Hostname: page-component-78c5997874-t5tsf Total loading time: 0 Render date: 2024-11-20T01:25:53.820Z Has data issue: false hasContentIssue false
  • English
  • Français

Effect of bovine somatotropin administration during the last trimester of gestation on maternal growth, and foetal and placental development in primigravid ewes

Published online by Cambridge University Press:  02 September 2010

K. Stelwagen ,
D. G. Grieve ,
J. S. Walton ,
J. L. Ball  and
B. W. McBride
K. Stelwagen
Affiliation:
Department of Animal and Poultry Science, University of Guelph, Guelph, Ontario, N1G 2W1, Canada
D. G. Grieve
Affiliation:
Department of Animal and Poultry Science, University of Guelph, Guelph, Ontario, N1G 2W1, Canada
J. S. Walton
Affiliation:
Department of Animal and Poultry Science, University of Guelph, Guelph, Ontario, N1G 2W1, Canada
J. L. Ball
Affiliation:
Department of Animal and Poultry Science, University of Guelph, Guelph, Ontario, N1G 2W1, Canada
B. W. McBride
Affiliation:
Department of Animal and Poultry Science, University of Guelph, Guelph, Ontario, N1G 2W1, Canada
Get access

Abstract

Twenty-five primigravid ewes were used in a preliminary study to investigate the effect of bovine somatotropin (bST) between 97 and 124 days of gestation, on maternaland foetal growthand development. Five ewes (reference group) were slaughteredat 96 days of gestation, and the remaining ewes were injected daily with saline (control group: no = 10) or 0·1 mg/kgbody weight of bST (bST group: no. = 10). Following bST treatment, five control- and five bST groupewes were slaughtered (slaughter group). The remaining ewes (production group) were allowed to lamb, after which the lambs were slaughtered within 2 h of birth. Bovine somatotropin reducedthe proportion of maternal body fat, but had no major impacton wool growth, maternal gain and gross skeletal measurements, and foetal growth and development. Maternal bST treatment tended to affect the number of placentomes. It should, however, be emphasized that these results are based on small numbers of animals and that further research in this area is required.

Keywords

body compositionewesfoetal growthplacentasomatotropin
Type
Research Article
Information
Animal Production , Volume 58 , Issue 1 , February 1994 , pp. 87 - 94
Copyright
Copyright © British Society of Animal Science 1994

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Association of Official Analytical Chemists. 1990. Official methods of analysis of the Association of Official Analytical Chemists. 13th ed. AOAC Inc, Arlington, VA.Google Scholar
Bell, A. W., McBride, B. W., Slepetis, R., Early, R. J. and Currie, W. B. 1989. Chronic heat stress and prenatal development in sheep. 1. Conceptus growth and maternal plasma hormones and metabolites. journal of Animal Science 67: 3289–3299.CrossRefGoogle ScholarPubMed
Blanchard, M. M., Goodyer, C. G., Charrier, J., Kann, G., Garcia-Villar, R., Bousquet-Melou, A., Toutain, P. L. and Barenton, B. 1991. GRF treatment of late pregnantewes alters maternal and fetal somatotropic axis activity. American journal of Physiology 260: E575–E580.Google Scholar
Boyd, R. D. and Bauman, D. E. 1989. Mechanisms of action forsomatotropinin growth. In Current concepts of animal growth regulation (ed. Campion, D. R., Hausman, G. J. and Martin, R. J.), Plenum, New York.Google Scholar
Chilliard, Y. 1989. Long-term effects of recombinant bovine somatotropin (rbST) on dairy cow performances: a review. In Use of somatotropin in livestock production (ed. Sejrsen, K., Vestergaard, M. and Neimann-Sorensen, A.), pp. 61–87. Elsevier Applied Science, London.Google Scholar
Clemmons, D. R. and Underwood, L. E. 1991. Nutritional regulation of IGF-1 and IGF binding proteins. Annual Reviews of Nutrition 11: 393–412.CrossRefGoogle ScholarPubMed
D'Ercole, A. J. and Underwood, L. E. 1981. Growth factors in fetal growth and development. In Fetal endocrinology (ed. Novy, M. J. and Resko, J. A.), pp. 155–182. Academic Press, New York.CrossRefGoogle Scholar
Enright, W.J. 1989. Effects of administration of somatotropin on growth, feed efficiency and carcass composition of ruminants: a review. In Use of somatotropin in livestock production (ed. Sejrsen, K., Vestergaard, M. and Neimann-Sorensen, A.), pp. 132–156. Elsevier Applied Science,London.Google Scholar
Eppard, P. J., Bauman, D. E., Curtis, C. R., Erb, H. N., Lanza, G. M. and DeGeeter, M. J. 1987. Effect of 188-day treatment with somatotropin on health and reproductive performance of lactating dairy cows. Journal of Dairy Science 70: 582–591.CrossRefGoogle ScholarPubMed
Gargosky, S. E., Owens, I. A., Walton, P. E., Owens, P. C., Wallace, J. C. and Ballard, F. J. 1991. Administration of insulin-like growth factor-1, but not growth hormone, increases maternal weight gain in late pregnancy without affecting fetal or placental growth. journal of Endocrinology 130: 395–400.CrossRefGoogle ScholarPubMed
Gluckman, P. D. 1986. The role of pituitary hormones, growth factors and insulin in the regulation of fetal growth. Oxford Reviews of Reproduction and Physiology 7: 1–60.Google Scholar
Jacob, R., Barrett, E., Plewe, G., Fagin, K. D. and Sherwin, R. S. 1989. Acute effects of insulin-like growth factor-1 on glucose and amino acid metabolism in the awake fasted rat — comparison with insulin, journal of Clinical Investigation 83: 1717–1723.CrossRefGoogle ScholarPubMed
Johnsson, I. D., Hart, I. C. and Butler-Hogg, B. W. 1985. The effects of exogenous bovine growth hormone and bromocriptine on growth, body development, fleece weight and plasma concentrations of growth hormone, insulin and prolactin in female lambs. Animal Production 41: 207–217.Google Scholar
Lunt, D. K., Smith, G. C., McKeith, F. K., Savell, J. W., Riewe, M. E., Horn, F. P. and Coleman, S. W. 1985. Techniques for predicting beef carcass composition. journalof Animal Science 60: 1201–1207.CrossRefGoogle Scholar
Metcalfe, J., Stock, M. K. and Barron, D. H. 1988. Maternal physiology during gestation. In Thephysiology of reproduction (ed. Knobil, E. and Neil, J.), pp. 2145–2176. Raven Press, New York.Google Scholar
National Research Council. 1985. Nutrient requirements of sheep. 6th rev.ed. National Academy of Science, Washington, DC.Google Scholar
Ontario Ministry of Agriculture and Food. 1985. Body condition scoring of sheep. Fact sheet no. 85–062. Ontario Ministry of Agriculture and Food, Canada.Google Scholar
Pell, J. M. and Bates, P. C. 1987. Collagen and non-collagen protein turnover in skeletal muscle of growth-hormone treated lambs. Journal of Endocrinology 115: R1–R4.CrossRefGoogle ScholarPubMed
Salmon, J. W. D. and Duvall, M. R. 1970. In vitro stimulation of leucine incorporation into muscle and cartilage protein by a serum fraction with sulfation factor activity: differentiation of effects from those of growth hormone and insulin. Endocrinology 87: 1168–1180.CrossRefGoogle ScholarPubMed
Statistical Analysis Systems Institute. 1985. SAS user's guide: statistics. SAS Institute, Inc., Cary, NC.Google Scholar
Schoknecht, P. A., Nobrega, S. N., Petterson, J. A., Ehrhardt, R. A., Slepetis, R. and Bell, A. W. 1991. Relations between maternal and fetal plasma concentrations of placental lactogen and placental and fetal weights in wellfed ewes. Journal of Animal Science 69: 1059–1063.CrossRefGoogle ScholarPubMed
Stelwagen, K., Grieve, D. G., McBride, B. M. and Rehman, J. D. 1992. Growth and subsequent lactation in primigravid Holstein heifers after prepartum bovine somatotropin treatment. Journal of Dairy Science 75: 463–471.CrossRefGoogle ScholarPubMed
Stelwagen, K., Grieve, D. G., Walton, J. S., Ball, J. L. and McBride, B. M. 1993. Effect ofbovine somatotropin administration during late gestation in primigravid ewes on mammogenesis, subsequent milk yield, and plasma insulin-like growth factor-1 concentrations. Journal of Dairy Science 76: 992–1001.CrossRefGoogle Scholar
Van Wyk, J. J., Underwood, L. E., D'Ercole, A. J., Clemmons, D. R., Pledger, W. J., Wharton, W. R. and Leof, E. B. 1981. In Role of somatomedin in cellular proliferation (ed. Ritzen, M.), pp. 223–239. Raven Press, New York.Google Scholar