliotrine and basiocarpine. Australian journal ofAgricultural Research 21:493–500.CrossRefGoogle Scholar
Lawes Agricultural Trust. 1989. Genstat 5 committee of the statistics department, Rothamsted Experimental Station, Oxford University Press.Google Scholar
Libert, B. and Franceschi, R. 1987. Oxalate in crop plants. Journal of Agricultural and Food Chemistry 35: 926–938.CrossRefGoogle Scholar
McCabe, S. M. and Barry, T. N. 1988. Nutritive-value of willow (Salix sp) for sheep, goats and deer. Journal of Agricultural Science, Cambridge 111: 1–9.CrossRefGoogle Scholar
McDougall, E. I. 1948. Studies on ruminant saliva. I. The composition and output of sheep's saliva. Biochemical Journal 43: 99–109.CrossRefGoogle ScholarPubMed
Majak, W. and Cheng, K.-J. 1987. Hydrolysis of the cyanogenic glucosides amygdalin, prunasin and linamarin by ruminal micro-organisms. Canadian journal of Animal Science 67:1133–1137.CrossRefGoogle Scholar
Narjisse, H., Elhonsali, M. A. and Olsen, J. D. 1995. Effects of oak (Quercus ilex) tannins on digestion and nitrogen-balance in sheep and goats. Small Ruminant Research 18: 201–206.CrossRefGoogle Scholar
Pemberton, R. W. 1986. The distribution of halogeton in North America. Journal of Range Management 39: 281–282.CrossRefGoogle Scholar
Roberts, D. J. and Martindale, J. F. 1990. Fodder beet: a review of research findings in relation to animal production. In Milk and meat from forage crops (ed. Pollot, G. E.), occasional symposium, British Grassland Society, no. 24, pp. 137–152. British Grassland Society, Maidenhead.Google Scholar
Voth, L. M. 1981. Determination of calcium and magnesium in blood serum by automated flame microsampling. Varian Atomic Absorption AA-15:1–4.Google Scholar
Watts, P. S. 1959. Effects of oxalic acid ingestion by sheep. II. Large doses to sheep on different diets. Journal of Agricultural Science, Cambridge 52:250–255.CrossRefGoogle Scholar