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Oral administration of spermine advances intestinal maturation in sucking piglets

Published online by Cambridge University Press:  09 March 2007

Z. B. Cheng ,
D. F. Li ,
J. J. Xing ,
X. Y. Guo  and
Z. J. Li
Z. B. Cheng
Affiliation:
National Key Laboratory of Animal Nutrition, China Agricultural University, Beijing 100094, People's Republic of China Department of Animal Science and Technology, Yunnan Agricultural University, Kunming City, Yunnan Province 650201, People's Republic of China
D. F. Li*
Affiliation:
National Key Laboratory of Animal Nutrition, China Agricultural University, Beijing 100094, People's Republic of China
J. J. Xing
Affiliation:
National Key Laboratory of Animal Nutrition, China Agricultural University, Beijing 100094, People's Republic of China
X. Y. Guo
Affiliation:
National Key Laboratory of Animal Nutrition, China Agricultural University, Beijing 100094, People's Republic of China
Z. J. Li
Affiliation:
National Key Laboratory of Animal Nutrition, China Agricultural University, Beijing 100094, People's Republic of China
*
†Corresponding author: E-mail: [email protected]
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Abstract

The objective of this study was to investigate the effect of orally administered spermine at various doses on intestinal maturation in sucking piglets. Thirty-six 11-day-old sucking piglets were assigned randomly to one of six treatments to receive via a stomach tube 0, 0·1, 0·2, 0·3, 0·4, or 0·5 mmol spermine per kg live weight (LW) per day for 3 days. At day 14 of age, duodenum, jejunum and ileum were obtained for biochemical and morphological analysis. Increasing the dose of orally administered spermine increased intestinal weight (linear effect, P<0·01), mucosal weight (linear effect, P<0·05), and mucosal protein, DNA and RNA contents of the duodenum (linear effect, P≤0·01) and jejunum (linear effect, P<0·01). Elevating spermine doses also enhanced (linear effect, P≤0·02) the specific activities of maltase and sucrase but decreased (linear effect, P<0·01) lactase specific activity in the jejunum and duodenum. Furthermore, augmenting oral doses of spermine increased crypt depth and villus width but reduced villus height in the jejunum (linear effect, P<0·05) and duodenum (linear effect, P<0·01). For most measurements, the effects were observed at the oral spermine doses of 0·3 to 0·5 mmol/kg LW per day. Collectively, the results show that oral administration of optimal doses of spermine to 11-day-old sucking piglets induces precocious intestinal maturation and promotes intestinal growth.

Keywords

disaccharidasesintestinespigletsspermine
Type
Research Article
Information
Animal Science , Volume 82 , Issue 5 , October 2006 , pp. 621 - 626
Copyright
Copyright © British Society of Animal Science 2006

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